Effect of sodium hyaluronate (0.1%) on break-up time (NIBUT) in patients with dry eyes.

We evaluated the effect of 0.1% sodium hyaluronate (unpreserved) in 10 patients with dry eyes. The precorneal tear film break-up time was assessed by the non-invasive technique, and the severity of symptoms was recorded before and after treatment on a 0 to +3 scale. It was found that the tear film stability was significantly increased (p less than 0.05) in eyes treated with sodium hyaluronate. The symptoms of grittiness and burning were also significantly alleviated in the treated eyes.

[1]  Deluise Vp,et al.  The use of topical Healon tears in the management of refractory dry-eye syndrome. , 1984, Annals of Ophthalmology.

[2]  J. D. Cameron,et al.  Cellulose acetate impressions of the ocular surface. Dry eye states. , 1983, Archives of ophthalmology.

[3]  F. Polack,et al.  The Treatment of Dry Eyes with Na Hyaluronate (Healon®) , 1982 .

[4]  R. Farris,et al.  Osmolarity of tear microvolumes in keratoconjunctivitis sicca. , 1978, Archives of ophthalmology.

[5]  M A Lemp,et al.  Tear physiology and dry eyes. , 1977, Survey of ophthalmology.

[6]  K. Kurihashi.  FINE COTTON THREAD METHOD OF LACRIMATION , 1976, The Lancet.

[7]  J. Forrester,et al.  Management of the dry eye in Sjogren's syndrome. , 1974, The British journal of ophthalmology.

[8]  M. Lemp,et al.  The Preocular Tear Film and Dry Eye Syndromes , 1973 .

[9]  M. Lemp,et al.  RECENT ADVANCES IN OCULAR SURFACE CHEMISTRY* , 1970, American journal of optometry and archives of American Academy of Optometry.

[10]  M. Norn,et al.  DESICCATION OF THE PRECORNEAL FILM , 1969, Acta ophthalmologica.

[11]  O. P. Bijsterveld,et al.  Diagnostic Tests in the Sicca Syndrome , 1969 .

[12]  L S Mengher,et al.  A non-invasive instrument for clinical assessment of the pre-corneal tear film stability. , 1985, Current eye research.

[13]  L S Mengher,et al.  Effect of fluorescein instillation on the pre-corneal tear film stability. , 1985, Current eye research.

[14]  F. Holly,et al.  Kinetics of lacrimal secretion in normal human subjects , 1984 .

[15]  Fraunfelder Ft.  Extraocular fluid dynamics: how best to apply topical ocular medication. , 1976 .

[16]  O. P. van Bijsterveld.  Diagnostic tests in the Sicca syndrome. , 1969, Archives of ophthalmology.