Simulation of Foot-and-Mouth Disease Spread and Effects of Mitigation Strategies to Support Veterinary Contingency Planning in Denmark

To forge a path towards livestock disease emergency preparedness in Denmark, 15 different strategies to mitigate foot-and-mouth disease (FMD) were examined by modelling epidemics initiated in cattle, pig or small ruminant herds across various production systems located in four different Danish regions (Scenario 1), or in one specific livestock production system within each of the three species geographically distributed throughout Denmark (Scenario 2). When additional mitigation strategies were implemented on top of basic control strategies in the European foot-and-mouth disease spread model (EuFMDiS), no significant benefits were predicted in terms of the number of infected farms, the epidemic control duration, and the total economic cost. Further, the model results indicated that the choice of index herd, the resources for outbreak control, and the detection time of FMD significantly influenced the course of an epidemic. The present study results emphasise the importance of basic mitigation strategies, including an effective back-and-forward traceability system, adequate resources for outbreak response, and a high level of awareness among farmers and veterinarians concerning the detection and reporting of FMD at an early stage of an outbreak for FMD control in Denmark.

[1]  A. Breed,et al.  The economic benefits of targeted response strategies against foot-and-mouth disease in Australia. , 2022, Preventive veterinary medicine.

[2]  A. Höflechner-Pöltl,et al.  What Are the Human Resources Required to Control a Foot-and-Mouth Disease Outbreak in Austria? , 2021, Frontiers in Veterinary Science.

[3]  Manuel Magalhães-Sant’Ana,et al.  Stamping Out Animal Culling: From Anthropocentrism to One Health Ethics , 2021, Journal of Agricultural and Environmental Ethics.

[4]  A. Breed,et al.  Comparing surveillance approaches to support regaining free status after a foot-and-mouth disease outbreak. , 2021, Preventive veterinary medicine.

[5]  G. Garner,et al.  Development of a transboundary model of livestock disease in Europe , 2021, bioRxiv.

[6]  Gaël Beaunée,et al.  Multi-species temporal network of livestock movements for disease spread , 2021, Applied Network Science.

[7]  B. Pinior,et al.  The Epidemiological and Economic Impact of a Potential Foot-and-Mouth Disease Outbreak in Austria , 2021, Frontiers in Veterinary Science.

[8]  S. Gubbins,et al.  Foot-and-Mouth Disease Surveillance Using Pooled Milk on a Large-Scale Dairy Farm in an Endemic Setting , 2020, Frontiers in Veterinary Science.

[9]  M. Ward,et al.  The impact of changing farm structure on foot-and-mouth disease spread and control: A simulation study. , 2020, Transboundary and emerging diseases.

[10]  G. Garner,et al.  Management strategies for vaccinated animals after an outbreak of foot-and-mouth disease and the impact on return to trade , 2019, PloS one.

[11]  J. Schulz Simulation modelling of LA-MRSA dispersal and control between swine herds , 2019 .

[12]  M. Nöremark,et al.  Evaluation of Strategies to Control a Potential Outbreak of Foot-and-Mouth Disease in Sweden , 2017, Front. Vet. Sci..

[13]  Anette Boklund,et al.  Resource Estimations in Contingency Planning for Foot-and-Mouth Disease , 2017, Front. Vet. Sci..

[14]  F. Corbière,et al.  Economic assessment of an emerging disease: the case of Schmallenberg virus in France. , 2017, Revue scientifique et technique.

[15]  S. Mortensen,et al.  The costs of preventive activities for exotic contagious diseases-A Danish case study of foot and mouth disease and swine fever. , 2016, Preventive veterinary medicine.

[16]  Paul Wing Hing Kwan,et al.  Improving the computational efficiency of an agent-based spatiotemporal model of livestock disease spread and control , 2016, Environ. Model. Softw..

[17]  T. Halasa,et al.  Improving the Effect and Efficiency of FMD Control by Enlarging Protection or Surveillance Zones , 2015, Front. Vet. Sci..

[18]  M. G. Garner,et al.  A hybrid modeling approach to simulating foot-and-mouth disease outbreaks in Australian livestock , 2015, Front. Environ. Sci..

[19]  H. Mehlhorn World Organization for Animal Health , 2015 .

[20]  Anders Stockmarr,et al.  A Comparison between Two Simulation Models for Spread of Foot-and-Mouth Disease , 2014, PloS one.

