EFFECT OF ULTRA‐VIOLET IRRADIATION OF PHENYLEPHRINE SOLUTIONS

Solutions of phenylephrine in distilled water were irradiated with ultra‐violet light for 3 hr. The irradiated solutions tested on perfused guinea‐pig lungs had a bronchodilator potency greater than that of the original non‐irradiated phenylephrine solution. The bioassay and photofluorometric determinations (Shore and Olin method) suggested that adrenaline had been formed from phenylephrine in the irradiated solution.