An Update on the Pharmacological Usage of Curcumin: Has it Failed in the Drug Discovery Pipeline?

[1]  R. Agrawal,et al.  Cellular and molecular mechanisms of curcumin in prevention and treatment of disease , 2020, Critical reviews in food science and nutrition.

[2]  Dapeng Li,et al.  Are we seeing a resurgence in the use of natural products for new drug discovery? , 2019, Expert opinion on drug discovery.

[3]  Akash K. George,et al.  Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke , 2019, Neurochemistry International.

[4]  Jianhui Xie,et al.  Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway , 2018, Front. Pharmacol..

[5]  A. Kunnumakkara,et al.  Development of Validated Methods and Quantification of Curcuminoids and Curcumin Metabolites and Their Pharmacokinetic Study of Oral Administration of Complete Natural Turmeric Formulation (Cureit™) in Human Plasma via UPLC/ESI-Q-TOF-MS Spectrometry , 2018, Molecules.

[6]  J. Wan,et al.  Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL‐4Rα‐Jak1‐STAT6 and Jagged1/Jagged2 ‐Notch1/Notch2 pathways in asthmatic mice , 2018, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  Changquan Calvin Sun,et al.  Cocrystallization of Curcumin with Benzenediols and Benzenetriols via Rapid Solvent Removal , 2018, Crystal Growth & Design.

[8]  Xinrong Liu,et al.  Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents , 2018, Asian journal of pharmaceutical sciences.

[9]  I. Kaur,et al.  Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation: in vitro and in vivo study , 2018, Drug development and industrial pharmacy.

[10]  Si-ying Zhou,et al.  Liposomal Curcumin Targeting Endometrial Cancer Through the NF-κB Pathway , 2018, Cellular Physiology and Biochemistry.

[11]  F. Abas,et al.  Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT) , 2018, BMC Complementary and Alternative Medicine.

[12]  R. Jamwal.  Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers. , 2018, Journal of integrative medicine.

[13]  M. Farzaei,et al.  Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective , 2018, Nutrients.

[14]  A. Nangia,et al.  Curcumin: pharmaceutical solids as a platform to improve solubility and bioavailability , 2018 .

[15]  Sabu Thomas,et al.  Preparation, characterization and in vitro study of liposomal curcumin powder by cost effective nanofiber weaving technology , 2018 .

[16]  N. Calcutt,et al.  A novel curcumin derivative for the treatment of diabetic neuropathy , 2018, Neuropharmacology.

[17]  Jianming Ju,et al.  Studies on the curcumin phospholipid complex solidified with Soluplus® , 2018, The Journal of pharmacy and pharmacology.

[18]  D. Zodda,et al.  Treatment Strategy for Dyslipidemia in Cardiovascular Disease Prevention: Focus on Old and New Drugs , 2018, Pharmacy.

[19]  M. Majeed,et al.  Subchronic and Reproductive/Developmental Toxicity Studies of Tetrahydrocurcumin in Rats , 2018, Toxicological research.

[20]  P. Maher,et al.  The mitochondrial ATP synthase is a shared drug target for aging and dementia , 2018, Aging cell.

[21]  S. Stohs,et al.  A Comparative Pharmacokinetic Assessment of a Novel Highly Bioavailable Curcumin Formulation with 95% Curcumin: A Randomized, Double-Blind, Crossover Study , 2018, Journal of the American College of Nutrition.

[22]  A. Goel,et al.  The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern? , 2017, Journal of restorative medicine.

[23]  D. Kalman,et al.  Curcumin: A Review of Its’ Effects on Human Health , 2017, Foods.

[24]  M. Roberts,et al.  Topical Nano and Microemulsions for Skin Delivery , 2017, Pharmaceutics.

[25]  M. Sancar,et al.  Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats. , 2017, Environmental toxicology and pharmacology.

[26]  A. Akbarzadeh,et al.  The Effects of Nanoencapsulated Curcumin-Fe3O4 on Proliferation and hTERT Gene Expression in Lung Cancer Cells. , 2017, Anti-cancer agents in medicinal chemistry.