[21]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[22]  A. Perez,et al.  Decisions on control of foot-and-mouth disease informed using model predictions. , 2013, Preventive veterinary medicine.

[23]  L. Christiansen,et al.  Comparing control strategies against foot-and-mouth disease: will vaccination be cost-effective in Denmark? , 2013, Preventive veterinary medicine.

[24]  T. Soós,et al.  Control of the deliberate spread of foot-and-mouth disease virus. , 2013, Biosecurity and bioterrorism : biodefense strategy, practice, and science.

[25]  B. Pinior Application of Models for Safeguarding the Milk Supply Chain , 2013 .

[26]  A. Perez,et al.  Factors associated with within-herd transmission of serotype A foot-and-mouth disease virus in cattle, during the 2001 outbreak in Argentina: a protective effect of vaccination. , 2011, Transboundary and emerging diseases.

[27]  B. Martínez-López,et al.  A simulation model for the potential spread of foot-and-mouth disease in the Castile and Leon region of Spain. , 2010, Preventive veterinary medicine.

[28]  Matt J. Keeling,et al.  The role of pre-emptive culling in the control of foot-and-mouth disease , 2009, Proceedings of the Royal Society B: Biological Sciences.

[29]  M C M de Jong,et al.  Foot and mouth disease virus transmission during the incubation period of the disease in piglets, lambs, calves, and dairy cows. , 2009, Preventive veterinary medicine.

[30]  M. D. de Jong,et al.  Quantification of foot-and-mouth disease virus transmission rates using published data. , 2009, ALTEX.

[31]  M C M de Jong,et al.  Foot and mouth disease virus transmission among vaccinated pigs after exposure to virus shedding pigs. , 2007, Vaccine.

[32]  M. D. de Jong,et al.  The effect of vaccination on foot and mouth disease virus transmission among dairy cows. , 2007, Vaccine.

[33]  C. Ribble,et al.  Reporting of suspect cases of foot-and-mouth-disease during the 2001 epidemic in the UK, and the herd sensitivity and herd specificity of clinical diagnosis. , 2007, Preventive veterinary medicine.

[34]  M. Greiner,et al.  Application of non-structural protein antibody tests in substantiating freedom from foot-and-mouth disease virus infection after emergency vaccination of cattle. , 2006, Vaccine.

[35]  M. G. Garner,et al.  An integrated modelling approach to assess the risk of wind-borne spread of foot-and-mouth disease virus from infected premises , 2006 .

[36]  M. G. Garner,et al.  Modelling the spread of foot-and-mouth disease in Australia. , 2005, Australian veterinary journal.

[37]  M. D. de Jong,et al.  Vaccination against foot and mouth disease reduces virus transmission in groups of calves. , 2005, Vaccine.

[38]  Mark C Thurmond,et al.  A Simulation Model of Intraherd Transmission of Foot and Mouth Disease with Reference to Disease Spread before and after Clinical Diagnosis , 2004, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[39]  M. D. de Jong,et al.  The foot-and-mouth disease epidemic in The Netherlands in 2001. , 2003, Preventive veterinary medicine.

[40]  N P French,et al.  Dose-response relationships for foot and mouth disease in cattle and sheep , 2002, Epidemiology and Infection.

[41]  S. Alexandersen,et al.  Further studies to quantify the dose of natural aerosols of foot-and-mouth disease virus for pigs , 2002, Epidemiology and Infection.

[42]  Nathalie Liamine,et al.  European Environment Agency , 2002 .

[43]  J. W. Wilesmith,et al.  Descriptive epidemiology of the 2001 foot-and-mouth disease epidemic in Great Britain: the first five months , 2001, Veterinary Record.

[44]  T Mikkelsen,et al.  Relative risks of the uncontrollable (airborne) spread of FMD by different species , 2001, Veterinary Record.

[45]  J. H. Sørensen,et al.  An integrated model to predict the atmospheric spread of foot-and-mouth disease virus , 2000, Epidemiology and Infection.

[46]  P. Dowling Exotic Diseases of Animals: A Field Guide for Australian Veterinarians , 1996 .

[47]  J. Salt The carrier state in foot and mouth disease--an immunological review. , 1993, The British veterinary journal.

[48]  F. Brown,et al.  An assessment by competition hybridization of the sequence homology between the RNAs of the seven serotypes of FMDV. , 1977, The Journal of general virology.