Increased incidence of acute nonlymphocytic leukemia following therapy in patients with small cell carcinoma of the lung.

A group of 158 patients with small cell carcinoma of the lung were followed for 174.5 person-years of observation to determine the risk of acute leukemia. Three cases of acute nonlymphocytic leukemia were observed at 2.3, 2.7, and 3.0 years. The relative risk of developing leukemia was 316 (95% confidence limit, 76-818) and the actuarial risk was 25% +/- 13% at 3.1 years. The relative risk for leukemia was significantly increased in these patients (p less than 0.0001).

[1]  R J Keehn,et al.  Leukemia and preleukemia after adjuvant treatment of gastrointestinal cancer with semustine (methyl-CCNU). , 1983, The New England journal of medicine.

[2]  M. Greene,et al.  Evidence of a treatment dose response in acute nonlymphocytic leukemias which occur after therapy of non-Hodgkin's lymphoma. , 1983, Cancer research.

[3]  M. Greene,et al.  Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: a study of five randomized clinical trials. , 1982, The New England journal of medicine.

[4]  B. Sikic,et al.  Patterns of failure in small cell carcinoma of the lung , 1982, Cancer.

[5]  D. Arthur,et al.  Leukemia occurring after treatment of small cell lung cancer. , 1982, Cancer treatment reports.

[6]  Coltman Ca,et al.  Second malignancies complicating Hodgkin's disease: a Southwest Oncology Group 10-year followup. , 1982 .

[7]  P G Smith,et al.  Mortality among patients with ankylosing spondylitis after a single treatment course with x rays. , 1982, British medical journal.

[8]  D. V. Van Echo,et al.  Combination chemotherapy for small cell carcinoma of the lung: continuous versus alternating non-cross-resistant combinations. , 1982, Cancer treatment reports.

[9]  J. Minna,et al.  Erythroleukemia and other hematologic complications of intensive therapy in long‐term survivors of small cell lung cancer , 1982 .

[10]  Newcomer Ln,et al.  Acute myelogenous leukemia after successful treatment of small cell carcinoma of the lung. , 1982 .

[11]  R. Magenis,et al.  Therapy‐related preleukemic syndrome , 1981, Cancer.

[12]  R. Livingston.  Small cell carcinoma of the lung. , 1980, Blood.

[13]  J. Minna,et al.  Treatment of small cell undifferentiated carcinoma of the lung: update of recent results. , 1980, Cancer treatment reports.

[14]  A. Santoro,et al.  Second malignancies in Hodgkin's disease: a complication of certain forms of treatment. , 1980, British medical journal.

[15]  N. Nissen,et al.  Acute non‐lymphocytic leukemia in patients with ovarian carcinoma following long‐term treatment with treosulfan (=dihydroxybusulfan) , 1980, Cancer.

[16]  A. Miller,et al.  The chemotherapy on plasma-cell myeloma and the incidence of acute leukemia. , 1979, The New England journal of medicine.

[17]  C. Bloomfield,et al.  Therapy‐related leukemia. A panmyelosis , 1979, Cancer.

[18]  Lerner Hj.  Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer. , 1978 .

[19]  G. Bagby,et al.  The preleukemic syndrome (hemopoietic dysplasia) , 1978, Cancer.

[20]  F. Rosner,et al.  Breast cancer and acute leukemia: Report of 24 cases and review of the literature , 1978, American journal of hematology.

[21]  E. Glatstein,et al.  Hematologic neoplasia in patients treated for Hodgkin's disease. , 1977, The New England journal of medicine.

[22]  J. Bertino,et al.  Acute nonlymphocytic leukemia. A delayed complication of Hodgkin's disease therapy: Analysis of 109 cases , 1977, Cancer.

[23]  R. Hoover,et al.  Acute leukemia after alkylating-agent therapy of ovarian cancer. , 1977, The New England journal of medicine.

[24]  R. Monson,et al.  Analysis of relative survival and proportional mortality. , 1974, Computers and biomedical research, an international journal.

[25]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .