Pharmacogenomics of G protein-coupled receptor signaling: insights from health and disease.

[1]  A. Sitaramayya Introduction to Cellular Signal Transduction , 2012, Hormones in Health and Disease.

[2]  M. Thompson,et al.  Cysteinyl‐leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trends , 2007, Medicinal research reviews.

[3]  Yuan-sheng Gao,et al.  Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[4]  R. Felder,et al.  Mechanisms of Disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity , 2006, Nature Clinical Practice Nephrology.

[5]  R. Felder,et al.  D1 dopamine receptor hyperphosphorylation in renal proximal tubules in hypertension. , 2006, Kidney international.

[6]  M. Cismowski Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins). , 2006, Seminars in cell & developmental biology.

[7]  A. Avogaro,et al.  Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II , 2006, Journal of hypertension.

[8]  Min Chen,et al.  Genetic diseases associated with heterotrimeric G proteins. , 2006, Trends in pharmacological sciences.

[9]  E. Eskin,et al.  Polymorphisms and Haplotypes of the Regulator of G Protein Signaling-2 Gene in Normotensives and Hypertensives , 2006, Hypertension.

[10]  D. Sibley,et al.  The D1 Dopamine Receptor Is Constitutively Phosphorylated by G Protein-Coupled Receptor Kinase 4 , 2006, Molecular Pharmacology.

[11]  W. Chilian,et al.  Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[12]  R. Görges,et al.  Different genotype distribution of the GNB3 C825T polymorphism of the G protein β3 subunit in adenomas and differentiated thyroid carcinomas of follicular cell origin , 2005, The Journal of pathology.

[13]  P. Insel,et al.  Genetic variation in G-protein-coupled receptors – consequences for G-protein-coupled receptors as drug targets , 2005, Expert opinion on therapeutic targets.

[14]  M. Klintschar,et al.  DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes: association with unexpected death from acute myocardial infarction and increased heart weight. , 2005, Forensic science international.

[15]  J. Lieberman,et al.  Suggestive association between the C825T polymorphism of the G-protein β3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia , 2005, European Neuropsychopharmacology.

[16]  T. Berg,et al.  GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection. , 2005, Journal of hepatology.

[17]  P. Amouyel,et al.  Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. , 2005, Molecular genetics and metabolism.

[18]  D. Rosskopf,et al.  Association study of the G-protein β3 subunit C825T polymorphism with disease progression in patients with bladder cancer , 2005, World Journal of Urology.

[19]  C. Pepine,et al.  Association between β-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study , 2005, International Journal of Obesity.

[20]  A. Mitchell,et al.  Insulin‐mediated Venodilation is Impaired in Young, Healthy Carriers of the 825T Allele of the G‐protein β3 Subunit Gene (GNB3) , 2005, Clinical pharmacology and therapeutics.

[21]  Anne E Carpenter,et al.  Cell microarrays and RNA interference chip away at gene function , 2005, Nature Genetics.

[22]  T. Moritani,et al.  Association of C825T polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy Japanese individuals. , 2005, American journal of hypertension.

[23]  P. Frossard,et al.  Association of G-protein beta-3 subunit gene (GNB3) T825 allele with Type II diabetes. , 2005, Neuro endocrinology letters.

[24]  P. Insel,et al.  Multi-tasking RGS proteins in the heart: the next therapeutic target? , 2005, Circulation research.

[25]  U. Frey,et al.  Quantification of allele-specific G-protein β3 subunit mRNA transcripts in different human cells and tissues by Pyrosequencing , 2005, European Journal of Human Genetics.

[26]  Xiaoguang Sun,et al.  RGS2 Is a Mediator of Nitric Oxide Action on Blood Pressure and Vasoconstrictor Signaling , 2005, Molecular Pharmacology.

[27]  M. Thompson,et al.  The G protein-coupled receptors: Pharmacogenetics and Disease , 2005, Critical reviews in clinical laboratory sciences.

[28]  Min Chen,et al.  Chondrocyte‐Specific Knockout of the G Protein Gsα Leads to Epiphyseal and Growth Plate Abnormalities and Ectopic Chondrocyte Formation , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[29]  H. Lother,et al.  Factor XIIIA Transglutaminase Crosslinks AT1 Receptor Dimers of Monocytes at the Onset of Atherosclerosis , 2004, Cell.

[30]  L. Weinstein,et al.  Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[31]  M. von Zastrow,et al.  Identification of a Novel Endocytic Recycling Signal in the D1 Dopamine Receptor* , 2004, Journal of Biological Chemistry.

