Sequences and factors: a guide to MHC class-II transcription.

The expression of the class-II antigens of the major histocompatibility complex is tissue-specific, developmentally regulated in cells of the B lineage, and inducible by cytokine. Some of the molecular mechanisms that account for this regulation have recently been elucidated. DNA sequences upstream of human and mouse class-II genes that are critical for the transcription of these genes have been identified through transfection studies and transgenic analysis. Furthermore, a number of transcription factors that bind to important promoter motifs have recently been isolated. Examination of the class-II promoter in vivo both in the normal state and in patients with bare lymphocyte syndrome has further increased our understanding of class-II regulation.

[1]  M. Fellous,et al.  Human chromosome 16 encodes a factor involved in induction of class II major histocompatibility antigens by interferon gamma. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[2]  S. Urieli-Shoval,et al.  Defective HLA DRA X box binding in the class II transactive transcription factor mutant 6.1.6 and in cell lines from class II immunodeficient patients. , 1991, Journal of immunology.

[3]  P. A. Peterson,et al.  A novel class II MHC molecule with unusual tissue distribution , 1991, Nature.

[4]  L. Glimcher,et al.  Upstream elements of the MHC class II E beta gene active in B cells. , 1991, Journal of immunology.

[5]  C. Benoist,et al.  The E alpha promoter: a linker-scanning analysis. , 1991, Journal of immunology.

[6]  V. Kouskoff,et al.  NF-X, a transcription factor implicated in MHC class II gene regulation. , 1991, Journal of immunology.

[7]  J. Ting,et al.  Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function , 1991, Molecular and cellular biology.

[8]  J. Ting,et al.  Sequences homologous to class II MHC W, X, and Y elements mediate constitutive and IFN-gamma-induced expression of human class II-associated invariant chain gene. , 1991, Journal of immunology.

[9]  W. Reith,et al.  Regulatory factor-X binding to mutant HLA-DRA promoter sequences. , 1991, Nucleic acids research.

[10]  N. Zeleznik-Le,et al.  Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Santa Jeremy Ono,et al.  An isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DP , 1991, The Journal of experimental medicine.

[12]  J. Ting,et al.  The W element is a positive regulator of HLA-DRA transcription in various DR+ cell types. , 1991, Journal of immunology.

[13]  R. Maki,et al.  IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway. , 1991, Journal of immunology.

[14]  M. Kern,et al.  The same CCAAT box-binding factor binds to the promoter of two coordinately regulated major histocompatibility complex class II genes , 1991, Molecular and cellular biology.

[15]  T. Mosmann,et al.  Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells , 1990, The Journal of experimental medicine.

[16]  B. Peterlin,et al.  NF-X2 that binds to the DRA X2-box is activator protein 1. Expression cloning of c-Jun. , 1990, Journal of immunology.

[17]  G. Tsokos,et al.  Effects of cholera toxin on human B cells. Cholera toxin induces B cell surface DR expression while it inhibits anti-mu antibody-induced cell proliferation. , 1990, Journal of immunology.

[18]  J. Ting,et al.  X-box-binding proteins positively and negatively regulate transcription of the HLA-DRA gene through interaction with discrete upstream W and V elements. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[19]  C. Benoist,et al.  Co‐evolution from yeast to mouse: cDNA cloning of the two NF‐Y (CP‐1/CBF) subunits. , 1990, The EMBO journal.

[20]  W. Reith,et al.  MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. , 1990, Genes & development.

[21]  C. Hume,et al.  Functional analysis of cis-linked regulatory sequences in the HLA DRA promoter by transcription in vitro. , 1990, Tissue antigens.

[22]  A. Siddiqui,et al.  Trans-activation of HLA-DR gene by hepatitis B virus X gene product. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[23]  L. Zhu,et al.  Transcriptional control of the invariant chain gene involves promoter and enhancer elements common to and distinct from major histocompatibility complex class II genes , 1990, Molecular and cellular biology.

[24]  N. Koch,et al.  Tumor necrosis factor alpha regulates expression of the major histocompatibility complex class II-associated invariant chain by binding of an NF-kappa B-like factor to a promoter element , 1990, Molecular and cellular biology.

[25]  J. Papamatheakis,et al.  Induction of class II MHC antigen expression on the murine placenta by 5-azacytidine correlates with fetal abortion. , 1990, Cellular immunology.

