Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia

[1]  M. Fullwood,et al.  Super Enhancer-Mediated Upregulation of HJURP Promotes Growth and Survival of t(4;14)-Positive Multiple Myeloma , 2021, Cancer Research.

[2]  Lin Chen,et al.  Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers , 2021, Nature Communications.

[3]  Weilong Hong,et al.  Super-enhancer-driven lncRNA-DAW promotes liver cancer cell proliferation through activation of Wnt/β-catenin pathway , 2021, Molecular Therapy. Nucleic Acids.

[4]  Haitao Wang,et al.  Key sunitinib‐related biomarkers for renal cell carcinoma , 2021, Cancer medicine.

[5]  Cheng Huang,et al.  Super-enhancer-associated TMEM44-AS1 aggravated glioma progression by forming a positive feedback loop with Myc , 2021, Journal of experimental & clinical cancer research : CR.

[6]  Cun-Yu Wang,et al.  Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma , 2021, Nature Communications.

[7]  S. Kesari,et al.  Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling , 2021, BMC Neurology.

[8]  F. Zanini,et al.  Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells. , 2021, Blood.

[9]  Catherine Lai,et al.  Advances in therapeutic options for newly diagnosed, high-risk AML patients , 2021, Therapeutic advances in hematology.

[10]  W. Wang,et al.  Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling , 2021, Nature Communications.

[11]  C. Récher Clinical Implications of Inflammation in Acute Myeloid Leukemia , 2021, Frontiers in Oncology.

[12]  Blandine Roux,et al.  Descriptive and Functional Genomics in Acute Myeloid Leukemia (AML): Paving the Road for a Cure , 2021, Cancers.

[13]  K. Ozato,et al.  DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner , 2020, Frontiers in Molecular Biosciences.

[14]  B. Göttgens,et al.  Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells , 2020, bioRxiv.

[15]  Liewei Wang,et al.  Aberrant activation of super enhancer and choline metabolism drive antiandrogen therapy resistance in prostate cancer , 2020, Oncogene.

[16]  Iris Z. Uras,et al.  CDK6 Inhibition: A Novel Approach in AML Management , 2020, International journal of molecular sciences.

[17]  D. Hao,et al.  Overexpression of FES might inhibit cell proliferation, migration, and invasion of osteosarcoma cells , 2020, Cancer Cell International.

[18]  I. Touw,et al.  RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia , 2020, Molecules and cells.

[19]  D. Beck,et al.  Shared roles for Scl and Lyl1 in murine platelet production and function. , 2019, Blood.

[20]  B. Ko,et al.  Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in patients with acute myeloid leukemia and myelodysplastic syndrome , 2019, BMC Cancer.

[21]  Trevor Siggers,et al.  NextPBM: a platform to study cell-specific transcription factor binding and cooperativity , 2019, Nucleic acids research.

[22]  C. Wells,et al.  Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias , 2018, Nature Communications.

[23]  Yizhou Huang,et al.  A novel role for Lyl1 in primitive erythropoiesis , 2018, Development.

[24]  H. Chung,et al.  LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data , 2018, BMC Cancer.

[25]  Hamid Bolouri,et al.  The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions , 2017, Nature Medicine.

[26]  S. Armstrong,et al.  ENL links histone acetylation to oncogenic gene expression in AML , 2017, Nature.

[27]  K. Yanagihara,et al.  Title Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT 3 B , 2017 .

[28]  Asim Khwaja,et al.  Acute myeloid leukaemia , 2016, Nature Reviews Disease Primers.

[29]  H. Kantarjian Acute myeloid leukemia—Major progress over four decades and glimpses into the future , 2016, American journal of hematology.

[30]  Jean-Philippe Vert,et al.  HiC-Pro: an optimized and flexible pipeline for Hi-C data processing , 2015, Genome Biology.

[31]  S. Armstrong,et al.  JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors , 2015, Genes & development.

[32]  H. Kantarjian,et al.  Toward Individualized Therapy in Acute Myeloid Leukemia: A Contemporary Review. , 2015, JAMA oncology.

[33]  Bandana Sharma,et al.  CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer , 2014, Cell.

[34]  Sridhar Ramaswamy,et al.  Targeting transcription regulation in cancer with a covalent CDK7 inhibitor , 2014, Nature.

[35]  D. Sasaki,et al.  Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B , 2014, Leukemia.

[36]  Charles Y. Lin,et al.  Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. , 2013, Cancer cell.

[37]  R. Young,et al.  Super-Enhancers in the Control of Cell Identity and Disease , 2013, Cell.

[38]  David A. Orlando,et al.  Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes , 2013, Cell.

[39]  David A. Orlando,et al.  Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers , 2013, Cell.

[40]  C. Stiller,et al.  Incidence, survival and prevalence of myeloid malignancies in Europe. , 2012, European journal of cancer.

[41]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[42]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[43]  Helga Thorvaldsdóttir,et al.  Integrative Genomics Viewer , 2011, Nature Biotechnology.

[44]  H. Harada,et al.  Molecular pathways mediating MDS/AML with focus on AML1/RUNX1 point mutations , 2009, Journal of cellular physiology.

[45]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[46]  J. Dick,et al.  Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia , 2005, Leukemia.

[47]  H. Kantarjian,et al.  Acute myeloid leukemia , 2018, Methods in Molecular Biology.