Gold nanoparticles: recent aspects for human toxicology

Nanoparticles (particles sized between 1 and 100 nanometers) are more and more used in all fields of science and medicine for their physicochemical properties. As gold has traditionally been considered as chemically inert and biocompatible, in particular, gold nanoparticles have been established as valuable tools in several areas of biomedical research. But in contrast to the multitude of studies that addressed the clinical use of gold nanoparticles, only little is known about potential toxicological effects such as induction of inflammatory immune responses, possible apoptotic cell death or developmental growth inhibition in embryos. Therefore the present study performed a systematic review of toxicological data, especially experimentally acquired data concerning in-vivo-toxicity, published in the PubMed. It can be stated that the data in this area of research is still largely limited. Especially, knowledge about size-, charge- and surface-chemistry dependent in-vivo-toxicity is needed to predict the hazard potential of auric nanoparticles (AuNPs) for humans.

[1]  B. van Ravenzwaay,et al.  Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats. , 2012, Mutation research.

[2]  J. Conde,et al.  Gold-nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis , 2014, Nanotoxicology.

[3]  Xiu Shen,et al.  Size-dependent in vivo toxicity of PEG-coated gold nanoparticles , 2011, International journal of nanomedicine.

[4]  Seungpyo Hong,et al.  Nanoparticle interaction with biological membranes: does nanotechnology present a Janus face? , 2007, Accounts of chemical research.

[5]  Sónia Fraga,et al.  Influence of the surface coating on the cytotoxicity, genotoxicity and uptake of gold nanoparticles in human HepG2 cells , 2013, Journal of applied toxicology : JAT.

[6]  Elizabeth I. Maurer,et al.  Gold nanoparticles induce transcriptional activity of NF-κB in a B-lymphocyte cell line. , 2013, Nanoscale.

[7]  Michael Tseng,et al.  Toxicogenomic responses of the model organism Caenorhabditis elegans to gold nanoparticles. , 2012, Environmental science & technology.

[8]  F. Perreault,et al.  Toxicity of pamam‐coated gold nanoparticles in different unicellular models , 2014, Environmental toxicology.

[9]  E. Simanek.  Far-infrared absorption in ultrafine Al particles , 1977 .

[10]  John A Kalef-Ezra,et al.  Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma , 2010, Physics in medicine and biology.

[11]  Lisa Truong,et al.  Persistent adult zebrafish behavioral deficits results from acute embryonic exposure to gold nanoparticles. , 2012, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[12]  O. N. Oliveira,et al.  Probing the interaction of oppositely charged gold nanoparticles with DPPG and DPPC Langmuir monolayers as cell membrane models. , 2013, Colloids and surfaces. B, Biointerfaces.

[13]  Aibo Liu,et al.  Application of gold nanoparticles in biomedical researches and diagnosis. , 2013, Clinical laboratory.

[14]  B. Chung,et al.  Susceptibility to gold nanoparticle-induced hepatotoxicity is enhanced in a mouse model of nonalcoholic steatohepatitis. , 2012, Toxicology.

[15]  Oeca,et al.  National Environmental Policy Act , 1970, Current History.

[16]  Glenn R. Dickson,et al.  Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles , 2011, Scientific reports.

[17]  Hugh J Byrne,et al.  Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells. , 2010, Toxicology and applied pharmacology.

[18]  G. Vecchio,et al.  Mutagenic effects of gold nanoparticles induce aberrant phenotypes in Drosophila melanogaster. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[19]  Kevin Robbie,et al.  Nanomaterials and nanoparticles: Sources and toxicity , 2007, Biointerphases.

[20]  J. Hainfeld,et al.  The use of gold nanoparticles to enhance radiotherapy in mice. , 2004, Physics in medicine and biology.

[21]  A. Punnoose,et al.  The Influences of Cell Type and ZnO Nanoparticle Size on Immune Cell Cytotoxicity and Cytokine Induction , 2009, Nanoscale research letters.

[22]  May D. Wang,et al.  In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags , 2008, Nature Biotechnology.

[23]  Robert L. Tanguay,et al.  Gold nanoparticles disrupt zebrafish eye development and pigmentation. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[24]  Sabine Neuss,et al.  Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage. , 2009, Small.

[25]  E. Zubarev,et al.  Paclitaxel-functionalized gold nanoparticles. , 2007, Journal of the American Chemical Society.

[26]  R. Naik,et al.  Biologically tunable reactivity of energetic nanomaterials using protein cages. , 2013, Nano letters.