[26]  J. Strominger,et al.  Regulation of the class II-associated invariant chain gene in normal and mutant B lymphocytes. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[27]  H. Rahmsdorf,et al.  The IFN-gamma response of the murine invariant chain gene is mediated by a complex enhancer that includes several MHC class II consensus elements. , 1990, Journal of immunology.

[28]  M. Klemsz,et al.  The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene , 1990, Cell.

[29]  Y. Freund,et al.  cis-acting sequences required for class II gene regulation by interferon gamma and tumor necrosis factor alpha in a murine macrophage cell line , 1990, The Journal of experimental medicine.

[30]  I. Verma,et al.  mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element , 1990, Molecular and cellular biology.

[31]  N. Zeleznik-Le,et al.  A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter. , 1990, Science.

[32]  R. Hunter,et al.  Induction of macrophage Ia expression in vivo by a synthetic block copolymer, L81. , 1990, Journal of immunology.

[33]  W. Reith,et al.  Two DNA-binding proteins discriminate between the promoters of different members of the major histocompatibility complex class II multigene family , 1990, Molecular and cellular biology.

[34]  M. Nakanishi,et al.  Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors , 1990, Molecular and cellular biology.

[35]  L. Glimcher,et al.  Interferon gamma regulates binding of two nuclear protein complexes in a macrophage cell line. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[36]  B. Wold,et al.  In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. , 1990, Science.

[37]  C. Hume,et al.  Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors. , 1989, Human immunology.

[38]  R. Maki,et al.  Evidence for multiple major histocompatibility class II X-box binding proteins , 1989, Molecular and cellular biology.

[39]  G. Firestein,et al.  Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis , 1989, The Journal of experimental medicine.

[40]  A. Heguy,et al.  The octamer motif is a B-lymphocyte-specific regulatory element of the HLA-DR alpha gene promoter. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[41]  L. Glimcher,et al.  A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B. , 1989, Molecular and cellular biology.

[42]  C. Benoist,et al.  Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant. , 1989, Science.

[43]  W. Reith,et al.  Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[44]  M. Klemsz,et al.  Interferon‐γ activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I‐Aβ, tumor necrosis factor and complement component C3 in mouse macrophages , 1989 .

[45]  B. Gansbacher,et al.  HLA class II mRNA accumulation by activated human T cells following growth in conditioned medium. , 1989, Clinical and experimental immunology.

[46]  J. Guardiola,et al.  Transcriptional and post-transcriptional regulation of human MHC class II genes require the synthesis of short-lived proteins. , 1989, Journal of immunology.

[47]  J. Woodward,et al.  Induction of class II MHC antigen expression in macrophages by Mycoplasma species. , 1989, Journal of immunology.

[48]  D. Schendel,et al.  Differential surface expression of class II isotypes on activated CD4 and CD8 cells correlates with levels of locus-specific mRNA. , 1989, Journal of immunology.

[49]  C. Hume,et al.  Bare lymphocyte syndrome: altered HLA class II expression in B cell lines derived from two patients. , 1989, Human immunology.

[50]  P. Dellabona,et al.  Transcriptional control of MHC class II gene expression during differentiation from B cells to plasma cells. , 1989, Journal of immunology.

[51]  R. Flavell,et al.  Selective expression of class II E alpha d gene in transgenic mice. , 1989, Journal of immunology.

[52]  W. Reith,et al.  Induction of HLA class II genes by IFN-gamma is transcriptional and requires a trans-acting protein. , 1989, Journal of immunology.

[53]  Daniel Lucey,et al.  Mature human eosinophils have the capacity to express HLA-DR. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[54]  L. Glimcher,et al.  Differences in DNA sequence specificity among MHC class II X box binding proteins. , 1989, Journal of immunology.

[55]  C. Benoist,et al.  Anatomy of a new B-cell-specific enhancer , 1989, Molecular and cellular biology.

[56]  L. Glimcher,et al.  A DNA binding protein regulated by IL-4 and by differentiation in B cells. , 1988, Science.

[57]  W. Schaffner,et al.  A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells , 1988, Nature.

[58]  A. Reske-Kunz,et al.  Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function. , 1988, Journal of immunology.

[59]  W. Herr,et al.  The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. , 1988, Genes & development.

[60]  J. Ting,et al.  Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[61]  J. M. Boss,et al.  Conserved upstream sequences of human class II major histocompatibility genes enhance expression of class II genes in wild-type but not mutant B-cell lines. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[62]  L. Glimcher,et al.  Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element. , 1988, Science.

