Skin barrier function alteration induced by noise and solvent exposure among aircraft maintenance workers

Purpose This study was aimed to investigate whether the single exposure of noise, solvent, and co-exposure of noise and solvents alter skin barrier functions. Methods Forty-four male airplane maintenance workers were recruited in this study in the middle of Taiwan. All subjects underwent skin barrier function tests, including basal transepidermal water loss (TEWL), basal water content (WC), skin barrier integrity, and skin barrier recovery. Results We found that organic solvent exposure affected the stratum corneum superficially and raised the basal TEWL (6.1 g/m2/h (SD 0.8 g/m2/h) vs. 4.6 g/m2/h (SD 0.6 g/m2/h) in the solvent exposure group and control group, respectively (p < 0.01)). In addition, noise exposure showed the increasing pattern of barrier integrity (78.8 (SD 9.2) vs. 48.9 (SD 13.8) in noise exposure group and control group, respectively (p < 0.01)) and decreasing pattern of 6h recovery (20.4% (SD 5.6%) vs. 43.6% (SD 11.5%) in noise exposure group and control group, respectively (p < 0.01)). Conclusion These results indicated that noise and solvent exposure might affect skin health or cause skin disorders among workers. Further study about the relationship between noise, solvent, and skin barrier function should point to potential mechanisms caused by stratum corneum exposures.

[1]  P. Elias.  Primary role of barrier dysfunction in the pathogenesis of atopic dermatitis , 2018, Experimental dermatology.

[2]  S. Zare,et al.  The Effect of Occupational Noise Exposure on Serum Cortisol Concentration of Night-shift Industrial Workers: A Field Study , 2018, Safety and health at work.

[3]  R. Brook,et al.  Environmental stressors and cardio-metabolic disease: part I–epidemiologic evidence supporting a role for noise and air pollution and effects of mitigation strategies , 2016, European heart journal.

[4]  Aleksandr Stefaniak,et al.  International guidelines for the in vivo assessment of skin properties in non‐clinical settings: Part 2. transepidermal water loss and skin hydration , 2013, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[5]  P. Nassiri,et al.  Industrial noise exposure and salivary cortisol in blue collar industrial workers. , 2012, Noise & health.

[6]  Y. Chan,et al.  Skin barrier structure and function and their relationship to pruritus in end-stage renal disease. , 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[7]  T. Robles.  Stress, Social Support, and Delayed Skin Barrier Recovery , 2007, Psychosomatic medicine.

[8]  P. Elias,et al.  Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity. , 2005, The Journal of investigative dermatology.

[9]  T. Shih,et al.  Effect of Occupational Exposure to Rayon Manufacturing Chemicals on Skin Barrier to Evaporative Water Loss , 2004, Journal of occupational health.

[10]  P. Elias,et al.  Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities. , 2003, The Journal of investigative dermatology.

[11]  H. Ishida,et al.  Study of active substances involved in skin dysfunction induced by crowding stress. I. Effect of crowding and isolation on some physiological variables, skin function and skin blood perfusion in hairless mice. , 2003, Biological & pharmaceutical bulletin.

[12]  J. Tsai,et al.  Effect of barrier disruption by acetone treatment on the permeability of compounds with various lipophilicities: implications for the permeability of compromised skin. , 2001, Journal of pharmaceutical sciences.

[13]  F. Dhabhar,et al.  Stress-induced changes in skin barrier function in healthy women. , 2001, The Journal of investigative dermatology.

[14]  P. Wertz,et al.  Effect of Selective Lipid Extraction from Different Body Regions on Epidermal Barrier Function , 2001, Pharmaceutical Research.

[15]  H. Ising,et al.  Acute and chronic endocrine effects of noise: Review of the research conducted at the Institute for Water, Soil and Air Hygiene. , 2000, Noise & health.

[16]  M. Denda,et al.  Immobilization‐induced and crowded environment‐induced stress delay barrier recovery in murine skin , 1998, The British journal of dermatology.

[17]  R. Potts.  Skin Barrier: Principles of Percutaneous Absorption , 1997 .

[18]  M. Fartasch.  Ultrastructure of the epidermal barrier after irritation , 1997, Microscopy research and technique.

[19]  H. Maibach,et al.  Effect of organic solvents on in vitro human skin water barrier function. , 1993, The Journal of investigative dermatology.

[20]  P. Elias,et al.  Lamellar body secretory response to barrier disruption. , 1992, The Journal of investigative dermatology.

[21]  M. Steinhoff,et al.  Psychoneuroimmunology of psychological stress and atopic dermatitis: pathophysiologic and therapeutic updates. , 2012, Acta dermato-venereologica.

[22]  H Ising,et al.  Health effects caused by noise: evidence in the literature from the past 25 years. , 2004, Noise & health.

[23]  W. Babisch,et al.  Stress hormones in the research on cardiovascular effects of noise. , 2003, Noise & health.

[24]  M. Chren,et al.  Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. , 2001, Archives of dermatology.