[32]  R. Lefkowitz Historical review: a brief history and personal retrospective of seven-transmembrane receptors. , 2004, Trends in pharmacological sciences.

[33]  Antonio S. Tutor,et al.  Polymorphism in genes involved in adrenergic signaling associated with Alzheimer’s , 2004, Neurobiology of Aging.

[34]  E. Codner,et al.  Activating GNAS1 gene mutations in patients with premature thelarche. , 2004, The Journal of pediatrics.

[35]  G. Ceolotto,et al.  Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter's/Gitelman's syndrome. A role in the control of vascular tone and implication for hypertension. , 2004, The Journal of clinical endocrinology and metabolism.

[36]  Graeme Milligan,et al.  G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology , 2004, Molecular Pharmacology.

[37]  Marc G Caron,et al.  Desensitization of G protein-coupled receptors and neuronal functions. , 2004, Annual review of neuroscience.

[38]  A. Levey,et al.  RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling* , 2004, Journal of Biological Chemistry.

[39]  B. O'dowd,et al.  Minireview: Diversity and complexity of signaling through peptidergic G protein-coupled receptors. , 2004, Endocrinology.

[40]  D. Sibley,et al.  The Role of Phosphorylation in D1 Dopamine Receptor Desensitization , 2004, Journal of Biological Chemistry.

[41]  L. Weinstein,et al.  Inherited diseases involving g proteins and g protein-coupled receptors. , 2004, Annual review of medicine.

[42]  Christopher M. Tan,et al.  Membrane trafficking of G protein-coupled receptors. , 2004, Annual review of pharmacology and toxicology.

[43]  Jilly F. Evans,et al.  A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. , 2003, Pharmacogenetics.

[44]  K. Austen,et al.  Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[45]  L. Weinstein,et al.  The Stimulatory G Protein α-Subunit Gsα Is Imprinted in Human Thyroid Glands: Implications for Thyroid Function in Pseudohypoparathyroidism Types 1A and 1B , 2003 .

[46]  P. Chidiac,et al.  Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions. , 2003, Molecular pharmacology.

[47]  E. Menis,et al.  Growth Hormone-Releasing Hormone Resistance in Pseudohypoparathyroidism Type Ia: New Evidence for Imprinting of the Gsα Gene , 2003 .

[48]  J. Hepler RGS protein and G protein interactions: a little help from their friends. , 2003, Molecular pharmacology.

[49]  M. Levine,et al.  Growth hormone deficiency in pseudohypoparathyroidism type 1a: another manifestation of multihormone resistance. , 2003, The Journal of clinical endocrinology and metabolism.

[50]  B. O'dowd,et al.  D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4. , 2003, Biochemistry.

[51]  J. Palmblad,et al.  Dominant Expression of the CysLT2 Receptor Accounts for Calcium Signaling by Cysteinyl Leukotrienes in Human Umbilical Vein Endothelial Cells , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[52]  A. Latronico,et al.  Cushing's syndrome secondary to adrenocorticotropin-independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene. , 2003, The Journal of clinical endocrinology and metabolism.

[53]  R. Soberman The expanding network of redox signaling: new observations, complexities, and perspectives. , 2003, The Journal of clinical investigation.

[54]  J. M. Wyss,et al.  Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. , 2003, The Journal of clinical investigation.

[55]  Ravi Iyengar,et al.  Modeling Signaling Networks , 2002, Science.

[56]  R. Lefkowitz,et al.  Regulation of G protein-coupled receptor signaling by scaffold proteins. , 2002, Circulation research.

[57]  P. Beck‐Peccoz,et al.  The gsalpha gene: predominant maternal origin of transcription in human thyroid gland and gonads. , 2002, The Journal of clinical endocrinology and metabolism.

[58]  M. Saji,et al.  Paternal imprinting of Galpha(s) in the human thyroid as the basis of TSH resistance in pseudohypoparathyroidism type 1a. , 2002, Biochemical and biophysical research communications.

[59]  B. O'dowd,et al.  Distinct Residues in the Carboxyl Tail Mediate Agonist-induced Desensitization and Internalization of the Human Dopamine D1 Receptor* , 2002, The Journal of Biological Chemistry.

[60]  C. K. Chen,et al.  Characterization of human GRK7 as a potential cone opsin kinase. , 2001, Molecular vision.

[61]  W. Siffert Molecular genetics of G proteins and atherosclerosis risk , 2001, Basic Research in Cardiology.

