Advanced materials for drug delivery and biosensors based on magnetic label detection

Abstract Many traditional magnetic materials are not suitable for the increasing demands of microsensors for environmental control, biomedical applications, drug delivery, and homeland security. The design of magnetic biosensors can be based on different types of magnetic effects. The detection principles are measurements of the resistance, impedance, etc. in the absence and presence of magnetic nanoparticles. Variations in the measured parameters can be associated with either many individual molecular recognition events or with a specific uptake. Magnetic materials which could be used in magnetoimpedance based biosensors have been studied both for the sensitive element and for magnetic label. The self-assembling processes were observed in perpendicular field for different concentrations of the Dynabeads® M-480. Magnetic field controlled assembly is proposed for designing new composite materials which can be also useful to study the properties of the separate particles. The morphology of the particle agglomerates and dipolar chains in the external field can be controlled by using simultaneously two different suspensions of magnetic particles. A new concept is to define synergetic combinations of two or more nanostructures for the best performance.

[1]  G. A. Prinz,et al.  Detection of a micron-sized magnetic sphere using a ring-shaped anisotropic magnetoresistance-based sensor: A model for a magnetoresistance-based biosensor , 2002 .

[2]  Hugo Ferreira,et al.  Biodetection using magnetically labeled biomolecules and arrays of spin valve sensors (invited) , 2003 .

[3]  Ben O'Shaughnessy,et al.  Morphology selection of nanoparticle dispersions by polymer media. , 2002, Physical review letters.

[4]  Paul E. Sheehan,et al.  Design and Performance of GMR Sensors for the Detection of Magnetic Microbeads in Biosensors , 2003 .

[5]  Etienne,et al.  Giant magnetoresistance of (001)Fe/(001)Cr magnetic superlattices. , 1988, Physical review letters.

[6]  Mischa Megens,et al.  Magnetic biochips: a new option for sensitive diagnostics , 2005 .

[7]  G. Kurlyandskaya,et al.  Magnetic Dynabeads detection by sensitive element based on giant magnetoimpedance. , 2005, Biosensors & bioelectronics.

[8]  D. Ralph,et al.  Microwave oscillations of a nanomagnet driven by a spin-polarized current , 2003, Nature.

[9]  Carlos Luna,et al.  Multidomain to single-domain transition for uniform Co80Ni20 nanoparticles , 2003 .

[10]  Q. Pankhurst,et al.  Applications of magnetic nanoparticles in biomedicine , 2003 .

[11]  A P Turner,et al.  Biosensors--Sense and Sensitivity , 2000, Science.

[12]  Gil U. Lee,et al.  A biosensor based on magnetoresistance technology. , 1998, Biosensors & bioelectronics.

[13]  N. Evans,et al.  In vivo glucose monitoring: the clinical reality and the promise. , 2005, Biosensors & bioelectronics.

[14]  Ami E. Berkowitz,et al.  GIANT MAGNETIC FIELD DEPENDENT IMPEDANCE OF AMORPHOUS FECOSIB WIRE , 1994 .

[15]  G. Reiss,et al.  Magnetoresistive logic and biochip , 2004 .

[16]  P. Hawkins,et al.  A novel measuring system for the determination of paramagnetic particle labels for use in magneto-immunoassays. , 2001, Biosensors & bioelectronics.

[17]  Nathan Kohler,et al.  Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. , 2002, Biomaterials.

[18]  Single nanoparticle measurement techniques , 1999, cond-mat/9912107.

[19]  S. Kobe,et al.  Amorphe Ferro- und Ferrimagnetika , 1980 .

[20]  M. Donahue,et al.  Integrated microfluidic isolation platform for magnetic particle manipulation in biological systems , 2004 .

[21]  Craig A. Grimes,et al.  Encyclopedia of Sensors , 2006 .

[22]  V. Pott,et al.  Detection of a single magnetic microbead using a miniaturized silicon Hall sensor , 2002 .

[23]  Volodymyr Tarasenko,et al.  Detektion superparamagnetischer Marker mittels GMI-Sensorik (Detection of superparamagnetic markers with GMI-Sensors) , 2003 .