Anaemia in kidney disease: harnessing hypoxia responses for therapy
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[1] T. Hagve,et al. [Anemia of chronic disease]. , 2017, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.
[2] R. Goldschmeding,et al. Diverse origins of the myofibroblast—implications for kidney fibrosis , 2015, Nature Reviews Nephrology.
[3] A. Kurtz,et al. Chronic hypoxia-inducible transcription factor-2 activation stably transforms juxtaglomerular renin cells into fibroblast-like cells in vivo. , 2015, Journal of the American Society of Nephrology : JASN.
[4] O. Gandrillon,et al. The role of spatial organization of cells in erythropoiesis , 2013, Journal of mathematical biology.
[5] J. Keldenich,et al. Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects , 2014, PloS one.
[6] W. Hiatt,et al. Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease , 2014, Vascular medicine.
[7] A. McMahon,et al. Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis , 2014, Stem cell reports.
[8] S. Rivella,et al. IDENTIFICATION OF ERYTHROFERRONE AS AN ERYTHROID REGULATOR OF IRON METABOLISM , 2014, Nature Genetics.
[9] S. Laurie,et al. HIF and pulmonary vascular responses to hypoxia. , 2014, Journal of applied physiology.
[10] R. Wenger,et al. A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression , 2014, Haematologica.
[11] Andrew P McMahon,et al. Cell-specific translational profiling in acute kidney injury. , 2014, The Journal of clinical investigation.
[12] M. Koury. Abnormal erythropoiesis and the pathophysiology of chronic anemia. , 2014, Blood reviews.
[13] W. Jelkmann,et al. Intolerability of cobalt salt as erythropoietic agent. , 2014, Drug testing and analysis.
[14] G. Semenza,et al. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. , 2014, Annual review of pathology.
[15] Masayuki Yamamoto,et al. Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis , 2013, Nature Communications.
[16] S. Ro,et al. [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues. , 2013, Bioorganic & medicinal chemistry letters.
[17] V. Nizet,et al. HIF isoforms in the skin differentially regulate systemic arterial pressure , 2013, Proceedings of the National Academy of Sciences.
[18] S. Ito,et al. Plasticity of renal erythropoietin-producing cells governs fibrosis. , 2013, Journal of the American Society of Nephrology : JASN.
[19] G. Semenza,et al. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. , 2013, The Journal of clinical investigation.
[20] K. Pantopoulos,et al. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation. , 2013, Blood.
[21] M. H. Rabinowitz,et al. Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses. , 2013, Journal of medicinal chemistry.
[22] Masayuki Yamamoto,et al. A mouse model of adult-onset anaemia due to erythropoietin deficiency , 2013, Nature Communications.
[23] K. Eckardt,et al. Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells. , 2013, Journal of the American Society of Nephrology : JASN.
[24] M. Gassmann,et al. HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis. , 2013, Blood.
[25] M. Hentze,et al. The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. , 2013, Cell metabolism.
[26] R. Tuder,et al. Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α. , 2013, Cell metabolism.
[27] V. Haase. Regulation of erythropoiesis by hypoxia-inducible factors. , 2013, Blood reviews.
[28] V. Haase,et al. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. , 2012, The Journal of clinical investigation.
[29] E. Savolainen,et al. Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis. , 2012, Blood.
[30] W. Kaelin,et al. Treatment of erythropoietin deficiency in mice with systemically administered siRNA. , 2012, Blood.
[31] T. Ganz,et al. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. , 2012, Blood.
[32] C. Peyssonnaux,et al. Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis , 2012, Haematologica.
[33] K. Duffy,et al. Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury. , 2012, American journal of physiology. Renal physiology.
[34] A. McMahon,et al. Mammalian kidney development: principles, progress, and projections. , 2012, Cold Spring Harbor perspectives in biology.
[35] E. Rankin,et al. The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO , 2012, Cell.
[36] Daniel Hidalgo,et al. Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways. , 2012, Blood.
[37] C. Peyssonnaux,et al. Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice. , 2012, Blood.
[38] Brian Keith,et al. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression , 2011, Nature Reviews Cancer.
[39] Daniel Bilbao,et al. FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors , 2011, The EMBO journal.
