Using mass spectrometry to characterize self-assembled monolayers presenting peptides, proteins, and carbohydrates.

Mass spectrometry (MS) is an important technique for characterizing the structures of surfaces and has several characteristics that are especially valuable in bioanalytical applications. In biochip applications, for example, MS offers the significant advantage that it does not require analytes to be labeled–either by direct attachment of fluorescent and radioactive labels or by binding of antibodies–and therefore offers greater flexibility in experiments.[1±4] Further, the use of immobilized ligands to isolate active proteins from the COMMUNICATIONS

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