[27]  Robert J. Lee,et al.  Liposomal curcumin and its application in cancer , 2017, International journal of nanomedicine.

[28]  A. Boddy,et al.  Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions , 2017, Expert opinion on drug metabolism & toxicology.

[29]  Shahid-ul-Islam,et al.  Curcumin and Its Derivatives – Isolation, Synthesis, and Applications , 2017 .

[30]  N. Sharma,et al.  Nanoformulations of curcumin: an emerging paradigm for improved remedial application , 2017, Oncotarget.

[31]  Sahdeo Prasad,et al.  Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases , 2017, British journal of pharmacology.

[32]  Liqiang Zou,et al.  Improved bioavailability of curcumin in liposomes prepared using a pH-driven, organic solvent-free, easily scalable process , 2017 .

[33]  N. Sanlier,et al.  Curcumin, an active component of turmeric (Curcuma longa), and its effects on health , 2017, Critical reviews in food science and nutrition.

[34]  P. Sil,et al.  New insights into the ameliorative effects of ferulic acid in pathophysiological conditions. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[35]  L. Huminiecki,et al.  The functional genomic studies of curcumin. , 2017, Seminars in cancer biology.

[36]  G. Münch,et al.  Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects , 2017, European Journal of Nutrition.

[37]  Jayme L. Dahlin,et al.  The Essential Medicinal Chemistry of Curcumin , 2017, Journal of medicinal chemistry.

[38]  J. Meins,et al.  Transepithelial Transport of Curcumin in Caco-2 Cells Is significantly Enhanced by Micellar Solubilisation , 2016, Plant Foods for Human Nutrition.

[39]  E. Sousa,et al.  Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives , 2016, Pharmaceuticals.

[40]  Marisa P. Sárria,et al.  Curcumin Encapsulated into Methoxy Poly(Ethylene Glycol) Poly(ε-Caprolactone) Nanoparticles Increases Cellular Uptake and Neuroprotective Effect in Glioma Cells , 2016, Planta Medica.

[41]  Chunyan Dong,et al.  Novel curcumin-loaded human serum albumin nanoparticles surface functionalized with folate: characterization and in vitro/vivo evaluation , 2016, Drug design, development and therapy.

[42]  Jing Xie,et al.  Nanotechnology for the delivery of phytochemicals in cancer therapy. , 2016, Biotechnology advances.

[43]  E. Hattingen,et al.  Intratumoral Concentrations and Effects of Orally Administered Micellar Curcuminoids in Glioblastoma Patients , 2016, Nutrition and cancer.

[44]  S. Gopi,et al.  Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review , 2016, Journal of traditional and complementary medicine.

[45]  J. Espinoza,et al.  Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence , 2016, Oncotarget.

[46]  Alpana Ankush Thorat,et al.  Ultrasound-assisted modulation of concomitant polymorphism of curcumin during liquid antisolvent precipitation. , 2016, Ultrasonics sonochemistry.

[47]  E. Skrzypczak‐Jankun,et al.  Determining whether curcumin degradation/condensation is actually bioactivation (Review). , 2016, International journal of molecular medicine.

[48]  G. Zhai,et al.  Oral bioavailability of curcumin: problems and advancements , 2016, Journal of drug targeting.

[49]  M. Ardjmand,et al.  Sustained release Curcumin loaded Solid Lipid Nanoparticles , 2016, Advanced pharmaceutical bulletin.

[50]  M. Ramirez-Tortosa,et al.  Curcumin and Health , 2016, Molecules.

[51]  U. Holzgrabe,et al.  Focus on PAINS: false friends in the quest for selective anti-protozoal lead structures from Nature? , 2016 .

[52]  Nannan Zheng,et al.  Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin , 2016, Drug delivery.

[53]  Pornsiri Pitchakarn,et al.  Chemosensitizing effects of synthetic curcumin analogs on human multi-drug resistance leukemic cells. , 2016, Chemico-biological interactions.

[54]  M. Majeed,et al.  Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites , 2015, Antioxidants.