[40] B. Krock,et al. Hypoxia-induced angiogenesis: good and evil. , 2011, Genes & cancer.
[41] S. Anand,et al. Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. , 2011, The Journal of clinical investigation.
[42] Tatiana Ammosova,et al. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. , 2011, Blood.
[43] L. Jorde,et al. Genetic determinants of Tibetan high-altitude adaptation , 2011, Human Genetics.
[44] Masayuki Yamamoto,et al. Isolation and Characterization of Renal Erythropoietin-Producing Cells from Genetically Produced Anemia Mice , 2011, PloS one.
[45] H. Okano,et al. Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. , 2011, The Journal of clinical investigation.
[46] T. Rouault,et al. Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts. , 2011, Blood.
[47] M. Siatecka,et al. The multifunctional role of EKLF/KLF1 during erythropoiesis. , 2011, Blood.
[48] Tetsuhiro Tanaka,et al. Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner , 2011, Laboratory Investigation.
[49] J. Aragonés,et al. Acute Vhl Gene Inactivation Induces Cardiac HIF-Dependent Erythropoietin Gene Expression , 2011, PloS one.
[50] K. Jishage,et al. Specific Contribution of the Erythropoietin Gene 3′ Enhancer to Hepatic Erythropoiesis after Late Embryonic Stages , 2011, Molecular and Cellular Biology.
[51] Y. Liu,et al. Negative Autoregulation by Fas Stabilizes Adult Erythropoiesis and Accelerates Its Stress Response , 2011, PloS one.
[52] Jiannis Ragoussis,et al. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. , 2011, Blood.
[53] F. Gonzalez,et al. Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. , 2011, Gastroenterology.
[54] S. Bembenek,et al. Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor , 2011, Molecular Pharmacology.
[55] R. Paulson,et al. Stress erythropoiesis: new signals and new stress progenitor cells , 2011, Current opinion in hematology.
[56] P. Ney. Normal and disordered reticulocyte maturation , 2011, Current opinion in hematology.
[57] M. Percy,et al. The HIF pathway and erythrocytosis. , 2011, Annual review of pathology.
[58] A. M. de Bruin,et al. Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis. , 2010, Blood.
[59] C. Schofield,et al. Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. , 2011, Trends in biochemical sciences.
[60] C. Beaumont,et al. Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation. , 2010, Blood.
[61] A. Besarab,et al. Iron supplementation to treat anemia in patients with chronic kidney disease , 2010, Nature Reviews Nephrology.
[62] R. Schmieder,et al. Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. , 2010, Journal of the American Society of Nephrology : JASN.
[63] P. Ratcliffe,et al. Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors , 2010, The Journal of Biological Chemistry.
[64] J. Epstein,et al. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. , 2010, Blood.
[65] M. Rämet,et al. Deficiency of a Transmembrane Prolyl 4-Hydroxylase in the Zebrafish Leads to Basement Membrane Defects and Compromised Kidney Function* , 2010, The Journal of Biological Chemistry.
[66] W. Kaelin,et al. Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss , 2010, Science.
[67] Y. Pei. Of mice and men: therapeutic mTOR inhibition in polycystic kidney disease. , 2010, Journal of the American Society of Nephrology : JASN.
[68] E. Morrisey,et al. The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. , 2010, The Journal of clinical investigation.
[69] S. Bachmann,et al. Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization. , 2010, Kidney international.
[70] R. Garrick. A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease , 2010 .
[71] A. McMahon,et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. , 2010, The American journal of pathology.
[72] D. Kleinfeld,et al. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. , 2009, The Journal of clinical investigation.
[73] V. Haase. Pathophysiological Consequences of HIF Activation , 2009, Annals of the New York Academy of Sciences.
[74] O. Djurdjev,et al. Hemoglobin variability in nondialysis chronic kidney disease: examining the association with mortality. , 2009, Clinical journal of the American Society of Nephrology : CJASN.
[75] T. Rouault,et al. A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. , 2009, Cell metabolism.
[76] B. Buchholz,et al. HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. , 2009, The American journal of pathology.
[77] R. Paus,et al. Erythropoietin and the skin: a role for epidermal oxygen sensing? , 2009, BioEssays : news and reviews in molecular, cellular and developmental biology.