[62]  L. Weinstein,et al.  Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting. , 2001, Endocrine reviews.

[63]  W. Sadee,et al.  Genetic variations in human G protein-coupled receptors: Implications for drug therapy , 2001, AAPS PharmSci.

[64]  S. Mundell,et al.  Rapid Agonist-induced Desensitization and Internalization of the A2B Adenosine Receptor Is Mediated by a Serine Residue Close to the COOH Terminus* , 2001, The Journal of Biological Chemistry.

[65]  Lakshmi A. Devi,et al.  G protein coupled receptor dimerization: implications in modulating receptor function , 2001, Journal of Molecular Medicine.

[66]  H. Jüppner,et al.  Paternal uniparental isodisomy of chromosome 20q--and the resulting changes in GNAS1 methylation--as a plausible cause of pseudohypoparathyroidism. , 2001, American journal of human genetics.

[67]  D. Bonthron,et al.  Imprinting of the Gsα gene GNAS1 in the pathogenesis of acromegaly , 2001 .

[68]  G. Mcallister,et al.  Orphan G-protein-coupled receptors and natural ligand discovery. , 2001, Trends in pharmacological sciences.

[69]  M. Levine,et al.  Selective resistance to parathyroid hormone caused by a novel uncoupling mutation in the carboxyl terminus of G alpha(s). A cause of pseudohypoparathyroidism type Ib. , 2001, The Journal of biological chemistry.

[70]  G. Rousseau,et al.  The palmitoylation state of the β2‐adrenergic receptor regulates the synergistic action of cyclic AMP‐dependent protein kinase and β‐adrenergic receptor kinase involved in its phosphorylation and desensitization , 2001, Journal of neurochemistry.

[71]  L. Ma,et al.  Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation. , 2000, Molecular pharmacology.

[72]  B. J. Knoll,et al.  Localization of the sites mediating desensitization of the beta(2)-adrenergic receptor by the GRK pathway. , 2000, Molecular pharmacology.

[73]  T. Dryja Molecular genetics of Oguchi disease, fundus albipunctatus, and other forms of stationary night blindness: LVII Edward Jackson Memorial Lecture. , 2000, American journal of ophthalmology.

[74]  M. Ascoli,et al.  Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor. , 2000, Molecular endocrinology.

[75]  Jilly F. Evans,et al.  Characterization of the Human Cysteinyl Leukotriene 2 Receptor* , 2000, The Journal of Biological Chemistry.

[76]  H. Lother,et al.  AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration , 2000, Nature.

[77]  K. Palczewski,et al.  Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor , 2002, Chembiochem : a European journal of chemical biology.

[78]  D. Massotte,et al.  Internalization and recycling of delta-opioid receptor are dependent on a phosphorylation-dephosphorylation mechanism. , 2000, The Journal of pharmacology and experimental therapeutics.

[79]  V. Gurevich,et al.  Arrestin Binding to the M2 Muscarinic Acetylcholine Receptor Is Precluded by an Inhibitory Element in the Third Intracellular Loop of the Receptor* , 2000, The Journal of Biological Chemistry.

[80]  T. Palmer,et al.  Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor. , 2000, Molecular pharmacology.

[81]  B. O'dowd,et al.  Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor. , 1999, European journal of pharmacology.

[82]  M. Lidow,et al.  N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells. , 1999, Molecular pharmacology.

[83]  C. Créminon,et al.  Role of the carboxyl‐terminal region, di‐leucine motif and cysteine residues in signalling and internalization of vasopressin V1a receptor , 1999, FEBS letters.

[84]  E. Prossnitz,et al.  Differential Phosphorylation Paradigms Dictate Desensitization and Internalization of the N-Formyl Peptide Receptor* , 1999, The Journal of Biological Chemistry.

[85]  D. Sibley,et al.  Regulation of D(1) dopamine receptors with mutations of protein kinase phosphorylation sites: attenuation of the rate of agonist-induced desensitization. , 1999, Molecular pharmacology.

[86]  C. K. Surratt,et al.  Mutation of human μ opioid receptor extracellular “disulfide cysteine” residues alters ligand binding but does not prevent receptor targeting to the cell plasma membrane , 1999 .

[87]  B. O'dowd,et al.  Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase. , 1999, The Journal of biological chemistry.

[88]  J. Wess,et al.  Identification and Molecular Characterization of m3 Muscarinic Receptor Dimers* , 1999, The Journal of Biological Chemistry.