[63]  D. K. Didier,et al.  Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[64]  J. Strominger,et al.  B-cell-specific enhancer activity of conserved upstream elements of the class II major histocompatibility complex DQB gene. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[65]  D. Pious,et al.  Transcription of HLA class II genes in the absence of B-cell-specific octamer-binding factor , 1988, Molecular and cellular biology.

[66]  J. Strominger,et al.  Two distinct genetic loci regulating class II gene expression are defective in human mutant and patient cell lines. , 1988, The EMBO journal.

[67]  W. Reith,et al.  Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X , 1988, Cell.

[68]  G. Wong,et al.  Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells. , 1988, Journal of immunology.

[69]  N. Sigal,et al.  Regulation of class II MHC molecules on human endothelial cells. Effects of IFN and dexamethasone. , 1988, Journal of immunology.

[70]  C. Benoist,et al.  An enhancer factor defect in a mutant Burkitt lymphoma cell line , 1988, The Journal of experimental medicine.

[71]  B. Mach,et al.  Regulation of genes for HLA class II antigens in cell lines from patients with severe combined immunodeficiency. , 1988, The New England journal of medicine.

[72]  L. Glimcher,et al.  Corticosteroid induction of Ig+Ia- B cells in vitro is mediated via interaction with the glucocorticoid cytoplasmic receptor. , 1988, Journal of immunology.

[73]  L. Wahl,et al.  Analysis of Ia antigen expression in macrophages derived from bone marrow cells cultured in granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating factor. , 1988, Journal of immunology.

[74]  R. Palmiter,et al.  Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells , 1988, Cell.

[75]  J. Strominger,et al.  Active suppression of major histocompatibility complex class II gene expression during differentiation from B cells to plasma cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[76]  N. Sarvetnick,et al.  Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma , 1988, Cell.

[77]  A. Zlotnik,et al.  Induction of class I and class II MHC antigen expression on murine bone marrow-derived macrophages by IL-4 (B cell stimulatory factor 1). , 1988, Journal of immunology.

[78]  L. Harrison,et al.  IFN-gamma induces islet cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse. , 1988, Journal of immunology.

[79]  R. Accolla,et al.  Defective HLA class II expression in a regulatory mutant is partially complemented by activated ras oncogenes. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[80]  S. Pizzo,et al.  Modulation of mouse peritoneal macrophage Ia and human peritoneal macrophage HLA-DR expression by alpha 2-macroglobulin "fast" forms. , 1987, Journal of immunology.

[81]  C. Benoist,et al.  Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[82]  P. Morrissey,et al.  Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells. , 1987, Journal of immunology.

[83]  J. Guardiola,et al.  Distinct mechanisms regulate MHC class II gene expression in B cells and macrophages. , 1987, Journal of immunology.

[84]  R. Germain,et al.  Induction of macrophage Ia antigen expression by rIFN-gamma and down-regulation by IFN-alpha/beta and dexamethasone are mediated by changes in steady-state levels of Ia mRNA. , 1987, Journal of immunology.

[85]  T. Hamilton,et al.  Maleylated-BSA suppresses IFN-gamma-mediated Ia expression in murine peritoneal macrophages. , 1987, Journal of immunology.

[86]  T. Maniatis,et al.  Regulation of inducible and tissue-specific gene expression. , 1987, Science.

[87]  G. Sozzi,et al.  Differential susceptibility to recombinant interferon-gamma-induced HLA-DQ antigen modulation among clones from a human metastatic melanoma. , 1987, Journal of immunology.

[88]  M. Feldmann,et al.  HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin , 1987, Nature.

[89]  C. Auffray,et al.  HLA DR, DQ, and DP antigen expression in rheumatoid synovial cells: a biochemical and quantitative study. , 1987, Journal of immunology.

[90]  P. Scheurich,et al.  Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells. , 1987, Journal of immunology.

[91]  J. Strominger,et al.  Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[92]  W. Paul,et al.  Regulation of class II gene expression: analysis in B cell stimulatory factor 1-inducible murine pre-B cell lines. , 1986, Journal of immunology.

[93]  S. Lee,et al.  Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line. , 1986, Journal of immunology.

[94]  J. Guardiola,et al.  aIr-1, a newly found locus on mouse chromosome 16 encoding a trans- acting activator factor for MHC class II gene expression , 1986, The Journal of experimental medicine.

[95]  P. Herrlich,et al.  Interferon-gamma, mitomycin C, and cycloheximide as regulatory agents of MHC class II-associated invariant chain expression. , 1986, Journal of immunology.