[78] J. Yee,et al. What is so bad about a hemoglobin level of 12 to 13 g/dL for chronic kidney disease patients anyway? , 2009, Advances in chronic kidney disease.
[79] K. Kalantar-Zadeh,et al. Intravenous iron versus erythropoiesis-stimulating agents: friends or foes in treating chronic kidney disease anemia? , 2009, Advances in chronic kidney disease.
[80] F. Gonzalez,et al. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. , 2009, Cell metabolism.
[81] Jerry Kaplan,et al. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. , 2008, Cell metabolism.
[82] D. Brenner,et al. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. , 2008, The American journal of pathology.
[83] M. Celeste Simon,et al. The impact of O2 availability on human cancer , 2008, Nature Reviews Cancer.
[84] David W. Smith,et al. Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis. , 2008, American journal of physiology. Renal physiology.
[85] N. Mohandas,et al. Erythroblastic islands: niches for erythropoiesis. , 2008, Blood.
[86] W. Kaelin,et al. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. , 2008, Molecular cell.
[87] B. Beutler,et al. The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency , 2008, Science.
[88] Masayuki Yamamoto,et al. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. , 2008, Blood.
[89] B. D. de Pauw,et al. Erythrocyte vesiculation: a self‐protective mechanism? , 2008, British journal of haematology.
[90] Kai-Uwe Eckardt,et al. Epidermal Sensing of Oxygen Is Essential for Systemic Hypoxic Response , 2008, Cell.
[91] W. Kaelin,et al. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. , 2008, Blood.
[92] K. Takeda,et al. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. , 2008, Blood.
[93] Christopher J Schofield,et al. Expanding chemical biology of 2-oxoglutarate oxygenases. , 2008, Nature chemical biology.
[94] Clara Camaschella,et al. Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. , 2008, Blood.
[95] M. McMullin,et al. A gain-of-function mutation in the HIF2A gene in familial erythrocytosis. , 2008, The New England journal of medicine.
[96] Y. Fujii‐Kuriyama,et al. The microenvironment for erythropoiesis is regulated by HIF-2α through VCAM-1 in endothelial cells. Commentary , 2008 .
[97] S. Nagata. Autoimmune diseases caused by defects in clearing dead cells and nuclei expelled from erythroid precursors , 2007, Immunological reviews.
[98] M. Laugsch,et al. Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[99] J. Tisdale,et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. , 2007, Blood.
[100] Kazuhiro Iwai,et al. Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1 , 2007, Molecular and Cellular Biology.
[101] V. Nizet,et al. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). , 2007, The Journal of clinical investigation.
[102] D. Webb,et al. Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude. , 2007, Chest.
[103] E. Rankin,et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. , 2007, The Journal of clinical investigation.
[104] Jane-Jane Chen. Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. , 2007, Blood.
[105] J. Arias-Stella,et al. The Heart and Pulmonary Circulation at High Altitudes: Healthy Highlanders and Chronic Mountain Sickness , 2007, Circulation.
[106] W. Jelkmann. Erythropoietin after a century of research: younger than ever , 2007, European journal of haematology.
[107] R. Johnson,et al. Acute postnatal ablation of Hif-2α results in anemia , 2007, Proceedings of the National Academy of Sciences.
[108] T. Ganz. Molecular control of iron transport. , 2007, Journal of the American Society of Nephrology : JASN.
[109] R. Johnson,et al. Acute postnatal ablation of Hif-2alpha results in anemia. , 2007, Proceedings of the National Academy of Sciences of the United States of America.
[110] S. Mujais,et al. Erythropoietin is produced by tubular cells of the rat kidney , 2007, Cell Biochemistry and Biophysics.
[111] J. Manson,et al. Prospective Study of , 2007 .
[112] H. Burger,et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. , 2006, The New England journal of medicine.
[113] Huiman Barnhart,et al. Correction of anemia with epoetin alfa in chronic kidney disease. , 2006, The New England journal of medicine.
[114] G. Semenza,et al. Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development* , 2006, Journal of Biological Chemistry.
[115] T. Rouault. The role of iron regulatory proteins in mammalian iron homeostasis and disease , 2006, Nature chemical biology.
[116] V. Haase. Hypoxia-inducible factors in the kidney. , 2006, American journal of physiology. Renal physiology.