[89]  Jilly F. Evans,et al.  Characterization of the human cysteinyl leukotriene CysLT1 receptor , 1999, Nature.

[90]  W. Müller-Esterl,et al.  Bradykinin-induced Internalization of the Human B2Receptor Requires Phosphorylation of Three Serine and Two Threonine Residues at Its Carboxyl Tail* , 1999, The Journal of Biological Chemistry.

[91]  Cori Bargmann Neurobiology of the Caenorhabditis elegans genome. , 1998, Science.

[92]  J. Chambers,et al.  Orphan G‐protein‐coupled receptors: the next generation of drug targets? , 1998, British journal of pharmacology.

[93]  P. Seeman,et al.  A Transmembrane Domain-derived Peptide Inhibits D1 Dopamine Receptor Function without Affecting Receptor Oligomerization* , 1998, The Journal of Biological Chemistry.

[94]  Robert J. Lefkowitz,et al.  G Protein-coupled Receptors , 1998, The Journal of Biological Chemistry.

[95]  D. Accili,et al.  Variable and tissue-specific hormone resistance in heterotrimeric Gs protein α-subunit (Gsα) knockout mice is due to tissue-specific imprinting of the Gsα gene , 1998 .

[96]  R. Mailman,et al.  Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. , 1998, The Journal of pharmacology and experimental therapeutics.

[97]  J. Friedman,et al.  Desensitization of β2-Adrenergic Receptors with Mutations of the Proposed G Protein-coupled Receptor Kinase Phosphorylation Sites* , 1998, The Journal of Biological Chemistry.

[98]  T. Ogihara,et al.  Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension. , 1998, American journal of hypertension.

[99]  K. Kameyama,et al.  Internalization and Down-regulation of Human Muscarinic Acetylcholine Receptor m2 Subtypes , 1998, The Journal of Biological Chemistry.

[100]  S. Carr,et al.  Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior , 1998, Cell.

[101]  D. Proud,et al.  Influence of the Cytosolic Carboxyl Termini of Human B1 and B2 Kinin Receptors on Receptor Sequestration, Ligand Internalization, and Signal Transduction* , 1998, The Journal of Biological Chemistry.

[102]  A. Cideciyan,et al.  Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[103]  M. Lohse,et al.  A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[104]  D. Diviani,et al.  Characterization of the Phosphorylation Sites Involved in G Protein-coupled Receptor Kinase- and Protein Kinase C-mediated Desensitization of the α1B-Adrenergic Receptor* , 1997, The Journal of Biological Chemistry.

[105]  D. Bergsma,et al.  Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery. , 1997, Trends in pharmacological sciences.

[106]  M. Landt,et al.  Calcium-stimulated Phosphorylation of MAP-2 in Pancreatic βTC3-cells Is Mediated by Ca2+/Calmodulin-dependent Kinase II* , 1997, The Journal of Biological Chemistry.

[107]  B. O'dowd,et al.  Agonist-induced Desensitization of the μ Opioid Receptor Is Determined by Threonine 394 Preceded by Acidic Amino Acids in the COOH-terminal Tail* , 1997, The Journal of Biological Chemistry.

[108]  W. Meyerhof,et al.  Phosphorylation of Four Amino Acid Residues in the Carboxyl Terminus of the Rat Somatostatin Receptor Subtype 3 Is Crucial for Its Desensitization and Internalization* , 1997, The Journal of Biological Chemistry.

[109]  Gebhard F. X. Schertler,et al.  Arrangement of rhodopsin transmembrane α-helices , 1997, Nature.

[110]  J. Edwardson,et al.  Endocytosis and recycling of G protein-coupled receptors. , 1997, Trends in pharmacological sciences.

[111]  R. Pals-Rylaarsdam,et al.  Two Homologous Phosphorylation Domains Differentially Contribute to Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor* , 1997, The Journal of Biological Chemistry.

[112]  B. O'dowd,et al.  Elimination of palmitoylation sites in the human dopamine D1 receptor does not affect receptor-G protein interaction. , 1997, European journal of pharmacology.

[113]  T. Palmer,et al.  Identification of an A2a adenosine receptor domain specifically responsible for mediating short-term desensitization. , 1997, Biochemistry.

[114]  Julie A. Pitcher,et al.  The Role of Sequestration in G Protein-coupled Receptor Resensitization , 1997, The Journal of Biological Chemistry.

[115]  C. Romano,et al.  Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer* , 1996, The Journal of Biological Chemistry.