[55]  H. Lou,et al.  Synthesis and Biological Evaluation of Curcumin Derivatives with Water-Soluble Groups as Potential Antitumor Agents: An in Vitro Investigation Using Tumor Cell Lines , 2015, Molecules.

[56]  D. Yanagisawa,et al.  Novel curcumin derivatives as potent inhibitors of amyloid β aggregation , 2015, Biochemistry and biophysics reports.

[57]  J. Frank,et al.  Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice – Impact on bioavailability , 2015, Neurochemistry International.

[58]  J. Irwin,et al.  An Aggregation Advisor for Ligand Discovery. , 2015, Journal of medicinal chemistry.

[59]  Å. Rasmuson,et al.  Solubility and crystal nucleation in organic solvents of two polymorphs of curcumin. , 2015, Journal of pharmaceutical sciences.

[60]  D. Nagesha,et al.  Polymeric Micelles as Novel Carriers for Poorly Soluble Drugs--A Review. , 2015, Journal of nanoscience and nanotechnology.

[61]  Luigi Gori,et al.  Curcumin, a golden spice with a low bioavailability , 2015 .

[62]  F. Gomez-Pinilla,et al.  Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. , 2015, Biochimica et biophysica acta.

[63]  Q. Jiang,et al.  Syntheses and characterizations of two curcumin-based cocrystals , 2015 .

[64]  B. Shoichet,et al.  Colloidal aggregation and the in vitro activity of traditional Chinese medicines. , 2015, ACS chemical biology.

[65]  D. Clouatre,et al.  Beyond Yellow Curry: Assessing Commercial Curcumin Absorption Technologies , 2015, Journal of the American College of Nutrition.

[66]  P. B. Luis,et al.  Degradation of Curcumin: From Mechanism to Biological Implications. , 2015, Journal of agricultural and food chemistry.

[67]  C. Groden,et al.  Value of Dynamic Susceptibility Contrast Perfusion MRI in the Acute Phase of Transient Global Amnesia , 2015, PloS one.

[68]  G. Rimbach,et al.  Thermal stability, antioxidant, and anti-inflammatory activity of curcumin and its degradation product 4-vinyl guaiacol. , 2015, Food & function.

[69]  Prakash Ramalingam,et al.  Enhanced Oral Delivery of Curcumin from N-trimethyl Chitosan Surface-Modified Solid Lipid Nanoparticles: Pharmacokinetic and Brain Distribution Evaluations , 2015, Pharmaceutical Research.

[70]  B. Aggarwal,et al.  Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses , 2014, Molecules.

[71]  K. Priyadarsini.  The Chemistry of Curcumin: From Extraction to Therapeutic Agent , 2014, Molecules.

[72]  B. Aggarwal,et al.  Curcumin, a component of golden spice: from bedside to bench and back. , 2014, Biotechnology advances.

[73]  Changquan Calvin Sun,et al.  Kinetic Entrapment of a Hidden Curcumin Cocrystal with Phloroglucinol , 2014 .

[74]  Ajazuddin,et al.  Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients. , 2014, Fitoterapia.

[75]  I. Baburin,et al.  Natural Products as Potential Human Ether-a-Go-Go-Related Gene Channel Inhibitors – Outcomes from a Screening of Widely Used Herbal Medicines and Edible Plants , 2014, Planta Medica.

[76]  J. Panyam,et al.  Co-delivery of natural metabolic inhibitors in a self-microemulsifying drug delivery system for improved oral bioavailability of curcumin , 2014, Drug Delivery and Translational Research.

[77]  Chuang Yang,et al.  Liposomal delivery and polyethylene glycol-liposomal oxaliplatin for the treatment of colorectal cancer (Review) , 2014, Biomedical reports.

[78]  J. Frank,et al.  The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. , 2014, Molecular nutrition & food research.

[79]  K. Pallauf,et al.  Curcumin may impair iron status when fed to mice for six months , 2014, Redox biology.

[80]  Zhongfa Liu,et al.  A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry. , 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[81]  Jacob M. Wilson,et al.  Comparative absorption of curcumin formulations , 2014, Nutrition Journal.

