Effects of ultra-high dose rate FLASH irradiation on the tumor microenvironment in Lewis lung carcinoma: role of myosin light chain.

[1]  Amy S. Yu,et al.  Abstract 5351: FLASH irradiation enhances the therapeutic index of abdominal radiotherapy in mice , 2020 .

[2]  Lei Dong,et al.  Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System. , 2020, International journal of radiation oncology, biology, physics.

[3]  E. Hammond,et al.  Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold? , 2020, Frontiers in Oncology.

[4]  M. W. Lambert.  Cytoskeletal and nucleoskeletal interacting protein networks play critical roles in cellular function and dysfunction , 2019, Experimental biology and medicine.

[5]  J. Bourhis,et al.  Treatment of a first patient with FLASH-radiotherapy. , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[6]  J. Bourhis,et al.  Clinical translation of FLASH radiotherapy: Why and how? , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[7]  T. Kalin,et al.  Improved Tumor Control Through T-cell Infiltration Modulated by Ultra-High Dose Rate Proton FLASH Using a Clinical Pencil Beam Scanning Proton System , 2019, International Journal of Radiation Oncology*Biology*Physics.

[8]  C. Koch.  Re: Differential impact of FLASH versus conventional dose rate irradiation: Spitz et al. , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[9]  E. Choi,et al.  Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation , 2019, Cancers.

[10]  J. Hendry,et al.  Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken. , 2019, Clinical oncology (Royal College of Radiologists (Great Britain)).

[11]  Ž. Vujašković,et al.  Abstract LB-280: FLASH: A novel paradigm changing tumor irradiation platform that enhances therapeutic ratio by reducing normal tissue toxicity and activating immune pathways , 2019, Experimental and Molecular Therapeutics.

[12]  Danielle A. Simmons,et al.  Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation. , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[13]  Peter G Maxim,et al.  PHASER: A platform for clinical translation of FLASH cancer radiotherapy. , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[14]  S. Gasser,et al.  Nuclear Actin and Actin-Binding Proteins in DNA Repair. , 2019, Trends in cell biology.

[15]  J. Bourhis,et al.  Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species , 2019, Proceedings of the National Academy of Sciences.

[16]  T. Waldron,et al.  An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses. , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[17]  S. Zahler,et al.  Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy , 2019, Cell Death & Disease.

[18]  Min Young Yoo,et al.  Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis. , 2019, Cancer research.

[19]  J. Bourhis,et al.  X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice. , 2018, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[20]  J. Bourhis,et al.  The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients , 2018, Clinical Cancer Research.

[21]  Shaleen Kumar,et al.  Magnitude, Impact, and Management of Respiration-induced Target Motion in Radiotherapy Treatment: A Comprehensive Review , 2017, Journal of medical physics.

[22]  G. Cheon,et al.  Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization. , 2016, International journal of radiation oncology, biology, physics.

[23]  R. Weichselbaum,et al.  Nonmuscle Myosin Light Chain Kinase Activity Modulates Radiation-Induced Lung Injury , 2016, Pulmonary circulation.

[24]  Christopher A. Lemmon,et al.  Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension. , 2016, Biophysical journal.

[25]  R. Mullins,et al.  DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair , 2015, eLife.

[26]  H. Sandler,et al.  Stereotactic body radiation therapy: Let's not give up on progress. , 2015, Practical radiation oncology.

[27]  O. Desouky,et al.  Targeted and non-targeted effects of ionizing radiation , 2015 .

[28]  W. V. van IJcken,et al.  Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. , 2015, Blood.

[29]  Philippe Hupé,et al.  Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice , 2014, Science Translational Medicine.

[30]  Soumya Das.  Critical Review of Water Radiolysis Processes, Dissociation Products, and Possible Impacts on the Local Environment: A Geochemist , 2013 .

[31]  D. Gabrilovich,et al.  Molecular Pathways: Tumor-Infiltrating Myeloid Cells and Reactive Oxygen Species in Regulation of Tumor Microenvironment , 2012, Clinical Cancer Research.

[32]  S. Tyldesley,et al.  Estimating the need for radiotherapy for patients with prostate, breast, and lung cancers: verification of model estimates of need with radiotherapy utilization data from British Columbia. , 2011, International journal of radiation oncology, biology, physics.

[33]  D. Verellen,et al.  Innovations in image-guided radiotherapy , 2007, Nature Reviews Cancer.

[34]  N. Curtin,et al.  Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM , 2004, Cancer Research.

[35]  D. Rogers,et al.  AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams. , 1999, Medical physics.

[36]  D. Hartshorne,et al.  Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. , 1989, Biochemical and biophysical research communications.

[37]  B. Loo,et al.  Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator. , 2017, International journal of radiation oncology, biology, physics.

[38]  M. Kudo,et al.  p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. , 2013, Cancer research.

[39]  Linda J. Kuo,et al.  Gamma-H2AX - a novel biomarker for DNA double-strand breaks. , 2008, In vivo.

[40]  M. Ahmad,et al.  Molecular mechanisms of N-acetylcysteine actions , 2003, Cellular and Molecular Life Sciences CMLS.

[41]  Y Taya,et al.  Enhanced phosphorylation of p53 by ATM in response to DNA damage. , 1998, Science.

[42]  J. Spudich,et al.  Control of nonmuscle myosins by phosphorylation. , 1992, Annual review of biochemistry.