Disorders of saccades

Saccades are rapid eye movements that assist vision by pointing the fovea of the retina, which contains the highest density of photoreceptors, at features of interest in the visual environment. A great deal is now known about the properties and neurobiology of saccades in both health and disease states. They have consequently become a valuable diagnostic and research tool. In this review, we describe the common saccadic disorders and their causes. We also highlight recent insights into the pathophysiologic mechanisms underlying these disorders and discuss how these insights have helped increase our understanding of the saccadic system as a whole.

[1]  R. John Leigh,et al.  Evidence for independent feedback control of horizontal and vertical saccades from Niemann-Pick type C disease , 1997, Vision Research.

[2]  Matthew J. Thurtell Effect of eye position on the three-dimensional kinematics of saccadic and vestibular-evoked eye movements , 2005 .

[3]  Yanning H. Han,et al.  Abnormalities of optokinetic nystagmus in progressive supranuclear palsy , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[4]  W. Heide,et al.  Different types of intra‐saccadic slowing in congenital (RAPSN‐mutation) and acquired myasthenic syndromes , 2006, European journal of neurology.

[5]  R. Leigh,et al.  Dysfunction of pontine omnipause neurons causes impaired fixation: macrosaccadic oscillations with a unilateral pontine lesion. , 1996, Neuro-ophthalmology.

[6]  Agnes M F Wong,et al.  Listing's law: clinical significance and implications for neural control. , 2004, Survey of ophthalmology.

[7]  D. Robinson Oculomotor unit behavior in the monkey. , 1970, Journal of neurophysiology.

[8]  R. Rafal Oculomotor Functions of the Parietal Lobe: Effects of Chronic Lesions in Humans , 2006, Cortex.

[9]  C. A. Marzi,et al.  Abnormally speeded saccades to ipsilesional targets in patients with spatial neglect , 2007, Neuropsychologia.

[10]  B. Dan,et al.  Opsoclonus-myoclonus associated with celiac disease. , 2006, Pediatric neurology.

[11]  A. Fuchs,et al.  The role of the cerebellum in voluntary eye movements. , 2001, Annual review of neuroscience.

[12]  L. Dell’Osso,et al.  “Staircase” Saccadic Intrusions plus Transient Yoking and Neural Integrator Failure Associated with Cerebellar Hypoplasia: A Model Simulation , 2006, Seminars in ophthalmology.

[13]  R. Leigh,et al.  Ocular myasthenia revisited: Insights from pseudo-internuclear ophthalmoplegia , 2007, Journal of Neurology.

[14]  R. Leigh,et al.  The neurology of eye movements , 1984 .

[15]  D. Zee,et al.  Ocular motor indicators of executive dysfunction in fragile X and Turner syndromes , 2007, Brain and Cognition.

[16]  C. Karatekin Improving antisaccade performance in adolescents with attention-deficit/hyperactivity disorder (ADHD) , 2006, Experimental Brain Research.

[17]  F. Pierelli,et al.  Ataxia with oculomotor apraxia type 2 , 2006, Neurology.

[18]  Richard V Abadi,et al.  Characteristics of saccadic intrusions , 2004, Vision Research.

[19]  M. Alemdar,et al.  Unilateral midbrain infarction causing upward and downward gaze palsy. , 2006, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.

[20]  P. Fitzgerald,et al.  Ocular motor differences between melancholic and non-melancholic depression. , 2006, Journal of affective disorders.

[21]  F. Mauguière,et al.  Opsoclonus–myoclonus as a manifestation of Lyme disease , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[22]  W M Grove,et al.  Saccadic disinhibition in patients with acute and remitted schizophrenia and their first-degree biological relatives. , 2001, The American journal of psychiatry.

[23]  A. Horn The reticular formation. , 2006, Progress in brain research.

[24]  Matcheri S Keshavan,et al.  Longitudinal studies of antisaccades in antipsychotic-naive first-episode schizophrenia , 2006, Psychological Medicine.

[25]  J. Gnadt,et al.  Irrepressible saccades from a tectal lesion in a Rhesus monkey , 2006, Vision Research.

[26]  D. Pélisson,et al.  Saccadic lateropulsion in Wallenberg syndrome: a window to access cerebellar control of saccades? , 2006, Experimental Brain Research.

