Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer.
暂无分享,去创建一个
[1] Y. Iwamoto,et al. Involvement of P‐glycoprotein and MRP1 in resistance to cyclic tetrapeptide subfamily of histone deacetylase inhibitors in the drug‐resistant osteosarcoma and Ewing's sarcoma cells , 2006, International journal of cancer.
[2] R. Samulski,et al. Adeno-associated virus vectors: potential applications for cancer gene therapy , 2005, Cancer Gene Therapy.
[3] S. Kohno,et al. Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells. , 2005, Lung cancer.
[4] Roman Rouzier,et al. Phase II study of tariquidar, a selective P‐glycoprotein inhibitor, in patients with chemotherapy‐resistant, advanced breast carcinoma , 2005, Cancer.
[5] M. J. Newman,et al. A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer , 2005, Investigational New Drugs.
[6] D. Piwnica-Worms,et al. In vivo RNA Interference–Mediated Ablation of MDR1 P-Glycoprotein , 2005, Clinical Cancer Research.
[7] Francisco Gamarro,et al. Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. , 2005, Cancer research.
[8] S. Cole,et al. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. , 2005, Toxicology and applied pharmacology.
[9] R. Samulski,et al. Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[10] M. Izquierdo. Short interfering RNAs as a tool for cancer gene therapy , 2005, Cancer Gene Therapy.
[11] M. Morris,et al. FLAVONOIDS CHRYSIN AND BENZOFLAVONE, POTENT BREAST CANCER RESISTANCE PROTEIN INHIBITORS, HAVE NO SIGNIFICANT EFFECT ON TOPOTECAN PHARMACOKINETICS IN RATS OR MDR1A/1B (–/–) MICE , 2005, Drug Metabolism and Disposition.
[12] Michael J. Welch,et al. Imaging Multidrug Resistance P-glycoprotein Transport Function Using MicroPET with Technetium-94m-Sestamibi , 2005, Molecular imaging.
[13] A. Oza,et al. Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours , 2005, Cancer Chemotherapy and Pharmacology.
[14] S. Chong,et al. P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats , 2005, Cancer Chemotherapy and Pharmacology.
[15] W. T. Beck,et al. Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference. , 2004, Molecular cancer therapeutics.
[16] J. Rader,et al. Phase I Study of Docetaxel in Combination with the P-Glycoprotein Inhibitor, Zosuquidar, in Resistant Malignancies , 2004, Clinical Cancer Research.
[17] Mariël Brok,et al. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. , 2004, Blood.
[18] J. Schellens,et al. Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice , 2004, Investigational New Drugs.
[19] S. Steinberg,et al. A Phase I/II Study of Infusional Vinblastine with the P-Glycoprotein Antagonist Valspodar (PSC 833) in Renal Cell Carcinoma , 2004, Clinical Cancer Research.
[20] S. Raguz,et al. Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1 , 2004, Gene Therapy.
[21] C. Slapak,et al. A Phase I Trial of a Potent P-Glycoprotein Inhibitor, Zosuquidar Trihydrochloride (LY335979), Administered Intravenously in Combination with Doxorubicin in Patients with Advanced Malignancy , 2004, Clinical Cancer Research.
[22] R. Callaghan,et al. Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy. , 2004, European journal of cancer.
[23] S. Bates,et al. Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition , 2004, Cancer Research.
[24] H. Minderman,et al. Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023 , 2004, Cancer Chemotherapy and Pharmacology.
[25] R. Callaghan,et al. The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models , 2003, British Journal of Cancer.
[26] A. Harris,et al. A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979). , 2003, British journal of clinical pharmacology.
[27] C. Ramachandran,et al. Effect of MDR1 phosphorothioate antisense oligodeoxynucleotides in multidrug-resistant human tumor cell lines and xenografts. , 2003, Anticancer research.
[28] T. Fojo,et al. Increased 99mTc-sestamibi accumulation in normal liver and drug-resistant tumors after the administration of the glycoprotein inhibitor, XR9576. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[29] Varun Garg,et al. Safety and efficacy of the multidrug resistance inhibitor Incel (biricodar; VX-710) in combination with paclitaxel for advanced breast cancer refractory to paclitaxel. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[30] P. Choyke,et al. A Phase I study of infusional vinblastine in combination with the p‐glycoprotein antagonist PSC 833 (valspodar) , 2001, Cancer.
[31] P. Choyke,et al. Phase I study of infusional paclitaxel in combination with the P-glycoprotein antagonist PSC 833. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[32] P. Charlton,et al. In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. , 2001, Cancer research.
[33] M. J. Newman,et al. Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance. , 2000, Cancer research.
[34] D. Stuart,et al. A novel, long-circulating, and functional liposomal formulation of antisense oligodeoxynucleotides targeted against MDR1 , 2000, Cancer Gene Therapy.
[35] J. Hescheler,et al. Redox regulation of P‐glycoprotein‐mediated multidrug resistance in multicellular prostate tumor spheroids , 2000, International journal of cancer.
[36] S. Binkley,et al. Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. , 1999, The Journal of pharmacology and experimental therapeutics.
[37] A. Giaccia,et al. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. , 1998, Cancer research.
[38] J. Holland,et al. Reversal of multidrug resistance by a liposome-MDR1 ribozyme complex , 1998, Cancer Chemotherapy and Pharmacology.
[39] D. Hipfner,et al. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. , 1997, Molecular pharmacology.
[40] A. Dantzig,et al. Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. , 1996, Cancer research.