Threshold-controlled ubiquitination of the EGFR directs receptor fate

[1]  Han Liu,et al.  Governance of endocytic trafficking and signaling by reversible ubiquitylation. , 2012, Developmental cell.

[2]  K. Vousden,et al.  Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl , 2012, Nature Structural &Molecular Biology.

[3]  A. Weissman,et al.  RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis , 2011, Nature Reviews Cancer.

[4]  L. E. Johannessen,et al.  A Chimeric Pre‐ubiquitinated EGF Receptor is Constitutively Endocytosed in a Clathrin‐Dependent, but Kinase‐Independent Manner , 2011, Traffic.

[5]  A. Musacchio,et al.  Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation , 2011, EMBO reports.

[6]  Yosef Yarden,et al.  Feedback regulation of EGFR signalling: decision making by early and delayed loops , 2011, Nature Reviews Molecular Cell Biology.

[7]  S. Gygi,et al.  Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor , 2010, The Journal of cell biology.

[8]  N. Barkai,et al.  Robust generation and decoding of morphogen gradients. , 2009, Cold Spring Harbor perspectives in biology.

[9]  I. Madshus,et al.  Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking , 2009, Journal of Cell Science.

[10]  S. Simon,et al.  Endocytic trafficking of activated EGFR is AP-2 dependent and occurs through preformed clathrin spots , 2009, Journal of Cell Science.

[11]  P. P. Di Fiore,et al.  Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. , 2008, Developmental cell.

[12]  H. Stenmark,et al.  Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. , 2008, Molecular biology of the cell.

[13]  Roland Eils,et al.  An ultrasensitive sorting mechanism for EGF Receptor Endocytosis , 2008, BMC Systems Biology.

[14]  A. Sorkin,et al.  EGF receptor ubiquitination is not necessary for its internalization , 2007, Proceedings of the National Academy of Sciences.

[15]  G. Kozlov,et al.  Structural Basis for UBA-mediated Dimerization of c-Cbl Ubiquitin Ligase* , 2007, Journal of Biological Chemistry.

[16]  Mirko H. H. Schmidt,et al.  Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport. , 2007, European journal of cell biology.

[17]  Kalle Gehring,et al.  Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. , 2007, Molecular cell.

[18]  D. Bar-Sagi,et al.  Spatial Regulation of EGFR Signaling by Sprouty2 , 2007, Current Biology.

[19]  M. Park,et al.  From Tpr-Met to Met, tumorigenesis and tubes , 2007, Oncogene.

[20]  Arthur D Lander,et al.  Morpheus Unbound: Reimagining the Morphogen Gradient , 2007, Cell.

[21]  M. Mann,et al.  In-gel digestion for mass spectrometric characterization of proteins and proteomes , 2006, Nature Protocols.

[22]  L. E. Johannessen,et al.  EGF‐Induced Activation of the EGF Receptor Does Not Trigger Mobilization of Caveolae , 2006, Traffic.

[23]  I. Dikic,et al.  Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule βPix , 2006, Oncogene.

[24]  M. McNiven,et al.  A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization. , 2006, Cancer research.

[25]  C. Hellberg,et al.  Protein-tyrosine phosphatases and cancer , 2006, Nature Reviews Cancer.

[26]  A. G. Murachelli,et al.  Crystal Structure of the Ubiquitin Binding Domains of Rabex-5 Reveals Two Modes of Interaction with Ubiquitin , 2006, Cell.

[27]  Xuejun Jiang,et al.  Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. , 2006, Molecular cell.

[28]  James Briscoe,et al.  The interpretation of morphogen gradients , 2006, Development.

[29]  M. Nau,et al.  Regulating the regulator: negative regulation of Cbl ubiquitin ligases. , 2006, Trends in biochemical sciences.

[30]  C. Tacchetti,et al.  TTP Specifically Regulates the Internalization of the Transferrin Receptor , 2005, Cell.

[31]  Ivan Dikic,et al.  The Cbl interactome and its functions , 2005, Nature Reviews Molecular Cell Biology.

[32]  Annie Z. Tremp Viral infection: Neurons fight back , 2005, Nature Reviews Microbiology.

[33]  I. Dikic,et al.  Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation , 2005, EMBO reports.

[34]  P. Transidico,et al.  Clathrin-independent endocytosis of ubiquitinated cargos. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[35]  S. Anderson,et al.  Regulation of Ubiquitin Protein Ligase Activity in c-Cbl by Phosphorylation-induced Conformational Change and Constitutive Activation by Tyrosine to Glutamate Point Mutations* , 2004, Journal of Biological Chemistry.

[36]  W. Marshall,et al.  Analysis of Clathrin-mediated Endocytosis of Epidermal Growth Factor Receptor by RNA Interference*[boxs] , 2004, Journal of Biological Chemistry.

[37]  J. Harborth,et al.  Effect of Clathrin Heavy Chain- and α-Adaptin-specific Small Inhibitory RNAs on Endocytic Accessory Proteins and Receptor Trafficking in HeLa Cells* , 2003, Journal of Biological Chemistry.

[38]  S. Fang,et al.  WW Domain HECT E3s Target Cbl RING Finger E3s for Proteasomal Degradation* , 2003, Journal of Biological Chemistry.

[39]  R. Cerione,et al.  Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation , 2003, Cell.

[40]  Xuejun Jiang,et al.  Epidermal Growth Factor Receptor Internalization through Clathrin‐Coated Pits Requires Cbl RING Finger and Proline‐Rich Domains But Not Receptor Polyubiquitylation , 2003, Traffic.

[41]  Pier Paolo Di Fiore,et al.  Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation , 2003, Nature Cell Biology.

[42]  Xuejun Jiang,et al.  Grb2 regulates internalization of EGF receptors through clathrin-coated pits. , 2003, Molecular biology of the cell.

[43]  Y. Yarden,et al.  Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[44]  J. Lippincott-Schwartz,et al.  Role of Grb2 in EGF-stimulated EGFR internalization. , 2002, Journal of cell science.

[45]  Pier Paolo Di Fiore,et al.  A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins , 2002, Nature.

[46]  Y. Yarden,et al.  A mutant EGF‐receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling , 2002, The EMBO journal.

[47]  H. Band,et al.  Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. , 2001, Molecular cell.

[48]  R. Baron,et al.  Src-catalyzed Phosphorylation of c-Cbl Leads to the Interdependent Ubiquitination of Both Proteins* , 2001, The Journal of Biological Chemistry.

[49]  A Ciechanover,et al.  Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. , 1999, Molecular cell.

[50]  Z. Kam,et al.  c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. , 1998, Genes & development.

[51]  H. Wiley,et al.  Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization. , 1990, The Journal of biological chemistry.

[52]  M. Sela,et al.  Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice. , 1988, Journal of the National Cancer Institute.

[53]  H. Herschman,et al.  Variants of 3T3 cells lacking mitogenic response to epidermal growth factor. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[54]  A. Sorkin,et al.  Endocytosis and intracellular trafficking of ErbBs. , 2008, Experimental cell research.

[55]  M. Mann,et al.  Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips , 2007, Nature Protocols.