[116]  H. Heng,et al.  A novel gene codes for a putative G protein‐coupled receptor with an abundant expression in brain , 1996, FEBS letters.

[117]  R. Stoffel,et al.  Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES* , 1996, The Journal of Biological Chemistry.

[118]  J. Benovic,et al.  β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor , 1996, Nature.

[119]  M. Caron,et al.  G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins , 1996 .

[120]  L. Miller,et al.  Role of Receptor Phosphorylation in Desensitization and Internalization of the Secretin Receptor* , 1996, The Journal of Biological Chemistry.

[121]  M. Drazner,et al.  Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[122]  B Rosner,et al.  The relationship between visual field size and electroretinogram amplitude in retinitis pigmentosa. , 1996, Investigative ophthalmology & visual science.

[123]  R. Lefkowitz,et al.  Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor* , 1996, The Journal of Biological Chemistry.

[124]  S. R. Nash,et al.  Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases (*) , 1996, The Journal of Biological Chemistry.

[125]  M. Caron,et al.  Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization , 1996, Science.

[126]  T. Palmer,et al.  Agonist-dependent Phosphorylation and Desensitization of the Rat A3 Adenosine Receptor , 1995, The Journal of Biological Chemistry.

[127]  J. Benovic,et al.  Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms * , 1995, The Journal of Biological Chemistry.

[128]  C. Kunsch,et al.  Isolation of cDNA Clones Encoding Eight Different Human G Protein γ Subunits, Including Three Novel Forms Designated the γ4, γ10, and γ11 Subunits (*) , 1995, The Journal of Biological Chemistry.

[129]  K. Palczewski,et al.  Mechanism of rhodopsin phosphorylation. , 1995, Biophysical chemistry.

[130]  A. Shenker,et al.  G protein-coupled receptor structure and function: the impact of disease-causing mutations. , 1995, Bailliere's clinical endocrinology and metabolism.

[131]  K. Palczewski,et al.  Rhodopsin Kinase Autophosphorylation , 1995, The Journal of Biological Chemistry.

[132]  A. Milam,et al.  Rhodopsin Phosphorylation and Dephosphorylation in Vivo(*) , 1995, The Journal of Biological Chemistry.

[133]  M. Lohse,et al.  Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization. , 1995, Molecular pharmacology.

[134]  S. Schmid,et al.  Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals , 1995, Nature.

[135]  S. Schmid,et al.  Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding , 1995, Nature.

[136]  S. Liggett,et al.  Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor (*) , 1995, The Journal of Biological Chemistry.

[137]  M. Lohse,et al.  The role of G-protein beta gamma subunits in signal transduction. , 1995, Biochemical Society transactions.

[138]  James Inglese,et al.  Protein kinases that phosphorylate activated G protein‐coupled receptors , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[139]  C. Malbon,et al.  Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[140]  P Ducimetière,et al.  Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction , 1994, The Lancet.

[141]  J. Benovic,et al.  Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. , 1994, The Journal of biological chemistry.

[142]  L. Weinstein,et al.  An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome. , 1994, The Journal of clinical endocrinology and metabolism.

[143]  A. Gilman,et al.  G protein βγ subunits: Simplified purification and properties of novel isoforms , 1994 .

[144]  T. K. Harden,et al.  Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits. , 1994, The Journal of biological chemistry.

[145]  M. Caron,et al.  A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. , 1994, The Journal of biological chemistry.

[146]  R. Lefkowitz,et al.  Structure and mechanism of the G protein-coupled receptor kinases. , 1993, The Journal of biological chemistry.

[147]  M. Lohse,et al.  Molecular mechanisms of membrane receptor desensitization. , 1993, Biochimica et biophysica acta.

[148]  R. Jensen,et al.  Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization. , 1993, The Journal of biological chemistry.

[149]  D. Segaloff,et al.  Disruption of potential sites for N-linked glycosylation does not impair hormone binding to the lutropin/choriogonadotropin receptor if Asn-173 is left intact. , 1993, The Journal of biological chemistry.

[150]  S. Schmid The mechanism of receptor‐mediated endocytosis: More questions than answers , 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

[151]  L. Stryer,et al.  The target sets the tempo , 1992, Nature.

[152]  C. Fraser,et al.  Site-directed mutagenesis of the rat m1 muscarinic acetylcholine receptor. Role of conserved cysteines in receptor function. , 1992, The Journal of biological chemistry.

[153]  A. Gilman,et al.  Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. , 1991, Science.

