The LH surge in humans: its mechanism and sex difference.

There is a sex difference in the response to an estrogen challenge test in humans, but, unlike with rats, this sex difference is not permanently imprinted in the central nervous system. Estrogen is not only the important ovarian signal to trigger off the LH surge, but it also probably plays an important role in activating the positive estrogen feedback mechanism in humans. For an LH surge to occur, amplification of the hypothalamic signal (enhanced secretion of GnRH) as well as sensitization of the pituitary responsiveness to GnRH are required. It is unlikely that androgens per se are responsible for suppressing the positive estrogen feedback in humans and the possible role of another gonadal factor other than androgens remains speculative. The LH surge is a neuroendocrine phenomenon involved primarily in the process of ovulation and it is not correlated to sexual identity and orientation. Furthermore, how the hypothalamic-pituitary axis (HPA) responds to the estrogen challenge can be accounted for purely by its exposure to a different steroid milieu without reference to gender identity or sexual orientation of the subject.

[1]  L. Gooren.  Reversal of the LH response to oestrogen administration after orchidectomy in a male subject with the androgen insensitivity syndrome. , 1987, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[2]  L. Gooren.  The neuroendocrine response of luteinizing hormone to estrogen administration in the human is not sex specific but dependent on the hormonal environment. , 1986, The Journal of clinical endocrinology and metabolism.

[3]  L. Gooren.  The neuroendocrine response of luteinizing hormone to estrogen administration in heterosexual, homosexual, and transsexual subjects. , 1986, The Journal of clinical endocrinology and metabolism.

[4]  S. Ratnam,et al.  Effects of sex steroids on the positive estrogen feedback mechanism in intact women and castrate men. , 1985, The Journal of clinical endocrinology and metabolism.

[5]  B. A. Gladue,et al.  Neuroendocrine response to estrogen and sexual orientation. , 1985, Science.

[6]  D. London,et al.  THE FEMINISATION OF GONADOTROPHIN RESPONSES IN INTACT MALE TRANSSEXUALS , 1984, Clinical endocrinology.

[7]  G. Hodgen,et al.  Blockade of the estrogen-induced luteinizing hormone surge in monkeys: a nonsteroidal, antigenic factor in porcine follicular fluid. , 1984, Fertility and sterility.

[8]  R. Schenken,et al.  Follicle-stimulating hormone induced ovarian hyperstimulation in monkeys: blockade of the luteinizing hormone surge. , 1983, The Journal of clinical endocrinology and metabolism.

[9]  A. Mancini,et al.  Estradiol modulation of basal and gonadotropin-releasing hormone-induced gonadotropin release in intact and castrated men. , 1983, Neuroendocrinology.

[10]  J. Marshall,et al.  GONADOTROPIN REGULATION DURING HUMAN PUBERTY12 , 1983 .

[11]  H. Spies,et al.  Reinitiation of ovulatory cycles in pituitary stalk-sectioned rhesus monkeys: evidence for a specific hypothalamic message for the preovulatory release of luteinizing hormone. , 1982, Endocrinology.

[12]  J. Marshall,et al.  Pulsatile secretion of luteinizing hormone in children. , 1982, The Journal of clinical endocrinology and metabolism.

[13]  L. de Marinis,et al.  Biphasic effect of estradiol on luteinizing hormone response to gonadotropin-releasing hormone in castrated men. , 1982, Metabolism: clinical and experimental.

[14]  R. Kelch,et al.  Subnormal gonadotropin responses to gonadotropin-releasing hormone persist into puberty in children with isolated growth hormone deficiency. , 1981, The Journal of clinical endocrinology and metabolism.

[15]  S. Ratnam,et al.  RECOVERY OF HYPOPHYSEAL‐TESTICULAR FUNCTION FROM SEX STEROID TREATMENT AND THE PITUITARY RESPONSE TO CASTRATION IN MALE TRANSSEXUALS , 1981, Clinical endocrinology.

[16]  E. Knobil,et al.  Patterns of hypophysiotropic signals and gonadotropin secretion in the rhesus monkey. , 1981, Biology of reproduction.

[17]  J. Marshall,et al.  Estimation of GnRH Pulse Amplitude during Pubertal Development , 1981, Pediatric Research.

[18]  A. Barbarino,et al.  Estrogen induction of luteinizing hormone release in castrated adult human males. , 1980, The Journal of clinical endocrinology and metabolism.

