An alternative method for synthesis of the CC-1065 pharmacophore, 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one
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The synthesis of the CC-1065 pharmacophore, 2-(1-methylpyrrole-2-carbonyl)-1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (17), is described. The methods reported here provide an alternative route for the synthesis of compounds possessing the biologically active 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (Cl) functionality