HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology

[1]  Lars K. Nielsen,et al.  Construction of feasible and accurate kinetic models of metabolism: A Bayesian approach , 2016, Scientific Reports.

[2]  Chris J. Myers,et al.  Toward community standards and software for whole-cell modeling , 2016, IEEE Transactions on Biomedical Engineering.

[3]  S. Bulik,et al.  The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism – insights from mathematical modeling , 2016, BMC Biology.

[4]  Hermann-Georg Holzhütter,et al.  Physiology-Based Kinetic Modeling of Neuronal Energy Metabolism Unravels the Molecular Basis of NAD(P)H Fluorescence Transients , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[5]  Branwen S Morgan,et al.  Fatty liver disease: The liver labyrinth , 2014, Nature.

[6]  Hyung-Ryong Kim,et al.  Soybean greatly reduces valproic acid plasma concentrations: A food–drug interaction study , 2014, Scientific Reports.

[7]  Zachary A. King,et al.  Constraint-based models predict metabolic and associated cellular functions , 2014, Nature Reviews Genetics.

[8]  D. W. Foster Malonyl-CoA: the regulator of fatty acid synthesis and oxidation. , 2012, The Journal of clinical investigation.

[9]  S. Bulik,et al.  Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism , 2012, PLoS Comput. Biol..

[10]  Karuna Rasineni,et al.  Molecular mechanism of alcoholic fatty liver , 2012, Indian journal of pharmacology.

[11]  J. Liao,et al.  Metabolic ensemble modeling for strain engineers , 2012, Biotechnology journal.

[12]  R. Deberardinis,et al.  Glutamine: pleiotropic roles in tumor growth and stress resistance , 2011, Journal of Molecular Medicine.

[13]  V. Olman,et al.  A Comparative Analysis of Gene-Expression Data of Multiple Cancer Types , 2010, PloS one.

[14]  I. T. de Almeida,et al.  Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. , 2010, Biochemical pharmacology.

[15]  L. Elsas,et al.  Galactose toxicity in animals , 2009, IUBMB life.

[16]  N. Anderson,et al.  Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis , 2008, Pharmacological Reviews.

[17]  A. Cornish-Bowden Putting the Systems Back into Systems Biology , 2006, Perspectives in biology and medicine.

[18]  Wei Sun,et al.  Proteomic analysis of individual variation in normal livers of human beings using difference gel electrophoresis , 2006, Proteomics.

[19]  D. Timson The structural and molecular biology of type III galactosemia , 2006, IUBMB life.

[20]  M. Bradbury Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[21]  S. Minucci,et al.  Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis , 2005, Cell.

[22]  Marc W Kirschner,et al.  The Meaning of Systems Biology , 2005, Cell.

[23]  T. Nikolaos,et al.  The effect of long-term antiepileptic treatment on serum cholesterol (TC, HDL, LDL) and triglyceride levels in adult epileptic patients on monotherapy. , 2004, Medical science monitor : international medical journal of experimental and clinical research.

[24]  F. Chiarelli,et al.  Valproate-Induced Hyperammonemic Encephalopathy , 2002, Metabolic Brain Disease.

[25]  D. Crabb,et al.  Ethanol Induces Fatty Acid Synthesis Pathways by Activation of Sterol Regulatory Element-binding Protein (SREBP)* , 2002, The Journal of Biological Chemistry.

[26]  R G Shulman,et al.  Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. , 1991, Science.

[27]  S. Eisenberg,et al.  Diurnal variations of plasma lipids, tissue and plasma lipoprotein lipase, and VLDL secretion rates in the rat. A model for studies of VLDL metabolism. , 1987, Biochimica et biophysica acta.

[28]  M. Hjelm,et al.  VALPROATE INHIBITION OF UREA SYNTHESIS , 1987, The Lancet.

[29]  Robert A. Harris,et al.  Influence of valproic acid on hepatic carbohydrate and lipid metabolism. , 1983, Archives of biochemistry and biophysics.

[30]  J. Volpe,et al.  Mechanisms and regulation of biosynthesis of saturated fatty acids. , 1976, Physiological reviews.

[31]  R Heinrich,et al.  The regulatory principles of glycolysis in erythrocytes in vivo and in vitro. A minimal comprehensive model describing steady states, quasi-steady states and time-dependent processes. , 1976, The Biochemical journal.

[32]  R. Veech,et al.  Ethanol administration and the relationship of malonyl-coenzyme A concentrations to the rate of fatty acid synthesis in rat liver. , 1973, The Biochemical journal.

[33]  J. Sebus,et al.  POTASSIUM DEPLETION AND CHRONIC PYELONEPHRITIS. , 1964, Lancet.

[34]  Nicolas Le Novère,et al.  BioModels Database: a repository of mathematical models of biological processes. , 2013, Methods in molecular biology.

[35]  Carel van Gend,et al.  Data and Model Integration Using JWS Online , 2007, Silico Biol..

[36]  A. Nanji,et al.  Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation. , 2004, The Journal of pharmacology and experimental therapeutics.

[37]  A. Nanji,et al.  ALCOHOLIC LIVER INJURY IN THE RAT IS ASSOCIATED WITH REDUCED EXPRESSION OF PEROXISOME PROLIFERATOR-ALPHA (PPAR α ) REGULATED GENES AND IS AMELIORATED BY PPAR α ACTIVATION , 2004 .

[38]  K. Alberti,et al.  Disturbances of metabolic homeostasis is liver disease. , 1981, Acta medica portuguesa.

[39]  B. Rosenfeld,et al.  Diurnal changes in liver and plasma lipids of choline-deficient rats. , 1966, Journal of lipid research.