[82]  M. Broekgaarden,et al.  The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer , 2014, Pharmacological Reviews.

[83]  B. Aggarwal,et al.  Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice , 2014, Cancer research and treatment : official journal of Korean Cancer Association.

[84]  Yunliang Wang,et al.  Amelioration of β-amyloid-induced cognitive dysfunction and hippocampal axon degeneration by curcumin is associated with suppression of CRMP-2 hyperphosphorylation , 2013, Neuroscience Letters.

[85]  Subhashini,et al.  Intranasal curcumin and its evaluation in murine model of asthma. , 2013, International immunopharmacology.

[86]  G. Reddy,et al.  Curcumin Attenuation of Lipopolysaccharide Induced Cardiac Hypertrophy in Rodents , 2013, ISRN inflammation.

[87]  Romy K. Scheerle,et al.  Metabolism and permeability of curcumin in cultured Caco-2 cells. , 2013, Molecular nutrition & food research.

[88]  Maria Nowakowska,et al.  Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives. , 2013, Colloids and surfaces. B, Biointerfaces.

[89]  Kinam Park,et al.  Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs. , 2013, International journal of pharmaceutics.

[90]  F. Sarkar,et al.  Difluorinated-Curcumin (CDF) Restores PTEN Expression in Colon Cancer Cells by Down-Regulating miR-21 , 2013, PloS one.

[91]  Y. Makino,et al.  Novel curcumin oral delivery systems. , 2013, Anticancer research.

[92]  R. Mason,et al.  Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century , 2013, Current neuropharmacology.

[93]  V. Bagnato,et al.  Curcumin-mediated photodynamic inactivation of Candida albicans in a murine model of oral candidiasis. , 2013, Medical mycology.

[94]  D. Greenblatt,et al.  Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers , 2013, British journal of clinical pharmacology.

[95]  P. M. Abraham,et al.  Temperature-dependent spectroscopic evidences of curcumin in aqueous medium: a mechanistic study of its solubility and stability. , 2012, The journal of physical chemistry. B.

[96]  G. Zhai,et al.  Formulation and evaluation of microemulsion-based in situ ion-sensitive gelling systems for intranasal administration of curcumin , 2012, Journal of drug targeting.

[97]  R. Manavalan,et al.  Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles. , 2012, Asian Pacific journal of tropical biomedicine.

[98]  Catherine A. Sugar,et al.  Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study , 2012, Alzheimer's Research & Therapy.

[99]  C. Mohanty,et al.  Antiglioma activity of curcumin-loaded lipid nanoparticles and its enhanced bioavailability in brain tissue for effective glioblastoma therapy. , 2012, Acta biomaterialia.

[100]  K. Maeda,et al.  Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP , 2012, British journal of pharmacology.

[101]  J. Sugawara,et al.  Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study. , 2012, American journal of hypertension.

[102]  G. Zhai,et al.  N-trimethyl chitosan chloride-coated liposomes for the oral delivery of curcumin , 2012, Journal of liposome research.

[103]  U. Kukongviriyapan,et al.  Tetrahydrocurcumin alleviates hypertension, aortic stiffening and oxidative stress in rats with nitric oxide deficiency , 2012, Hypertension Research.

[104]  J. Deshpande,et al.  Evaluation of Antidepressant-Like Activity of Novel Water-Soluble Curcumin Formulations and St. John's Wort in Behavioral Paradigms of Despair , 2012, Pharmacology.

[105]  Q. Zhang,et al.  Curcumin inhibits hERG potassium channels in vitro. , 2012, Toxicology letters.

[106]  K. Abel,et al.  Evaluation in vitro of synthetic curcumins as agents promoting monocytic gene expression related to β-amyloid clearance. , 2012, Chemical research in toxicology.

[107]  S. Nair,et al.  Curcumin loaded chitin nanogels for skin cancer treatment via the transdermal route. , 2012, Nanoscale.

[108]  P. López‐Jornet,et al.  Topical curcumin for the healing of carbon dioxide laser skin wounds in mice. , 2011, Photomedicine and laser surgery.

