White matter asymmetry in the human brain: a diffusion tensor MRI study.

Language ability and handedness are likely to be associated with asymmetry of the cerebral cortex (grey matter) and connectivity (white matter). Grey matter asymmetry, most likely linked to language has been identified with voxel-based morphometry (VBM) using T(1)-weighted images. Differences in white matter obtained with this technique are less consistent, probably due to the relative insensitivity of the T(1) contrast to the ultrastructure of white matter. Furthermore, previous VBM studies failed to find differences related to handedness in either grey or white matter. We revisited these issues and investigated two independent groups of subjects with diffusion-tensor imaging (DTI) for asymmetries in white matter composition. Using voxel-based statistical analyses an asymmetry of the arcuate fascicle was observed, with higher fractional anisotropy in the left hemisphere. In addition, we show differences related to handedness in the white matter underneath the precentral gyrus contralateral to the dominant hand. Remarkably, these findings were very robust, even when investigating small groups of subjects. This highlights the sensitivity of DTI for white matter tissue differences, making it an ideal tool to study small patient populations.

[1]  N. Geschwind.  Disconnexion syndromes in animals and man. I. , 1965, Brain : a journal of neurology.

[2]  N. Geschwind.  Disconnexion syndromes in animals and man. II. , 1965, Brain : a journal of neurology.

[3]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[4]  Lutz Jäncke,et al.  Anatomical left‐right asymmetry of language‐related temporal cortex is different in left‐ and right‐handers , 1991, Annals of neurology.

[5]  G. Schlaug,et al.  Asymmetry of the planum parietale. , 1994, Neuroreport.

[6]  P. Basser,et al.  Estimation of the effective self-diffusion tensor from the NMR spin echo. , 1994, Journal of magnetic resonance. Series B.

[7]  P. Basser.  Inferring microstructural features and the physiological state of tissues from diffusion‐weighted images , 1995, NMR in biomedicine.

[8]  A. Schleicher,et al.  Asymmetry in the Human Motor Cortex and Handedness , 1996, NeuroImage.

[9]  H. Alkadhi,et al.  Localization of the motor hand area to a knob on the precentral gyrus. A new landmark. , 1997, Brain : a journal of neurology.

[10]  C. Pierpaoli,et al.  Visualizing and characterizing white matter fiber structure and architecture in the human pyramidal tract using diffusion tensor MRI. , 1999, Magnetic resonance imaging.

[11]  Karl J. Friston,et al.  Correlation between structural and functional changes in brain in an idiopathic headache syndrome , 1999, Nature Medicine.

[12]  Karl J. Friston,et al.  Multisubject fMRI Studies and Conjunction Analyses , 1999, NeuroImage.

[13]  Alan C. Evans,et al.  Structural maturation of neural pathways in children and adolescents: in vivo study. , 1999, Science.

[14]  A. Snyder,et al.  Quantitative diffusion-tensor anisotropy brain MR imaging: normative human data and anatomic analysis. , 1999, Radiology.

[15]  J. Finsterbusch,et al.  Rapid isotropic diffusion mapping without susceptibility artifacts: Whole brain studies using diffusion‐weighted single‐shot STEAM MR imaging , 2000, Magnetic resonance in medicine.

[16]  R. Poldrack,et al.  Microstructure of Temporo-Parietal White Matter as a Basis for Reading Ability Evidence from Diffusion Tensor Magnetic Resonance Imaging , 2000, Neuron.

[17]  Karl J. Friston,et al.  Voxel-Based Morphometry—The Methods , 2000, NeuroImage.

[18]  Richard S. J. Frackowiak,et al.  Navigation-related structural change in the hippocampi of taxi drivers. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[19]  K. Amunts,et al.  Interhemispheric asymmetry of the human motor cortex related to handedness and gender , 2000, Neuropsychologia.

[20]  Sinisa Pajevic,et al.  Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: Application to white matter fiber tract mapping in the human brain , 1999, Magnetic resonance in medicine.

[21]  Karl J. Friston,et al.  Cerebral Asymmetry and the Effects of Sex and Handedness on Brain Structure: A Voxel-Based Morphometric Analysis of 465 Normal Adult Human Brains , 2001, NeuroImage.

[22]  J. Baron,et al.  In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease , 2001, NeuroImage.

[23]  J. Rademacher,et al.  Variability and asymmetry in the human precentral motor system. A cytoarchitectonic and myeloarchitectonic brain mapping study. , 2001, Brain : a journal of neurology.

[24]  Alan C. Evans,et al.  Structural asymmetries in the human brain: a voxel-based statistical analysis of 142 MRI scans. , 2001, Cerebral cortex.

[25]  M Cercignani,et al.  Diffusion tensor magnetic resonance imaging in multiple sclerosis , 2001, Neurology.

[26]  Volkmar Glauche,et al.  Distortion-free Diffusion Tensor Imaging of Cranial Nerves and of Inferior Temporal and Orbitofrontal White Matter , 2002, NeuroImage.

[27]  C. Büchel,et al.  Disconnection of speech-relevant brain areas in persistent developmental stuttering , 2022 .

[28]  Marko Wilke,et al.  Correlation of white matter diffusivity and anisotropy with age during childhood and adolescence: a cross-sectional diffusion-tensor MR imaging study. , 2002, Radiology.

[29]  John S. Duncan,et al.  Combined functional MRI and tractography to demonstrate the connectivity of the human primary motor cortex in vivo , 2003, NeuroImage.

[30]  Gareth J. Barker,et al.  Diffusion tractography based group mapping of major white-matter pathways in the human brain , 2003, NeuroImage.

[31]  Stephen Whalen,et al.  Asymmetry of subinsular anisotropy by in vivo diffusion tensor imaging , 2003, Human brain mapping.

[32]  C. Kennard,et al.  The anatomy of visual neglect. , 2003, Brain : a journal of neurology.

[33]  C. Kennard,et al.  The anatomy of visual neglect , 2003 .