Development of the heart: (2) Septation of the atriums and ventricles

In the first part of our review of cardiac development,1 we discussed the initial changes involved in transformation of the heart forming regions of the embryo into the great veins, the atrial and ventricular chambers, and the arterial trunks. We showed that this first part of cardiac development could be divided into phases of formation of the primary myocardial tube, looping of the tube, during which additional parts are added that give the future compartments their definitive topography, and the assembly of these components into the cardiac chambers and arterial trunks. In this second review, we discuss the processes that complete the separation of the two sides of the definitive heart, for the most part involving septation of the parts of the primary tube not themselves directly involved in formation of the chamber-specific compartments of the atriums and ventricles. In this respect, when concluding our first review, we explained how the arterial trunks were also formed by septation within the solitary outflow tract of the primary heart tube. We also showed, however, that subsequent to formation of the two arterial trunks, there was disappearance of the cushions that initially divided them. Thus, in the definitive heart, the proximal parts of the aorta and pulmonary trunk, along with the sinuses of the arterial roots and the subpulmonary infundibulum, possess their own discrete walls, separated by extra-cardiac space. Although septation by fusion of endocardial cushions will be a topic included in this second review, septation and separation of the outflow tracts is sufficiently complicated to require special treatment. Because of this, we will devote a third review specifically to the mechanisms underscoring the remodelling of the outflow tracts. In this review, therefore, we will confine our considerations to the formation of the atrial, atrioventricular, and ventricular septal structures. As will become …

[1]  Robert H. Anderson,et al.  DEVELOPMENT OF THE HEART: (1) FORMATION OF THE CARDIAC CHAMBERS AND ARTERIAL TRUNKS , 2003, Heart.

[2]  Robert H. Anderson,et al.  Development and structure of the atrial septum , 2002, Heart.

[3]  A. Moorman,et al.  Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken , 2002, The Anatomical record.

[4]  A. Moorman,et al.  Formation of myocardium after the initial development of the linear heart tube. , 2001, Developmental biology.

[5]  M. Richardson,et al.  Development of the human pulmonary vein and its incorporation in the morphologically left atrium , 2001, Cardiology in the Young.

[6]  A. Moorman,et al.  Development of the Myocardium of the Atrioventricular Canal and the Vestibular Spine in the Human Heart , 2001, Circulation research.

[7]  A. Moorman,et al.  Multiple Transcriptional Domains, With Distinct Left and Right Components, in the Atrial Chambers of the Developing Heart , 2000, Circulation research.

[8]  R. Anderson,et al.  Formation of the atrioventricular septal structures in the normal mouse. , 1998, Circulation research.

[9]  R. Anderson,et al.  The anatomy of the heart revisited , 1996, The Anatomical record.

[10]  Fons J. Verbeek,et al.  New Findings Concerning Ventricular Septation in the Human Heart: Implications for Maldevelopment , 1992, Circulation.

[11]  A. Moorman,et al.  Spatial distribution of “tissue‐specific” antigens in the developing human heart and skeletal muscle III. An immunohistochemical analysis of the distribution of the neural tissue antigen G1N2 in the embryonic heart; implications for the development of the atrioventricular conduction system , 1992, The Anatomical record.

[12]  T. Geva,et al.  Ventricular septal defects: how shall we describe, name and classify them? , 1989, Journal of the American College of Cardiology.

[13]  R. Arcilla,et al.  Ventricular trabeculations in the chick embryo heart and their contribution to ventricular and muscular septal development. , 1985, Circulation research.

[14]  M. U. Braimbridge,et al.  Cardiac Anatomy: an Integrated Text and Colour Atlas , 1982 .

[15]  A. Becker,et al.  Atrioventricular septal defects: What's in a name? , 1982, The Journal of thoracic and cardiovascular surgery.

[16]  Vassall-Adams Pr The developing atrioventricular bundle and its branches in relation to small induced ventricular septal defects in the heart of chick embryos. , 1982 .

[17]  R. Anderson,et al.  Developmental anatomy of the membranous part of the ventricular septum in the human heart. , 1979, British heart journal.

[18]  T. R. Forbes,et al.  Human Embryology , 1946, The Yale Journal of Biology and Medicine.

[19]  Dr. Arnold C. G. Wenink Embryology of the ventricular septum , 2004, Virchows Archiv A.

[20]  A. Moorman,et al.  The development of the atrioventricular junction in the human heart. , 1996, Circulation research.

[21]  A. Moorman,et al.  Formation of the tricuspid valve in the human heart. , 1995, Circulation.

[22]  M. Pozzi,et al.  Atrioventricular septal defects. Analysis of short- and medium-term results. , 1991, The Journal of thoracic and cardiovascular surgery.

[23]  M. de la Cruz,et al.  The contribution of the inferior endocardial cushion of the atrioventricular canal to cardiac septation and to the development of the atrioventricular valves: study in the chick embryo. , 1983, The American journal of anatomy.

[24]  P. R. Vassall-Adams The developing atrioventricular bundle and its branches in relation to small induced ventricular septal defects in the heart of chick embryos. , 1982, Journal of anatomy.

[25]  P. Odgers The Development of the Pars Membranacea Septi in the Human Heart. , 1938, Journal of anatomy.

[26]  F Davies,et al.  The Conducting System of the Bird's Heart. , 1930, Journal of anatomy.