[109]  Carol Imbriano,et al.  Newly synthesized curcumin derivatives: crosstalk between chemico-physical properties and biological activity. , 2011, Journal of medicinal chemistry.

[110]  Timothy C Wang,et al.  Curcumin Induces the Differentiation of Myeloid-Derived Suppressor Cells and Inhibits Their Interaction with Cancer Cells and Related Tumor Growth , 2011, Cancer Prevention Research.

[111]  C. Sadasivan,et al.  Molecular docking studies of curcumin analogs with phospholipase A2 , 2011, Interdisciplinary Sciences: Computational Life Sciences.

[112]  N. Rajesh Goud,et al.  Fast Dissolving Curcumin Cocrystals , 2011 .

[113]  Se-Woong Oh,et al.  Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition. , 2011, Journal of ethnopharmacology.

[114]  B. Aggarwal,et al.  Chemical Composition and Product Quality Control of Turmeric (Curcuma longa L.) , 2011 .

[115]  J. Panyam,et al.  Highly loaded, sustained-release microparticles of curcumin for chemoprevention. , 2011, Journal of pharmaceutical sciences.

[116]  F. Aqil,et al.  Advanced Drug Delivery Systems of Curcumin for Cancer Chemoprevention , 2011, Cancer Prevention Research.

[117]  M. Fujita,et al.  Innovative preparation of curcumin for improved oral bioavailability. , 2011, Biological & pharmaceutical bulletin.

[118]  Xia Zhao,et al.  Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. , 2011, Nanoscale.

[119]  K. Tomita-Yokotani,et al.  Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism , 2011, Proceedings of the National Academy of Sciences.

[120]  G. Appendino,et al.  Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. , 2011, Journal of natural products.

[121]  R. Benya,et al.  Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia , 2011, Cancer Prevention Research.

[122]  P. Chintana.  Downregulation of p-ERK1/2 and p-AKT expression by curcumin and tetrahydrocurcumin in hepatocellular carcinoma-induced tumors in nude mic , 2011 .

[123]  A. Bansal,et al.  Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[124]  Xiaoyuan Chen,et al.  Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity. , 2011, International journal of pharmaceutics.

[125]  T. Kálai,et al.  Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties , 2010, Cancer biology & therapy.

[126]  Kenneth K. Chan,et al.  A liquid chromatography-tandem mass spectrometric method for quantification of curcuminoids in cell medium and mouse plasma. , 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[127]  J. Leroux,et al.  Polymeric micelles for oral drug delivery. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[128]  M. Jaggi,et al.  beta-Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells. , 2010, Colloids and surfaces. B, Biointerfaces.

[129]  Noor Shahina Begum,et al.  Molecular Docking Studies of Curcumin Derivatives with Multiple Protein Targets for Procarcinogen Activating Enzyme Inhibition , 2010 .

[130]  J. Panyam,et al.  Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. , 2010, Cancer research.

[131]  N. Piyapolrungroj,et al.  Effects of Curcuma spp. on P-glycoprotein function. , 2010, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[132]  K. Srinivasan,et al.  Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. , 2010, The Indian journal of medical research.

[133]  M. Másson,et al.  Studies of curcumin and curcuminoids. XXXVI. The stoichiometry and complexation constants of cyclodextrin complexes as determined by the phase-solubility method and UV–Vis titration , 2010 .

[134]  G. Maru,et al.  Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. , 2010, Journal of agricultural and food chemistry.

[135]  K. Priyadarsini.  Photophysics, Photochemistry and Photobiology of Curcumin: Studies from Organic Solutions, Biomimetics and Living Cells , 2009 .

[136]  V. Basile,et al.  Curcumin derivatives: molecular basis of their anti-cancer activity. , 2009, Biochemical pharmacology.

[137]  M. R. Kumar,et al.  Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. , 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[138]  K. Priyadarsini.  Photophysics, photochemistry and photobiology of curcumin : Studies from organic solutions, bio-mimetics and living cells , 2009 .

[139]  Sanjeev Banerjee,et al.  New Difluoro Knoevenagel Condensates of Curcumin, Their Schiff Bases and Copper Complexes as Proteasome Inhibitors and Apoptosis Inducers in Cancer Cells , 2009, Pharmaceutical Research.