[96]  P. Debré,et al.  Expression of MHC class II and Tac antigens on IL2-activated human T cell clones that can stimulate in MLR, AMLR, PLT and can present antigen. , 1986, Human immunology.

[97]  E. Unanue,et al.  Immune complex effects on murine macrophages. I. Immune complexes suppress interferon-gamma induction of Ia expression. , 1985, Journal of immunology.

[98]  B. Mach,et al.  A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes , 1985, Nature.

[99]  Eric O Long,et al.  DO beta: a new beta chain gene in HLA‐D with a distinct regulation of expression. , 1985, The EMBO journal.

[100]  H. Mcdevitt,et al.  In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[101]  S. Vogel,et al.  Antagonistic effect of interferon-beta on the interferon-gamma-induced expression of Ia antigen in murine macrophages. , 1985, Journal of immunology.

[102]  D. R. Gamble,et al.  In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. , 1985, The New England journal of medicine.

[103]  J. Parnes,et al.  Coordinate induction of Ia alpha, beta, and Ii mRNA in a macrophage cell line. , 1985, Journal of immunology.

[104]  G. Church,et al.  B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. , 1985, Science.

[105]  J. Lamb,et al.  Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells , 1984, Nature.

[106]  J. Uhr,et al.  Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[107]  W. Fiers,et al.  Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[108]  A. Houghton,et al.  Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon , 1984, The Journal of experimental medicine.

[109]  E. Unanue,et al.  α-fetoprotein inhibits macrophage expression of Ia antigens , 1984 .

[110]  J. Monroe,et al.  B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation. , 1984, Journal of immunology.

[111]  J. Monroe,et al.  B cell activation. III. B cell plasma membrane depolarization and hyper- Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled , 1983, The Journal of experimental medicine.

[112]  H. Mcdevitt,et al.  Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies , 1983, The Journal of experimental medicine.

[113]  M. Capobianchi,et al.  Differential effects of gamma interferon on expression of HLA class II molecules controlled by the DR and DC loci , 1983, Infection and immunity.

[114]  R. Accolla Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets , 1983, The Journal of experimental medicine.

[115]  J. Monroe,et al.  Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle. , 1983, Journal of immunology.

[116]  E. Unanue,et al.  Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. , 1982, Journal of immunology.

[117]  E. Unanue,et al.  Prostaglandins modulate macrophage Ia expression , 1982, Nature.

[118]  V. Kelley,et al.  Increase in macrophage Ia expression in autoimmune mice: role of the Ipr gene. , 1982, Journal of immunology.

[119]  F. Finkelman,et al.  Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface immunoglobulin. , 1981, Journal of immunology.

[120]  M. M. Garner,et al.  A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system , 1981, Nucleic Acids Res..

[121]  P. Marrack,et al.  Functional subsets of B cells defined by quantitative differences in surface I-A. , 1981, Journal of immunology.

[122]  P. Gladstone,et al.  Stable variants affecting B cell alloantigens in human lymphoid cells , 1978, Nature.

[123]  J. Darnell,et al.  Rapid in vivo footprinting technique identifies proteins bound to the TTR gene in the mouse liver. , 1991, Genes & development.

[124]  C. Benoist,et al.  Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet. , 1990 .

[125]  L. Glimcher,et al.  Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis. , 1989, The American journal of pathology.

[126]  R. Kennett,et al.  Expression of HLA-DR mRNA in T cells following activation is early and can precede DNA synthesis. , 1989, Autoimmunity.

[127]  M. Feldmann,et al.  A phenotypically dominant regulatory mechanism suppresses major histocompatibility complex class II gene expression in a murine plasmacytoma , 1987, European Journal of Immunology.

[128]  P. Cazenave,et al.  Phorbol ester induces class II gene expression in pre‐B cell lines , 1987, European journal of immunology.

[129]  G. Wong,et al.  Inducible expression of H–2 and Ia antigens on brain cells , 1984, Nature.

[130]  G. Nossal,et al.  Maturation of B lymphocytes. I. Concurrent appearance of increasing Ig, Ia, and mitogen responsiveness. , 1979, Journal of immunology.

[131]  B. Mach,et al.  Rapid A Defect in the Regulation of Major Histocompatibility Complex Class 11 Gene Expression in Human HLA-DR Negative Lymphocytes from Patients with Combined Immunodeficiency Syndrome , 2022 .