Frequent somatic mutations of GNAQ in uveal melanoma and blue nevi

[1]  M. Bittner,et al.  The Wnt5A/Protein Kinase C Pathway Mediates Motility in Melanoma Cells via the Inhibition of Metastasis Suppressors and Initiation of an Epithelial to Mesenchymal Transition* , 2007, Journal of Biological Chemistry.

[2]  Suzie Chen,et al.  Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilon. , 2006, Cellular signalling.

[3]  T. Golub,et al.  Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma , 2005, Nature.

[4]  N. Hayward,et al.  Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS , 2005, British Journal of Cancer.

[5]  Arun D. Singh,et al.  Uveal melanoma: epidemiologic aspects. , 2005, Ophthalmology clinics of North America.

[6]  M. Mihm,et al.  Dermal dendritic melanocytic proliferations: an update , 2004, Histopathology.

[7]  G. Saldanha,et al.  High BRAF mutation frequency does not characterize all melanocytic tumor types , 2004, International journal of cancer.

[8]  Helmut Fuchs,et al.  Effects of G-protein mutations on skin color , 2004, Nature Genetics.

[9]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[10]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[11]  S. Tilghman,et al.  The temporal requirement for endothelin receptor-B signalling during neural crest development , 1999, Nature.

[12]  R. Moon,et al.  Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in aG-protein-dependent manner , 1999, Current Biology.

[13]  L. Karnell,et al.  The National Cancer Data Base report on cutaneous and noncutaneous melanoma , 1998, Cancer.

[14]  M. Kawashima,et al.  Dormant melanocytes in the dermis: do dermal melanocytes of acquired dermal melanocytosis exist from birth? , 1998, The British journal of dermatology.

[15]  H. Bourne,et al.  Separate GTP binding and GTPase activating domains of a G alpha subunit. , 1993, Science.

[16]  D. Horsman,et al.  Cytogenetic analysis of uveal melanoma consistent occurrence of monosomy 3 and trisomy 8q , 1993, Cancer.

[17]  J. Gutkind,et al.  Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells , 1992, Molecular and cellular biology.

[18]  E. Kawasaki,et al.  Two G protein oncogenes in human endocrine tumors. , 1990, Science.

[19]  H. Bourne,et al.  GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours , 1989, Nature.

[20]  D. Bennett,et al.  A line of non‐tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth , 1987, International journal of cancer.

[21]  Daan Brandenbarg The National. , 1892 .

[22]  J. Stockman,et al.  Distinct Sets of Genetic Alterations in Melanoma , 2007 .

[23]  J. Hepler,et al.  Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. , 2006, Cellular signalling.

[24]  P. Meltzer,et al.  High frequency of BRAF mutations in nevi , 2003, Nature Genetics.

[25]  C. Tanner,et al.  Epidemiologic aspects. , 2000, Advances in neurology.

[26]  R. Elston,et al.  Lifetime prevalence of uveal melanoma in white patients with oculo(dermal) melanocytosis. , 1998, Ophthalmology.

[27]  K. Johnson An Update. , 1984, Journal of food protection.