[140]  Jian Xiao,et al.  Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents. , 2009, Bioorganic & medicinal chemistry.

[141]  G. Blennow,et al.  A study on the fate of curcumin in the rat. , 2009, Acta pharmacologica et toxicologica.

[142]  Shaker A Mousa,et al.  Emerging nanopharmaceuticals. , 2008, Nanomedicine : nanotechnology, biology, and medicine.

[143]  L. Lim,et al.  In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. , 2008, Toxicology and applied pharmacology.

[144]  I. Gülçin,et al.  Antioxidant and radical scavenging properties of curcumin. , 2008, Chemico-biological interactions.

[145]  S. Joyal,et al.  A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95®CG (Biocurcumax™), A Novel Bioenhanced Preparation of Curcumin , 2008, Indian journal of pharmaceutical sciences.

[146]  S. Vareed,et al.  Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects , 2008, Cancer Epidemiology Biomarkers & Prevention.

[147]  Chatchawan Changtam,et al.  Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice. , 2008, World journal of gastroenterology.

[148]  S. Takeoka,et al.  Loading of curcumin into macrophages using lipid-based nanoparticles. , 2008, International journal of pharmaceutics.

[149]  Ashwini Nangia,et al.  Conformational polymorphism in organic crystals. , 2008, Accounts of chemical research.

[150]  R. Liggins,et al.  Solubilization of hydrophobic drugs by methoxy poly(ethylene glycol)-block-polycaprolactone diblock copolymer micelles: theoretical and experimental data and correlations. , 2008, Journal of pharmaceutical sciences.

[151]  Robert A Newman,et al.  Bioavailability of curcumin: problems and promises. , 2007, Molecular pharmaceutics.

[152]  P. van Bladeren,et al.  Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells. , 2007, Chemical research in toxicology.

[153]  P. Murugan,et al.  Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats. , 2007, Basic & clinical pharmacology & toxicology.

[154]  B. Aggarwal,et al.  Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. , 2007, Carcinogenesis.

[155]  M. Metzler,et al.  Glucuronidation of curcuminoids by human microsomal and recombinant UDP-glucuronosyltransferases. , 2007, Molecular nutrition & food research.

[156]  M. Ricci,et al.  Solid lipid nanoparticles for targeted brain drug delivery. , 2007, Advanced drug delivery reviews.

[157]  Liang Shen,et al.  Theoretical study on physicochemical properties of curcumin. , 2007, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[158]  T. Tsai,et al.  Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[159]  A. Gescher,et al.  Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine , 2007, Cancer Chemotherapy and Pharmacology.

[160]  D. Brocks,et al.  High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin. , 2007, Biomedical chromatography : BMC.

[161]  G. Feldmann,et al.  Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy , 2007, Journal of nanobiotechnology.

[162]  K. N. Babu,et al.  Curcumin — Biological and Medicinal Properties , 2007 .

[163]  P. Mukherjee,et al.  Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. , 2007, International journal of pharmaceutics.

[164]  S. Suresh,et al.  Redetermination of curcumin: (1E,4Z,6E)-5-hydr­oxy-1,7-bis­(4-hydr­oxy-3-methoxy­phen­yl)hepta-1,4,6-trien-3-one , 2007 .

[165]  M. Metzler,et al.  Curcuminoids form reactive glucuronides in vitro. , 2007, Journal of agricultural and food chemistry.

[166]  P. Sandusky,et al.  NMR study of the solution structure of curcumin. , 2007, Journal of natural products.

[167]  N. Huilgol,et al.  Tensiometric Profiles and Their Modulation by Cholesterol: Implications in Cervical Cancer , 2007, Cancer investigation.

[168]  L. Pari,et al.  Tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney. , 2006, Basic & clinical pharmacology & toxicology.

[169]  H. Shibata,et al.  Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer , 2006, Molecular Cancer Therapeutics.

[170]  Eun Kyoung Ryu,et al.  Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. , 2006, Journal of medicinal chemistry.