[27]  J. Sharpe,et al.  Saccade dynamics in peripheral vs central sixth nerve palsies , 2006, Neurology.

[28]  Pascal Wurtz,et al.  One-Hertz transcranial magnetic stimulation over the frontal eye field induces lasting inhibition of saccade triggering , 2006, Neuroreport.

[29]  Yanning H. Han,et al.  Neuro-ophthalmology of late-onset Tay–Sachs disease (LOTS) , 2004, Neurology.

[30]  T Raphan,et al.  Modeling control of eye orientation in three dimensions. I. Role of muscle pulleys in determining saccadic trajectory. , 1998, Journal of neurophysiology.

[31]  B. Volpe,et al.  Saccadic Palsy after Cardiac Surgery , 2002, Annals of the New York Academy of Sciences.

[32]  Kevin A. Kerber,et al.  A longitudinal study of oculomotor function in normal older people , 2006, Neurobiology of Aging.

[33]  Joseph L Demer,et al.  Current concepts of mechanical and neural factors in ocular motility , 2006, Current opinion in neurology.

[34]  P. Kramer,et al.  Ocular contrapulsion in multiple sclerosis: clinical features and pathophysiological mechanisms , 2001, Journal of neurology, neurosurgery, and psychiatry.

[35]  R. Wurtz,et al.  The Neurobiology of Saccadic Eye Movements , 1989 .

[36]  Tony Ro,et al.  Modulation of antisaccades by transcranial magnetic stimulation of the human frontal eye field. , 2006, Cerebral cortex.

[37]  M. Pranzatelli,et al.  Rituximab (anti-CD20) Adjunctive Therapy for Opsoclonus-Myoclonus Syndrome , 2006, Journal of pediatric hematology/oncology.

[38]  M Vidailhet,et al.  Mixing pro- and antisaccades in patients with parkinsonian syndromes. , 2006, Brain : a journal of neurology.

[39]  B. Bembi,et al.  Saccade testing in the diagnosis and treatment of type 3 Gaucher disease , 2005, Neurology.

[40]  D. Kömpf,et al.  Saccade initiation in ocular motor apraxia , 2006, Journal of Neurology.

[41]  Parashkev Nachev,et al.  Role of the human supplementary eye field in the control of saccadic eye movements , 2007, Neuropsychologia.

[42]  Ken-ichiro Miura,et al.  Membrane channel properties of premotor excitatory burst neurons may underlie saccade slowing after lesions of omnipause neurons , 2006, Journal of Computational Neuroscience.

[43]  C. Gordon,et al.  A rare saccade velocity profile in Stiff-Person Syndrome with cerebellar degeneration , 2006, Brain Research.

[44]  B. Gaymard,et al.  Unidirectional ocular flutter , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[45]  L. Optican,et al.  What clinical disorders tell us about the neural control of saccadic eye movements , 2006 .

[46]  Albert F Fuchs,et al.  Effect of pharmacological inactivation of nucleus reticularis tegmenti pontis on saccadic eye movements in the monkey. , 2006, Journal of neurophysiology.

[47]  E. Eggenberger,et al.  Asaccadia and Ataxia after Repair of Ascending Aortic Aneurysm , 2007, Seminars in ophthalmology.

[48]  S. Koh,et al.  Ocular flutter induced only by optokinetic stimulation , 2006, Journal of Clinical Neuroscience.

[49]  A. Wong An update on opsoclonus , 2007, Current opinion in neurology.

[50]  C. Kennard,et al.  Identification of an oculomotor biomarker of preclinical Huntington disease , 2006, Neurology.

[51]  R. Clement,et al.  Saccadic instabilities in albinism without nystagmus , 2006, Experimental Brain Research.

[52]  O. Onodera Spinocerebellar ataxia with ocular motor apraxia and DNA repair , 2006, Neuropathology : official journal of the Japanese Society of Neuropathology.

[53]  D. Newman-Toker,et al.  Anti-Ma2-associated encephalitis with normal FDG-PET: a case of pseudo-Whipple's disease , 2006, Nature Clinical Practice Neurology.

[54]  T. Vilis,et al.  Geometric relations of eye position and velocity vectors during saccades , 1990, Vision Research.