Effect of aerobic exercise on cancer‐associated cognitive impairment: A proof‐of‐concept RCT

Change in cognitive ability is a commonly reported adverse effect by breast cancer survivors. The underlying etiology of cognitive complaints is unclear and to date, there is limited evidence for effective intervention strategies. Exercise has been shown to improve cognitive function in older adults and animal models treated with chemotherapy. This proof‐of‐concept randomized controlled trial tested the effect of aerobic exercise versus usual lifestyle on cognitive function in postmenopausal breast cancer survivors.

[1]  Arthur F Kramer,et al.  Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study—Revisited , 2018, Perspectives on psychological science : a journal of the Association for Psychological Science.

[2]  T. Handy,et al.  Altered neural activation during prepotent response inhibition in breast cancer survivors treated with chemotherapy: an fMRI study , 2016, Brain Imaging and Behavior.

[3]  C. A. Brenner,et al.  Sustained attention abnormalities in breast cancer survivors with cognitive deficits post chemotherapy: An electrophysiological study , 2016, Clinical Neurophysiology.

[4]  N. Crone,et al.  Cascade of neural processing orchestrates cognitive control in human frontal cortex , 2016, eLife.

[5]  Kazuki Uemura,et al.  Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

[6]  Kyle R. Noll,et al.  Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer‐related cognitive impairment in adults , 2015, CA: a cancer journal for clinicians.

[7]  L. Jones,et al.  Relationship between exercise behavior, cardiorespiratory fitness, and cognitive function in early breast cancer patients treated with doxorubicin-containing chemotherapy: a pilot study. , 2014, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[8]  G. Winocur,et al.  Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats , 2014, Psychopharmacology.

[9]  Shelli R. Kesler,et al.  Prevalence, mechanisms, and management of cancer-related cognitive impairment , 2014, International review of psychiatry.

[10]  Andra M. Smith,et al.  Persistent Cognitive Changes in Breast Cancer Patients 1 Year Following Completion of Chemotherapy , 2013, Journal of the International Neuropsychological Society.

[11]  H. Praag,et al.  Bridging animal and human models of exercise-induced brain plasticity , 2013, Trends in Cognitive Sciences.

[12]  Andra M. Smith,et al.  Cognitive effects of chemotherapy in breast cancer patients: a dose–response study , 2013, Psycho-oncology.

[13]  S. Ancoli-Israel,et al.  Cognitive complaints after breast cancer treatments: examining the relationship with neuropsychological test performance. , 2013, Journal of the National Cancer Institute.

[14]  J. Root,et al.  Cancer- and cancer treatment-associated cognitive change: an update on the state of the science. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  H. Jim,et al.  Meta-analysis of cognitive functioning in breast cancer survivors previously treated with standard-dose chemotherapy. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  T. Handy,et al.  Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment. , 2012, Archives of internal medicine.

[17]  J. Fardell,et al.  Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity , 2012, Psychopharmacology.

[18]  T. Ahles,et al.  International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. , 2011, The Lancet. Oncology.

[19]  L. Vaughan,et al.  Executive function in daily life: Age-related influences of executive processes on instrumental activities of daily living. , 2010, Psychology and aging.

[20]  Peter Graf,et al.  Resistance training and executive functions: a 12-month randomized controlled trial. , 2010, Archives of internal medicine.

[21]  S. Subramanian,et al.  Confronting chemobrain: an in-depth look at survivors’ reports of impact on work, social networks, and health care response , 2009, Journal of cancer survivorship : research and practice.

[22]  A. Kramer,et al.  Aerobic exercise effects on cognitive and neural plasticity in older adults , 2008, British Journal of Sports Medicine.

[23]  A. Saykin,et al.  Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[24]  Andrew J. Saykin,et al.  Candidate mechanisms for chemotherapy-induced cognitive changes , 2007, Nature Reviews Cancer.

[25]  C. Bielajew,et al.  A Meta-Analysis of the Neuropsychological Effects of Adjuvant Chemotherapy Treatment in Women Treated for Breast Cancer , 2006, The Clinical neuropsychologist.

[26]  Joel Kramer,et al.  A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function , 2005, Cancer.

[27]  Paul Maruff,et al.  The nature and severity of cognitive impairment associated with adjuvant chemotherapy in women with breast cancer: A meta-analysis of the current literature , 2005, Brain and Cognition.

[28]  Paige E. Scalf,et al.  Cardiovascular fitness, cortical plasticity, and aging. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[29]  D. Cella,et al.  Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. , 2002, Journal of pain and symptom management.

[30]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[31]  H. Mayberg,et al.  An ERP study of the temporal course of the Stroop color-word interference effect , 2000, Neuropsychologia.

[32]  Alan C. Evans,et al.  Three-Dimensional MRI Atlas of the Human Cerebellum in Proportional Stereotaxic Space , 1999, NeuroImage.

[33]  M. Muller,et al.  Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma , 1999, Cancer.

[34]  A M Dale,et al.  Randomized event‐related experimental designs allow for extremely rapid presentation rates using functional MRI , 1998, Neuroreport.

[35]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[36]  Jonathan D. Cohen,et al.  Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold , 1995, Magnetic resonance in medicine.

[37]  Karl J. Friston,et al.  Investigations of the functional anatomy of attention using the stroop test , 1993, Neuropsychologia.

[38]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[39]  P. Jacobsen,et al.  Evaluation of the functional assessment of cancer therapy cognitive scale with hematopoietic stem cell transplant patients. , 2007, Journal of pain and symptom management.