Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload.

[1]  S. Houser,et al.  Pleiotropic effects of neutrophils on myocyte apoptosis and left ventricular remodeling during early volume overload. , 2009, Journal of molecular and cellular cardiology.

[2]  M. Crackower,et al.  Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. , 2008, Cardiovascular research.

[3]  L. Dell’Italia,et al.  Sympathetic Activation Causes Focal Adhesion Signaling Alteration in Early Compensated Volume Overload Attributable to Isolated Mitral Regurgitation in the Dog , 2008, Circulation research.

[4]  D. Aronoff,et al.  Activation of Phosphatase and Tensin Homolog on Chromosome 10 Mediates the Inhibition of FcγR Phagocytosis by Prostaglandin E2 in Alveolar Macrophages1 , 2007, The Journal of Immunology.

[5]  M. Rojas,et al.  Myocyte-Restricted Focal Adhesion Kinase Deletion Attenuates Pressure Overload–Induced Hypertrophy , 2006, Circulation research.

[6]  L. Dell’Italia,et al.  Role of Protein-tyrosine Phosphatase SHP2 in Focal Adhesion Kinase Down-regulation during Neutrophil Cathepsin G-induced Cardiomyocytes Anoikis* , 2006, Journal of Biological Chemistry.

[7]  P. Insel,et al.  Focal Adhesions in (Myo)fibroblasts Scaffold Adenylyl Cyclase with Phosphorylated Caveolin* , 2006, Journal of Biological Chemistry.

[8]  J. Guan,et al.  Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. , 2005, The Journal of clinical investigation.

[9]  Sábata S Constancio,et al.  Focal Adhesion Kinase Is Activated and Mediates the Early Hypertrophic Response to Stretch in Cardiac Myocytes , 2003, Circulation research.

[10]  L. Dell’Italia,et al.  &bgr;1-Adrenergic Receptor Blockade Attenuates Angiotensin II–Mediated Catecholamine Release Into the Cardiac Interstitium in Mitral Regurgitation , 2003, Circulation.

[11]  Zhonglin Xie,et al.  β1 integrins expression in adult rat ventricular myocytes and its role in the regulation of β‐adrenergic receptor‐stimulated apoptosis , 2003 .

[12]  B. Kobilka,et al.  Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. , 2003, The Journal of clinical investigation.

[13]  D. Sawyer,et al.  &bgr;-Adrenergic Receptor–Stimulated Apoptosis in Cardiac Myocytes Is Mediated by Reactive Oxygen Species/c-Jun NH2-Terminal Kinase–Dependent Activation of the Mitochondrial Pathway , 2003, Circulation research.

[14]  Mark A Sussman,et al.  Activation of pyk2/Related Focal Adhesion Tyrosine Kinase and Focal Adhesion Kinase in Cardiac Remodeling* , 2002, The Journal of Biological Chemistry.

[15]  C. Kahn,et al.  Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways , 2002, Cell.

[16]  A. Samarel,et al.  PYK2 expression and phosphorylation increases in pressure overload-induced left ventricular hypertrophy. , 2002, American journal of physiology. Heart and circulatory physiology.

[17]  A. Samarel,et al.  GFP-FRNK Disrupts Focal Adhesions and Induces Anoikis in Neonatal Rat Ventricular Myocytes , 2002, Circulation research.

[18]  S. Cherry,et al.  Cardiac Myocyte-Specific Excision of the &bgr;1 Integrin Gene Results in Myocardial Fibrosis and Cardiac Failure , 2002, Circulation research.

[19]  J. Robbins,et al.  The Tumor Suppressor Gene PTEN Can Regulate Cardiac Hypertrophy and Survival* , 2001, The Journal of Biological Chemistry.

[20]  S. Houser,et al.  Patients With End-Stage Congestive Heart Failure Treated With &bgr;-Adrenergic Receptor Antagonists Have Improved Ventricular Myocyte Calcium Regulatory Protein Abundance , 2001, Circulation.

[21]  M. Schaller.  Biochemical signals and biological responses elicited by the focal adhesion kinase. , 2001, Biochimica et biophysica acta.

[22]  R. Ross,et al.  Integrins and the myocardium. , 2001, Genetic engineering.

[23]  J. Port,et al.  Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure. , 2001, Journal of molecular and cellular cardiology.

[24]  S. Goldstein,et al.  Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure. , 2000, Journal of the American College of Cardiology.

[25]  M. A. Saad,et al.  Early Activation of the Multicomponent Signaling Complex Associated With Focal Adhesion Kinase Induced by Pressure Overload in the Rat Heart , 2000, Circulation research.

[26]  W. Colucci,et al.  p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis , 2000, The Journal of Biological Chemistry.

[27]  J. Taylor,et al.  A Role for Focal Adhesion Kinase in Phenylephrine-induced Hypertrophy of Rat Ventricular Cardiomyocytes* , 2000, The Journal of Biological Chemistry.

[28]  G. Dorn,et al.  Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. , 2000, Circulation.

[29]  Catherine Communal,et al.  Opposing Effects of β1- and β2-Adrenergic Receptors on Cardiac Myocyte Apoptosis Role of a Pertussis Toxin–Sensitive G Protein , 1999 .

[30]  S. Steinberg.  The molecular basis for distinct beta-adrenergic receptor subtype actions in cardiomyocytes. , 1999, Circulation research.

[31]  M. Lohse,et al.  Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Kenneth M. Yamada,et al.  Tumor Suppressor PTEN Inhibits Integrin- and Growth Factor–mediated Mitogen-activated Protein (MAP) Kinase Signaling Pathways , 1998, The Journal of cell biology.

[33]  D. Pimentel,et al.  Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. , 1998, Circulation.

[34]  S. Vatner,et al.  Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac Gsα Overexpression , 1996 .

[35]  S. Aizawa,et al.  Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice , 1995, Nature.

[36]  B. Carabello,et al.  Effects of chronic beta-adrenergic blockade on the left ventricular and cardiocyte abnormalities of chronic canine mitral regurgitation. , 1994, The Journal of clinical investigation.

[37]  D. Sawyer,et al.  Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein. , 1999, Circulation.