[19]  G. Dörner.  Sexual differentiation of the brain. , 1980, Vitamins and hormones.

[20]  F. Conte,et al.  Correlation of luteinizing hormone-releasing factor-induced luteinizing hormone and follicle-stimulating hormone release from infancy to 19 years with the changing pattern of gonadotropin secretion in agonadal patients: relation to the restraint of puberty. , 1980, The Journal of clinical endocrinology and metabolism.

[21]  A. Barbarino,et al.  PRESENCE OF POSITIVE FEEDBACK BETWEEN OESTROGEN AND LH IN PATIENTS WITH KLINEFELTER'S SYNDROME, AND SERTOLI‐CELL‐ONLY SYNDROME , 1979 .

[22]  R. L. Edwards,et al.  OESTROGEN AMPLIFICATION OF LH‐RH RESPONSE IN THE POLYCYSTIC OVARY SYNDROME AND RESPONSE TO CLOMIPHENE , 1978, Clinical endocrinology.

[23]  C. Gale,et al.  Luteinizing hormone regulation in the monkey (Macaca nemestrina): failure of testosterone and dihydrotestosterone to block the estrogen-induced gonadotropin surge. , 1978, Biology of reproduction.

[24]  E. Canalis,et al.  Abnormal gonadotropin secretory responses to LRH in transsexual women after diethylstilbestrol priming. , 1978, The Journal of clinical endocrinology and metabolism.

[25]  A. L. Goodman,et al.  Post partum patterns of circulating FSH, LH, prolactin, estradiol, and progesterone in nonsuckling cynomolgus monkeys , 1978, Steroids.

[26]  J. Young,et al.  Strength-duration characteristics of estrogen effects on gonadotropin response to gonadotropin-releasing hormone in women. II. Effects of varying concentrations of estradiol. , 1976, The Journal of clinical endocrinology and metabolism.

[27]  H. Kulin,et al.  Gonadotropin and Testosterone Measurements after Estrogen Administration to Adult Men, Prepubertal and Pubertal Boys, and Men with Hypogonadotropism: Evidence for Maturation of Positive Feedback in the Male , 1976, Pediatric Research.

[28]  R. Jaffe,et al.  Strength-duration characteristics of estrogen effects on gonadotropin response to gonadotropin-releasing hormone in women. I. Effects of varying duration of estradiol administration. , 1975, The Journal of clinical endocrinology and metabolism.

[29]  J. Bancroft,et al.  Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers. , 1975, The Journal of endocrinology.

[30]  D. London,et al.  THE OESTROGEN PROVOCATION TEST , 1975, Clinical endocrinology.

[31]  W. Rohde,et al.  A neuroendocrine predisposition for homosexuality in men , 1975, Archives of sexual behavior.

[32]  R. Penny,et al.  Variation in pituitary-gonadal function in adolescent male homosexuals and heterosexuals. , 1974, The Journal of clinical endocrinology and metabolism.

[33]  D. Mishell,et al.  Measurement of serum LH, FSH, progesterone, 17-hydroxy-progesterone and estradiol-17beta levels at 4-hour intervals during the periovulatory phase of the menstrual cycle. , 1974, The Journal of clinical endocrinology and metabolism.

[34]  J. Winter,et al.  Positive feedback effect of progestin upon serum gonadotropins in estrogen-primed castrate men. , 1973, The Journal of clinical endocrinology and metabolism.

[35]  D. Dierschke,et al.  Induced LH surges in the rhesus monkey: strength-duration characteristics of the estrogen stimulus. , 1973, Endocrinology.

[36]  F. Naftolin,et al.  Estrogen formation in the brain. , 1972, American journal of obstetrics and gynecology.

[37]  D. Dierschke,et al.  The negative feedback control by estradiol and progesterone of LH secretion in the ovariectomized rhesus monkey. , 1972, Endocrinology.

[38]  D. Mishell,et al.  Serum gonadotropin and steroid patterns during the normal menstrual cycle. , 1971, American journal of obstetrics and gynecology.

[39]  G. Dörner,et al.  Structural changes in the hypothalamic ventromedial nucleus of the male rat, following neonatal castration and androgen treatment. , 1969, Neuroendocrinology.

[40]  G. Dörner,et al.  Structural changes in the preoptic anterior hypothalamic area of the male rat, following neonatal castration and androgen substitution. , 1968, Neuroendocrinology.