Lidocaína com vasoconstrictor isolada e associada ao fentanil via peridural em cães

The objective of this blind study was to investigate the cardiopulmonary and analgesic effects of different doses of fentanyl combined with lidocaine by epidural route in dogs. Twenty-eight dogs were distributed in four treatments: 5mg kg-1 of lidocaine with vasoconstrictor alone (L) and in combination with 2.5, 5 e 7mg kg-1 of fentanyl (F2.5, F5 e F7). The preanaesthetic medication was intravenous acepromazine (0.05mg kg-1). An intravenous bolus of fentanyl (2.5mg kg-1) was administered immediately before epidural injection. Heart and respiratory rates, electrocardiography, systolic arterial blood pressure, rectal temperature, arterial blood gases, onset time, duration of anesthesia and sensitive block level were investigated. There was decrease of heart rate after epidural injection when compared with the baseline values in F2.5, F5 and F7 treatments. Heart rate was higher in L when compared with F5 and F7 at 30 and 60 minutes after epidural anesthesia. Onset time was not statically different among the treatments. Duration of anesthesia was longer in F5 when compared with the other treatments. Sensitive block until the sixth lumbar vertebra occurred in four dogs in L. Sensitive block until the first lumbar vertebra occurred in five dogs in F2.5 and F7 and in six dogs in F5. In conclusion, the addition of fentanyl to lidocaine in epidural anesthesia allowed cranial sensory block in relation to the isolated use of lidocaine. The addition of fentanyl (5mg kg-1) to lidocaine prolonged the anesthetic blockade when compared with others treatments.

[1]  R. N. Cassu,et al.  Anestesia epidural com lidocaína isolada e associada ao fentanil para realização de ováriossalpingo-histerectomia em cadelas , 2008 .

[2]  S. Hoka,et al.  Regression of sensory and motor blockade, and analgesia during continuous epidural infusion of ropivacaine and fentanyl in comparison with other local anesthetics. , 2007, Pain medicine.

[3]  B. M. Silva Avaliação cardiorrespiratória e analgésica da ropivacaína isolada e associada ao fentanil ou ao tramadol, administrados pela via peridural em cães , 2007 .

[4]  S. P. L. Luna,et al.  Anestesia epidural com ropivacaína, lidocaína ou associação de lidocaína e xilazina em cães: efeitos cardiorrespiratório e analgésico , 2007 .

[5]  M. Mochizuki,et al.  Pharmacokinetics of fentanyl after single intravenous injection and constant rate infusion in dogs. , 2006, Veterinary anaesthesia and analgesia.

[6]  Pedro Wanderley de Aragão,et al.  Bloqueio peridural sacral: avaliação da duração da analgesia com o uso associado de lidocaína, fentanil e clonidina , 2004 .

[7]  M. M. R. S. Martins,et al.  [Epidural caudal block: evaluation of length of analgesia with the association of lidocaine, fentanyl and clonidine.]. , 2004, Revista brasileira de anestesiologia.

[8]  Xin Wang,et al.  Fentanyl inhibits GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus , 2004, Brain Research.

[9]  N. Nunes,et al.  ELETROCARDIOGRAFIA DE CÃES SUBMETIDOS A DIFERENTES CONCENTRAÇÕES DE DESFLURANO, PRÉ-TRATADOS OU NÃO COM A ASSOCIAÇÃO DE FENTANIL/DROPERIDOL ELECTROCARDIOGRAPHY OF DOGS UNDERGOING DIFFERENT DESFLURANE CONCENTRATIONS, PREMEDICATED OR NOT WITH FENTANYL/DROPERIDOL ASSOCIATION , 2001 .

[10]  S. Luna,et al.  Epidural anaesthesia using lignocaine, bupivacaine or a mixture of lignocaine and bupivacaine in dogs , 1997 .

[11]  Shigehito Sato,et al.  The Comparison of Epidural Fentanyl, Epidural Lidocaine, and Intravenous Fentanyl in Patients Undergoing Gastrectomy , 1995, Anesthesia and analgesia.

[12]  P. Conlon,et al.  Cisternal CSF and serum concentrations of morphine following epidural administration in the dog. , 1992, Journal of veterinary pharmacology and therapeutics.

[13]  A. Mazzanti,et al.  Analgesia trans e pós-operatória da morfina ou fentanil por via epidural em cães submetidos à biópsia atlanto-axial , 2008 .

[14]  S. R. G. Cortopassi,et al.  Tranqüilizantes e sedativos , 2002 .

[15]  B. Aminkov COMPARISON BETWEEN LIDOCAINE ALONE AND FENTANYL WITH LIDOCAINE FOR EPIDURAL ANAESTHESIA IN DOGS , 1996 .

[16]  B. Covino,et al.  Local Anesthetics , 1987, Handbook of Experimental Pharmacology.

[17]  I. Nolte,et al.  Cardiovascular effects of epidural blocks in dogs , 1983 .