[117] M. Nangaku,et al. Pathogenesis of renal anemia. , 2006, Seminars in nephrology.
[118] M. Socolovsky,et al. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. , 2006, Blood.
[119] Manuela Baccarini,et al. A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation. , 2006, Blood.
[120] Harvey F Lodish,et al. Cellular Trafficking and Degradation of Erythropoietin and Novel Erythropoiesis Stimulating Protein (NESP)* , 2006, Journal of Biological Chemistry.
[121] M. McMullin,et al. A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[122] M. Koury. Erythropoietin: the story of hypoxia and a finely regulated hematopoietic hormone. , 2005, Experimental hematology.
[123] G. Camenisch,et al. Integration of Oxygen Signaling at the Consensus HRE , 2005, Science's STKE.
[124] P. Kopsombut,et al. Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin. , 2005, Blood.
[125] J. Hogenesch,et al. Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells. , 2005, Physiological genomics.
[126] M. Biffoni,et al. Multiple Members of the TNF Superfamily Contribute to IFN-γ-Mediated Inhibition of Erythropoiesis1 , 2005, The Journal of Immunology.
[127] H. Pagel,et al. Is the renal production of erythropoietin controlled by the brain stem? , 2005, American journal of physiology. Endocrinology and metabolism.
[128] Y. Yoshikawa,et al. A novel mechanism in suppression of erythropoiesis during inflammation: a crucial role of RCAS1 , 2005, European journal of haematology.
[129] J. Richardson,et al. HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. , 2005, Blood.
[130] D. Barber,et al. Turning cells red: signal transduction mediated by erythropoietin. , 2005, Trends in cell biology.
[131] C. Dubois,et al. Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1 , 2005, Journal of Biological Chemistry.
[132] G. Semenza,et al. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. , 2005, Blood.
[133] Alessia Calzolari,et al. Expression of alternative transcripts of ferroportin-1 during human erythroid differentiation. , 2005, Haematologica.
[134] Jerry Kaplan,et al. Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization , 2004, Science.
[135] J. Prchal,et al. Regulation of ferrochelatase gene expression by hypoxia. , 2004, Life sciences.
[136] Elizabeta Nemeth,et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. , 2004, The Journal of clinical investigation.
[137] K. Pantopoulos. Iron Metabolism and the IRE/IRP Regulatory System: An Update , 2004, Annals of the New York Academy of Sciences.
[138] M. Brand,et al. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[139] A. Chapman-Smith,et al. The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. , 2004, The international journal of biochemistry & cell biology.
[140] J. D. Engel,et al. Hepatic Erythropoietin Gene Regulation by GATA-4* , 2004, Journal of Biological Chemistry.
[141] J. Sargent,et al. Iron Requirements in Hemodialysis , 2004, Blood Purification.
[142] M. A. Morris,et al. The HIF family member EPAS 1 / HIF-2 is required for normal hematopoiesis in mice , 2003 .
[143] Y. Fujii‐Kuriyama,et al. HLF/HIF‐2α is a key factor in retinopathy of prematurity in association with erythropoietin , 2003, The EMBO journal.
[144] V. Jorgetti,et al. IL-1beta, TNF-alpha, TGF-beta, and bFGF expression in bone biopsies before and after parathyroidectomy. , 2003, Kidney international.
[145] R. Johnson,et al. Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. , 2003, Gene expression.
[146] M. Gassmann,et al. Hypoxic up-regulation of erythroid 5-aminolevulinate synthase. , 2003, Blood.
[147] Gaël Nicolas,et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. , 2002, The Journal of clinical investigation.
[148] T. Iwanaga,et al. Epididymis is a novel site of erythropoietin production in mouse reproductive organs. , 2002, Biochemical and biophysical research communications.
[149] Christopher J. Schofield,et al. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL , 2002, Nature.
[150] M. Wener,et al. Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemia. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[151] M. Koury,et al. New insights into erythropoiesis , 2002, Current opinion in hematology.
[152] E. Swenson,et al. Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels , 2002, The Lancet.
[153] D. Andress,et al. Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. , 2002, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
[154] H. Lodish,et al. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. , 2001, Molecular cell.
[155] M. Gassmann,et al. Erythropoietin expression in primary rat Sertoli and peritubular myoid cells. , 2001, Blood.
