Urinary leukotriene E4 in Henoch–Schonlein purpura

Background Children with Henoch–Schonlein purpura (HSP) occasionally have allergic disease. We have previously shown that pranlukast hydrate was effective for purpura in HSP. Pranlukast hydrate is a leukotriene (LT) receptor antagonist; therefore, it is likely that LTs take part in the cause of HSP. Urinary leukotriene E4 (LTE4u) levels are a useful index of whole‐body cysteinyl LT production in vivo. In this study, LTE4u was examined in children with HSP.

[1]  J. Nagy,et al.  Possible pathogenic role of IgE in Henoch-Schönlein purpura , 1994, Pediatric Nephrology.

[2]  U. Wahn,et al.  Urinary leukotriene E4 levels in children with allergic rhinitis treated with specific immunotherapy and anti‐IgE (Omalizumab) , 2003, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[3]  M. Fujita,et al.  Preclinical pharmacology of pranlukast , 2001 .

[4]  G. Wennergren.  Inflammatory mediators in blood and urine. , 2000, Paediatric respiratory reviews.

[5]  M. Kumlin.  Measurement of leukotrienes in humans. , 2000, American journal of respiratory and critical care medicine.

[6]  M. Kumlin,et al.  Urinary excretion of inflammatory mediators during allergen‐induced early and late phase asthmatic reactions , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  糾 酒井,et al.  ヘノッホ－シェーンライン紫斑病の紫斑に対するpranlukast hydrateの有用性について , 1998 .

[8]  M. Kumlin.  Measurements of leukotrienes in the urine: strategies and applications , 1997, Allergy.

[9]  W. Wilmanns,et al.  Cysteinyl leukotriene production in anaphylactic reactions. , 1995, International archives of allergy and immunology.

[10]  H. Aishita,et al.  In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues. , 1992, Japanese journal of pharmacology.

[11]  K. Sinha,et al.  Schönlein-Henoch Syndrome After Insect Bite , 1966, British medical journal.

[12]  B. Jensen.  Schönlein-Henoch's purpura; three cases with fish or penicillin as antigen. , 2009, Acta medica Scandinavica.

[13]  H. Jellinek,et al.  Nearly fatal case of Schoenlein-Henoch syndrome following insect bite. , 1954, A.M.A. American journal of diseases of children.

[14]  J. Ackroyd.  Allergic purpura, including purpura due to foods, drugs and infections. , 1953, The American journal of medicine.