Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma.

Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma of T/null-cell immunophenotype, characterized by anaplastic cytology and CD30 expression; a subset carries chromo- somal abnormalities involving ALK, and these tumors aberrantly express anaplastic lymphoma kinase (ALK) protein.[

[1]  G. Rassidakis,et al.  Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. , 2005, Human pathology.

[2]  Y. Kwong,et al.  SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. , 2004, Blood.

[3]  K. Hayashi,et al.  Activated Proliferation of B-Cell Lymphomas/Leukemias with the SHP1 Gene Silencing by Aberrant CpG Methylation , 2003, Laboratory Investigation.

[4]  G. Rassidakis,et al.  Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[5]  T. McDonnell,et al.  Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma , 2003, Oncogene.

[6]  K. Hayashi,et al.  Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. , 2002, Cancer research.

[7]  D. Hossfeld.  E.S. Jaffe, N.L. Harris, H. Stein, J.W. Vardiman (eds). World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues , 2002 .

[8]  D. Levy,et al.  Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death , 2002, Oncogene.

[9]  S. Morris,et al.  Translocations involving anaplastic lymphoma kinase (ALK) , 2001, Oncogene.

[10]  J. Turkson,et al.  Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. , 1999, Immunity.