[156] S. McKnight,et al. A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF , 2001, Science.
[157] Michael I. Wilson,et al. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation , 2001, Cell.
[158] P. Ratcliffe,et al. Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation , 2001, The EMBO journal.
[159] S. White,et al. HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[160] M. Ivan,et al. HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing , 2001, Science.
[161] Michael I. Wilson,et al. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation , 2001, Science.
[162] G. Semenza. HIF-1 and mechanisms of hypoxia sensing. , 2001, Current opinion in cell biology.
[163] I. Macdougall,et al. Role of uremic toxins in exacerbating anemia in renal failure. , 2001, Kidney international. Supplement.
[164] J. Fandrey,et al. Erythropoietin gene expression in different areas of the developing human central nervous system. , 2000, Brain research. Developmental brain research.
[165] H. Mohrenweiser,et al. Production and processing of erythropoietin receptor transcripts in brain. , 2000, Brain research. Molecular brain research.
[166] B. Mazumder,et al. Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency* , 2000, The Journal of Biological Chemistry.
[167] J. Cook,et al. Effects of erythropoietin therapy on iron absorption in chronic renal failure. , 2000, The Journal of laboratory and clinical medicine.
[168] S. Masuda,et al. The oviduct produces erythropoietin in an estrogen- and oxygen-dependent manner. , 2000, American journal of physiology. Endocrinology and metabolism.
[169] E. Mackenzie,et al. Neurons and astrocytes express EPO mRNA: Oxygen‐sensing mechanisms that involve the redox‐state of the brain , 2000, Glia.
[170] Avid,et al. THE EFFECTS OF NORMAL AS COMPARED WITH LOW HEMATOCRIT VALUES IN PATIENTS WITH CARDIAC DISEASE WHO ARE RECEIVING HEMODIALYSIS AND EPOETIN , 2000 .
[171] C. Kellendonk,et al. The glucocorticoid receptor is required for stress erythropoiesis. , 1999, Genes & development.
[172] M. Simon,et al. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. , 1999, Genes & development.
[173] L. Bianchi,et al. Transferrin Receptor Induction by Hypoxia , 1999, The Journal of Biological Chemistry.
[174] C. Lok,et al. Identification of a Hypoxia Response Element in the Transferrin Receptor Gene* , 1999, The Journal of Biological Chemistry.
[175] I. Wilson,et al. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. , 1999, Science.
[176] G. Stassi,et al. Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. , 1999, Blood.
[177] G. Semenza,et al. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. , 1999, Annual review of cell and developmental biology.
[178] M. Zenke,et al. Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro. , 1998, Blood.
[179] S. Masuda,et al. Estrogen-dependent Production of Erythropoietin in Uterus and Its Implication in Uterine Angiogenesis* , 1998, The Journal of Biological Chemistry.
[180] R. Fudin,et al. Correction of Uremic Iron Deficiency Anemia in Hemodialyzed Patients: A Prospective Study , 1998, Nephron.
[181] J. Price,et al. Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis. , 1998, Blood.
[182] J. Fandrey,et al. Erythropoietin mRNA expression in human fetal and neonatal tissue. , 1998, Blood.
[183] W. Jelkmann,et al. Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats. , 1997, The American journal of physiology.
[184] M. Gassmann,et al. Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1* , 1997, The Journal of Biological Chemistry.
[185] H. Lin,et al. Electron microscopic localization of lacZ expression in the proximal convoluted tubular cells of the kidney in transgenic mice carrying chimeric erythropoietin/lacZ gene constructs. , 1997, Journal of structural biology.
[186] G. Semenza,et al. Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia* , 1997, The Journal of Biological Chemistry.
[187] M. Gassmann,et al. Detection of erythropoietin in human liquor: intrinsic erythropoietin production in the brain. , 1997, Kidney international.
[188] P. Ponka. Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. , 1997, Blood.
[189] I. Macdougall,et al. A randomized controlled study of iron supplementation in patients treated with erythropoietin. , 1996, Kidney international.
[190] M. Gassmann,et al. Erythropoietin Gene Expression in Human, Monkey and Murine Brain , 1996, The European journal of neuroscience.
[191] Rudolf Jaenisch,et al. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor , 1995, Cell.
