CASE Recurrence of Early Gastric Cancer in 5-Years Following Endoscopic Submucosal Dissection

Treatment of choice for early gastric cancer has changed from curative surgery to endoscopic therapy. And the indications for endoscopic treatment of early gastric cancer are expanded. A 70-year-old man was referred for further management of early gastric cancer. In endoscopy, early gastric cancer was suspected at antrum, greater curvature side of gastric body. Endoscopic submucosal dissection was performed. Histology revealed a 6.9×2.7-cm-sized tubular adenocarcinoma, moderately differentiated type and resection margin was negative. Following endoscopy was performed annually. Histology has changed from chronic inflammation to chronic gastritis with intestinal metaplasia, tubular adenoma with low grade dysplasia, tubular adenoma with high grade dysplasia year by year. Laparoscopic subtotal gastrectomy with lymphadenectomy was performed. Histologic finding showed well differentiated tubular adenocarcinoma confined in mucosal layer without lymph node metastasis. (Korean J Helicobacter Up Gastrointest Res 2016;16:160-164)

[1]  M. Kaise,et al.  [Endoscopic resection of early gastric cancer]. , 2012, Nihon rinsho. Japanese journal of clinical medicine.

[2]  Toshiharu Yamaguchi,et al.  Lymph node metastasis from undifferentiated-type mucosal gastric cancer satisfying the expanded criteria for endoscopic resection based on routine histological examination , 2010, Gastric Cancer.

[3]  D. Park,et al.  Lymph node metastasis from intestinal-type early gastric cancer: experience in a single institution and reassessment of the extended criteria for endoscopic submucosal dissection. , 2010, Gastrointestinal endoscopy.

[4]  Kyoung-Mee Kim,et al.  A feasibility study on the expanded indication for endoscopic submucosal dissection of early gastric cancer , 2010, Surgical Endoscopy.

[5]  E. Fukuda,et al.  Clinical Outcomes of Endoscopic Submucosal Dissection for Early Gastric Cancer by Indication Criteria , 2009, Digestion.

[6]  S. Ishikawa,et al.  Indications for EMR/ESD in cases of early gastric cancer: relationship between histological type, depth of wall invasion, and lymph node metastasis , 2007, Gastric Cancer.

[7]  H. Ono.  Early gastric cancer: diagnosis, pathology, treatment techniques and treatment outcomes , 2006, European journal of gastroenterology & hepatology.

[8]  A. De Luca,et al.  Helicobacter pylori and gastric diseases: a dangerous association. , 2004, Cancer letters.

[9]  R. P. Blankfield,et al.  Helicobacter pylori infection and the development of gastric cancer. , 2001, The New England journal of medicine.

[10]  P. Malfertheiner,et al.  Effect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia , 2001, Alimentary pharmacology & therapeutics.

[11]  W. H. Kim,et al.  CpG island methylation in premalignant stages of gastric carcinoma. , 2001, Cancer research.

[12]  Y. Nakanishi,et al.  Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers , 2000, Gastric Cancer.

[13]  F. Chan,et al.  Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions. , 2000, The American journal of pathology.

[14]  T. Kojima,et al.  Outcome of endoscopic mucosal resection for early gastric cancer: review of the Japanese literature. , 1998, Gastrointestinal endoscopy.

[15]  J. Linehan,et al.  Expression of transforming growth factor alpha, epidermal growth factor receptor and epidermal growth factor in precursor lesions to gastric carcinoma. , 1995, British Journal of Cancer.

[16]  P. Correa,et al.  Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. , 1992, Cancer research.