[171]  S. Wexner,et al.  Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[172]  Suneet Shukla,et al.  Modulation of the function of the multidrug resistance–linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin , 2006, Molecular Cancer Therapeutics.

[173]  L. Lešetický,et al.  The influence of curcumin and manganese complex of curcumin on cadmium‐induced oxidative damage and trace elements status in tissues of mice , 2006, Journal of applied toxicology : JAT.

[174]  Daniel Normolle,et al.  Dose escalation of a curcuminoid formulation , 2006, BMC complementary and alternative medicine.

[175]  M. Metzler,et al.  Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver. , 2006, Journal of agricultural and food chemistry.

[176]  K. Mohri,et al.  Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. , 2005, Biological & pharmaceutical bulletin.

[177]  J. Arbiser,et al.  Synthesis and biological evaluation of aromatic enones related to curcumin. , 2005, Bioorganic & medicinal chemistry.

[178]  K. Glaser,et al.  Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor , 2005, Molecular Cancer Therapeutics.

[179]  M. Pirmohamed,et al.  Phase I Clinical Trial of Oral Curcumin , 2004, Clinical Cancer Research.

[180]  A. Dennison,et al.  Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration , 2004, British Journal of Cancer.

[181]  P. van Bladeren,et al.  Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin. , 2003, Chemical research in toxicology.

[182]  Lei Zhang,et al.  Synthesis and biological evaluation of (-)-laulimalide analogues. , 2003, Organic letters.

[183]  Klaus Schulten,et al.  Water and proton conduction through carbon nanotubes as models for biological channels. , 2003, Biophysical journal.

[184]  T. Slaga,et al.  4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management. , 2003, Neoplasia.

[185]  Jhi-Joung Wang,et al.  Efficacy and irritancy of enhancers on the in‐vitro and in‐vivo percutaneous absorption of curcumin , 2003, The Journal of pharmacy and pharmacology.

[186]  K. Lee,et al.  Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents. , 2002, Bioorganic & medicinal chemistry.

[187]  R. Davey.  Polymorphism in Molecular Crystals Joel Bernstein. Oxford University Press, New York, 2002. ISBN 0198506058. , 2002 .

[188]  Joel Bernstein,et al.  Polymorphism in Molecular Crystals , 2002 .

[189]  G. Kuttan,et al.  Anti-tumour studies of metal chelates of synthetic curcuminoids. , 2002, Journal of experimental & clinical cancer research : CR.

[190]  Ricky A. Sharma,et al.  Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[191]  S. Toyokuni,et al.  Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. , 2001, The Journal of nutrition.

[192]  S. Jee,et al.  Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. , 2001, Anticancer research.

[193]  L. Howells,et al.  Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. , 2001, Cancer research.

[194]  G. Ansari,et al.  Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1. , 2000, Chemico-biological interactions.

[195]  S. Khopde,et al.  Inhibition of Radiation-Induced Lipid Peroxidation by Tetrahydrocurcumin: Possible Mechanisms by Pulse Radiolysis , 2000, Bioscience, biotechnology, and biochemistry.

[196]  A. Dinkova-Kostova,et al.  Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. , 1999, Carcinogenesis.

[197]  M. Majeed,et al.  Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. , 1998, Planta medica.

[198]  Jen-kun Lin,et al.  Stability of curcumin in buffer solutions and characterization of its degradation products. , 1997, Journal of pharmaceutical and biomedical analysis.

[199]  B. Goldin,et al.  Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. , 1997, Biochemical and biophysical research communications.

[200]  N. Vermeulen,et al.  Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. , 1996, Biochemical pharmacology.

[201]  P. Artursson,et al.  Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. , 1991, Biochemical and biophysical research communications.

[202]  H. Tønnesen,et al.  STRUCTURAL STUDIES OF CURCUMINOIDS. I: THE CRYSTAL STRUCTURE OF CURCUMIN , 1982 .

[203]  R. McGhee,et al.  Possible mechanisms for observed pathophysiological variability in experimental spinal cord injury by the method of Allen. , 1976, Journal of neurosurgery.