[154]  E. Krebs,et al.  Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. , 1991, The Journal of biological chemistry.

[155]  M. Caron,et al.  Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[156]  M. Caron,et al.  Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. , 1991, Biochemistry.

[157]  M. Caron,et al.  A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[158]  G Vassart,et al.  Current developments in G-protein-coupled receptors. , 1991, Current opinion in cell biology.

[159]  E. Gershon,et al.  Genetic mapping of the Gs-alpha subunit gene (GNAS1) to the distal long arm of chromosome 20 using a polymorphism detected by denaturing gradient gel electrophoresis. , 1991, Genomics.

[160]  A. Spiegel,et al.  Albright's hereditary osteodystrophy and defective G proteins. , 1990, The New England journal of medicine.

[161]  R. Iyengar,et al.  Distinct guanine nucleotide binding and release properties of the three Gi proteins. , 1990, The Journal of biological chemistry.

[162]  M. Caron,et al.  Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. , 1990, The Journal of biological chemistry.

[163]  M. Caron,et al.  Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. , 1989, The Journal of biological chemistry.

[164]  H. Khorana,et al.  Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[165]  M. Caron,et al.  Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization , 1988, Nature.

[166]  A. S. Bogachuk,et al.  Two adjacent cysteine residues in the C‐terminal cytoplasmic fragment of bovine rhodopsin are palmitylated , 1988, FEBS letters.

[167]  D. Clapham,et al.  The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart , 1987, Nature.

[168]  C. Londos,et al.  A highly sensitive adenylate cyclase assay. , 1974, Analytical biochemistry.

[169]  B. Stricker,et al.  Interactions between five candidate genes and antihypertensive drug therapy on blood pressure , 2006, The Pharmacogenomics Journal.

[170]  T. Hansen,et al.  Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes , 2005, Diabetologia.

[171]  H. Jüppner,et al.  Deletion of the NESP55 differentially methylated region causes loss of maternal GNAS imprints and pseudohypoparathyroidism type Ib , 2005, Nature Genetics.

[172]  S. Ryu,et al.  Association between a G-protein β3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders , 2004, The Pharmacogenomics Journal.

[173]  Shihori Tanabe,et al.  Regulation of RGS-RhoGEFs by Gα12 and Gα13 Proteins , 2004 .

[174]  P. Chidiac,et al.  Activity, regulation, and intracellular localization of RGS proteins. , 2003, Receptors & channels.

[175]  T. Hébert,et al.  Protein complexes involved in heptahelical receptor-mediated signal transduction. , 2003, Receptors & channels.

[176]  J. Fernández-Real,et al.  G Protein β3 Gene Variant, Vascular Function, and Insulin Sensitivity in Type 2 Diabetes , 2003 .

[177]  P. Insel,et al.  Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications. , 2001, Annual review of pharmacology and toxicology.

[178]  C. Austin,et al.  Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. , 2001, American journal of respiratory and critical care medicine.

[179]  M. Farquhar,et al.  The regulator of G protein signaling family. , 2000, Annual review of pharmacology and toxicology.

[180]  R. Lefkowitz,et al.  G protein-coupled receptor kinases. , 1998, Annual review of biochemistry.

[181]  J. Benovic,et al.  The role of receptor kinases and arrestins in G protein-coupled receptor regulation. , 1998, Annual review of pharmacology and toxicology.

[182]  Arya M. Sharma,et al.  Association of a human G-protein β3 subunit variant with hypertension , 1998, Nature Genetics.

[183]  F. Monsma,et al.  Orphan receptors and their natural ligands. , 1997, Journal of receptor and signal transduction research.

[184]  R. Lefkowitz,et al.  Desensitization of G protein-coupled receptors. , 1996, Recent progress in hormone research.

[185]  R. Sunahara,et al.  Complexity and diversity of mammalian adenylyl cyclases. , 1996, Annual review of pharmacology and toxicology.

[186]  A. Spiegel,et al.  Defects in G protein-coupled signal transduction in human disease. , 1996, Annual review of physiology.

[187]  C. Strader,et al.  Structure and function of G protein-coupled receptors. , 1994, Annual review of biochemistry.

[188]  H. G. Khorana,et al.  Palmitoylation of bovine opsin and its cysteine mutants in COS cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[189]  S. Trumpp-Kallmeyer,et al.  This is not a G protein-coupled receptor. , 1993, Trends in pharmacological sciences.

[190]  J. Thorner,et al.  Model systems for the study of seven-transmembrane-segment receptors. , 1991, Annual review of biochemistry.