[192] K. Penta,et al. Erythropoietin cell biology. , 1994, Hematology/oncology clinics of North America.
[193] H. Lin,et al. Transgenic mice carrying the erythropoietin gene promoter linked to lacZ express the reporter in proximal convoluted tubule cells after hypoxia. , 1994, Blood.
[194] P. Ratcliffe,et al. Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells. , 1994, Blood.
[195] G. Semenza,et al. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. , 1993, Blood.
[196] P. Ratcliffe,et al. Identification of the renal erythropoietin-producing cells using transgenic mice. , 1993, Kidney international.
[197] M. Koury,et al. Survival or death of individual proerythroblasts results from differing erythropoietin sensitivities: a mechanism for controlled rates of erythrocyte production. , 1993, Blood.
[198] K. Muta,et al. Apoptosis of human erythroid colony‐forming cells is decreased by stem cell factor and insulin‐like growth factor I as well as erythropoietin , 1993, Journal of cellular physiology.
[199] O. Silvennoinen,et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin , 1993, Cell.
[200] G. Semenza,et al. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[201] H. Lodish,et al. Structure, function, and activation of the erythropoietin receptor. , 1993, Blood.
[202] M. Le Hir,et al. Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin. , 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[203] J. Fandrey,et al. In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. , 1993, Blood.
[204] W. Jelkmann. Erythropoietin: structure, control of production, and function. , 1992, Physiological reviews.
[205] S. Antonarakis,et al. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[206] G. Semenza,et al. Localization of cells producing erythropoietin in murine liver by in situ hybridization. , 1991, Blood.
[207] M. Goldberg,et al. Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. , 1991, Blood.
[208] B J Barnum,et al. On good and evil. , 1991, Nursing & health care : official publication of the National League for Nursing.
[209] S. Piantadosi,et al. Decreased erythropoietin response in patients with the anemia of cancer. , 1990, The New England journal of medicine.
[210] M. Koury,et al. Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. , 1990, Science.
[211] A. Maxwell,et al. Erythropoietin production in kidney tubular cells , 1990, British journal of haematology.
[212] S. Antonarakis,et al. Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements , 1990, Molecular and cellular biology.
[213] M. Koury,et al. Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration , 1989 .
[214] K. Eckardt,et al. Regulation of erythropoietin production is related to proximal tubular function. , 1989, The American journal of physiology.
[215] S. Antonarakis,et al. Polycythemia in transgenic mice expressing the human erythropoietin gene. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[216] K. Eckardt,et al. Single-dose pharmacokinetics of recombinant human erythropoietin in patients with various degrees of renal failure. , 1989, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[217] R. Weinmann,et al. Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. , 1989, Blood.
[218] M. Koury,et al. Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration. , 1989, Blood.
[219] M. Koury,et al. Maintenance by erythropoietin of viability and maturation of murine erythroid precursor cells , 1988, Journal of cellular physiology.
[220] F. Wendling,et al. Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. , 1988, The Journal of clinical investigation.
[221] M. Koury,et al. Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. , 1988, Blood.
[222] M A Goldberg,et al. The regulated expression of erythropoietin by two human hepatoma cell lines. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[223] E. Goldwasser,et al. Blunted erythropoietin response to anaemia in rheumatoid arthritis , 1987, British journal of haematology.
[224] K. Johnson. An Update. , 1984, Journal of food protection.
[225] A. Eaves,et al. Human marrow cells capable of erythropoietic differentiation in vitro: definition of three erythroid colony responses. , 1977, Blood.
[226] W. Fried. The liver as a source of extrarenal erythropoietin production. , 1972, Blood.
[227] M. S. Edwards,et al. Use of cobaltous chloride in anaemia of maintenance hemodialysis patients. , 1971, Lancet.
[228] W. Fried,et al. Studies on extrarenal erythropoietin. , 1969, The Journal of laboratory and clinical medicine.
[229] E. Goldwasser,et al. Studies on erythropoiesis. V. The effect of cobalt on the production of erythropoietin. , 1958, Blood.
[230] E. Goldwasser,et al. Mechanism of the erythropoietic effect of cobalt. , 1957, Science.
[231] E. Goldwasser,et al. Role of the Kidney in Erythropoiesis , 1957, Nature.