[204]  W. Mccrone,et al.  Pharmaceutical applications of polymorphism. , 1969, Journal of pharmaceutical sciences.

[205]  P. Rai,et al.  Liposomes Aid Curcumin's Combat with Cancer in a Breast Tumor Model , 2018 .

[206]  Tahereh Arablou,et al.  Curcumin and endometriosis: Review on potential roles and molecular mechanisms. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[207]  E. Roger,et al.  Improvement of Curcumin Bioavailability for Medical Applications , 2018 .

[208]  B. Marcel,et al.  A Curcumin Phospholipid ComplexFormulation Induces Neurogenesis andPrevents Anoikis-Induced Cell Death in an InVitro Gut-Brain Axis Model , 2018 .

[209]  N. Foster,et al.  Polymorphism of curcumin from dense gas antisolvent precipitation , 2017 .

[210]  H. J. Wiggers,et al.  Chapter 7 – Curcumin, a Multitarget Phytochemical: Challenges and Perspectives , 2017 .

[211]  I. Javeri,et al.  Chapter 31 – Curcumin , 2016 .

[212]  Ramesh C. Gupta.  Nutraceuticals : Efficacy, Safety and Toxicity , 2016 .

[213]  N. Siddiqui.  Evaluation of thermo sensitivity of curcumin and quantification of ferulic acid and vanillin as degradation products by a validated HPTLC method. , 2015, Pakistan journal of pharmaceutical sciences.

[214]  B. Aggarwal,et al.  Curcumin glucuronides: assessing the proliferative activity against human cell lines. , 2014, Bioorganic & medicinal chemistry.

[215]  G. Indrayanto,et al.  Chapter Three – Curcumin , 2014 .

[216]  G. Lithgow,et al.  Curcumin and neurodegenerative diseases , 2013, BioFactors.

[217]  Luciana Facco Dalmolin,et al.  Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats. , 2013, Colloids and surfaces. B, Biointerfaces.

[218]  L. Helson.  Curcumin (diferuloylmethane) delivery methods: A review , 2013, BioFactors.

[219]  B. Bao,et al.  Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. , 2012, Cancer research.

[220]  B. Aggarwal,et al.  Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials , 2012, The AAPS Journal.

[221]  T. Chiba,et al.  Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers , 2011, Cancer Chemotherapy and Pharmacology.

[222]  A. Suksamrarn,et al.  Downregulation of p-ERK1/2 and p-AKT expression by curcumin and tetrahydrocurcumin in hepatocellular carcinoma-induced tumors in nude mice , 2011 .

[223]  Anil Kumar,et al.  Conundrum and therapeutic potential of curcumin in drug delivery. , 2010, Critical reviews in therapeutic drug carrier systems.

[224]  J. Snyder,et al.  Highly active anticancer curcumin analogues. , 2007, Advances in experimental medicine and biology.

[225]  Chih-Hung Hsu,et al.  Clinical studies with curcumin. , 2007, Advances in experimental medicine and biology.

[226]  L. Pari,et al.  EFFECT OF TETRAHYDROCURCUMIN ON BLOOD GLUCOSE, PLASMA INSULIN AND HEPATIC KEY ENZYMES IN STREPTOZOTOCIN INDUCED DIABETIC RATS , 2005, Journal of basic and clinical physiology and pharmacology.

[227]  M. Pirmohamed,et al.  Phase I Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance , 2004 .

[228]  Donald J L Jones,et al.  Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[229]  T. Osawa,et al.  The protective effects of tetrahydrocurcumin on oxidative stress in cholesterol-fed rabbits. , 2002, Journal of atherosclerosis and thrombosis.

[230]  T. Masuda,et al.  THE CRYSTAL STRUCTURE AND THE FLUORESCENT PROPERTIES OF CURCUMIN , 1999 .

[231]  P. Kidd,et al.  Phosphatidylcholine: A Superior Protectant Against Liver Damage , 1996 .

[232]  P. Vandiver.  Materials issues in art and archaeology III : symposium held April 27-May 1, 1992, San Francisco, California, U.S.A. , 1992 .