Berberis aetnensis and B. libanotica: a comparative study on the chemical composition, inhibitory effect on key enzymes linked to Alzheimer's disease and antioxidant activity

This study involves for the first time the evaluation of Berberis aetnensis C. Presl. and Berberis libanotica Ehrenb. ex C.K. Schneid. roots for anticholinesterase and antioxidant properties, with the aim to search compounds possibly useful for the treatment of Alzheimer's disease (AD).

[1]  A. Eid,et al.  Berberis libanotica Ehrenb Extract Shows Anti-Neoplastic Effects on Prostate Cancer Stem/Progenitor Cells , 2014, PloS one.

[2]  I. Singh,et al.  Berberine and its derivatives: a patent review (2009 – 2012) , 2013, Expert opinion on therapeutic patents.

[3]  F. Conforti,et al.  Comparative chemical composition and antioxidant activity of Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) Nyman and Calamintha grandiflora (L.) Moench (Labiatae) , 2012, Natural product research.

[4]  I. Lampronti,et al.  The ethanol fraction from the stem of Berberis libanotica inhibits the viability of adult T cell leukemia , 2012 .

[5]  P. Lan,et al.  Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine. , 2011, Mini reviews in medicinal chemistry.

[6]  B. Lyoussi,et al.  Antioxidant and Antiacetylcholinesterase Activities of Some Commercial Essential Oils and Their Major Compounds , 2011, Molecules.

[7]  Solomon Habtemariam,et al.  The Therapeutic Potential of Berberis darwinii Stem-Bark: Quantification of Berberine and In Vitro Evidence for Alzheimer's Disease Therapy , 2011, Natural product communications.

[8]  Liang Shen,et al.  Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease , 2011, Molecules.

[9]  R. Acquaviva,et al.  Effect of berberine and Berberis aetnensis C. Presl. alkaloid extract on glutamate‐evoked tissue transglutaminase up‐regulation in astroglial cell cultures , 2011, Phytotherapy research : PTR.

[10]  P. Duez,et al.  Correlation between Environmental Factors, Chemical Composition, and Antioxidative Properties of Caper Species Growing Wild in Calabria (South Italy) , 2011, Chemistry & biodiversity.

[11]  I. Kosalec,et al.  Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and Berberis croatica Horvat. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[12]  R. Rawal,et al.  Habitat‐Dependent Variations in Berberine Content of Berberis asiatica Roxb. ex. DC. in Kumaon, Western Himalaya , 2010, Chemistry & biodiversity.

[13]  L. Wimmerova,et al.  Acetylcholinesterase and Butyrylcholinesterase inhibitory activities of Berberis vulgaris , 2010 .

[14]  G. Kulkarni,et al.  A comparative study on the antioxidant activity of methanol extracts of Acacia nilotica and Berberis chitria , 2010 .

[15]  M. Bonesi,et al.  Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae). , 2009, Fitoterapia.

[16]  P. Kakkar,et al.  Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. , 2009, Journal of ethnopharmacology.

[17]  Kinzo Matsumoto,et al.  Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression. , 2009, Biological & pharmaceutical bulletin.

[18]  I. Orhan,et al.  Activity of Essential Oils and Individual Components against Acetyland Butyrylcholinesterase , 2008, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[19]  A. Kinghorn,et al.  Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry) , 2008, Phytotherapy research : PTR.

[20]  R. Tundis,et al.  Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. , 2008, Current medicinal chemistry.

[21]  S. Kulkarni,et al.  Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. , 2007, European journal of pharmacology.

[22]  W. Markesbery,et al.  Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. , 2007, Archives of neurology.

[23]  S. Mehmood,et al.  Wound healing activity of root extracts of Berberis lyceum royle in rats , 2007, Phytotherapy research : PTR.

[24]  G. Blandino,et al.  Activity of Berberis aetnensis root extracts on Candida strains. , 2007, Fitoterapia.

[25]  Lenka Gryčová,et al.  Quaternary protoberberine alkaloids. , 2007, Phytochemistry.

[26]  K. Yoo,et al.  Berberry extract reduces neuronal damage and N-Methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia. , 2006, Biological & pharmaceutical bulletin.

[27]  R. Gacche,et al.  Antioxidant and Possible Anti-Inflammatory Potential of Selected Medicinal Plants Prescribed in the Indian Traditional System of Medicine , 2006 .

[28]  Thierry Gil,et al.  Paratesticular liposarcoma, an unsual presentation of testicular mass , 2006 .

[29]  Wieland Peschel,et al.  Understanding local Mediterranean diets: a multidisciplinary pharmacological and ethnobotanical approach. , 2005, Pharmacological research.

[30]  Sung-Hoon Kim,et al.  Acetylcholinesterase inhibitors from the aerial parts ofCorydalis speciosa , 2004, Archives of pharmacal research.

[31]  S. Aripova,et al.  Berberis Alkaloids. XLI. Alkaloids from Leaves of Cultivated Berberis oblonga , 2003, Chemistry of Natural Compounds.

[32]  A. Speciale,et al.  Berberis aetnensis C. Presl. extracts: antimicrobial properties and interaction with ciprofloxacin. , 2003, International journal of antimicrobial agents.

[33]  J. Hescheler,et al.  Inhibition of Tumor-Induced Angiogenesis and Matrix-Metalloproteinase Expression in Confrontation Cultures of Embryoid Bodies and Tumor Spheroids by Plant Ingredients Used in Traditional Chinese Medicine , 2003, Laboratory Investigation.

[34]  E. Kuepeli,et al.  A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. , 2002, Life sciences.

[35]  Debomoy K Lahiri,et al.  Butyrylcholinesterase: An Important New Target in Alzheimer's Disease Therapy , 2002, International Psychogeriatrics.

[36]  T. Nakanishi,et al.  Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells by a Coptidis Rhizoma Extract and Protoberberine Alkaloids , 2002, Bioscience, biotechnology, and biochemistry.

[37]  LJ Forman,et al.  Free radical oxidative damage and Alzheimer's disease , 2001, The Journal of the American Osteopathic Association.

[38]  M. P. Germanò,et al.  Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity , 2000, Letters in applied microbiology.

[39]  K. Fukuda,et al.  Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. , 1999, Journal of ethnopharmacology.

[40]  R. Scholten,et al.  The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines , 1999, Annals of Internal Medicine.

[41]  B. Nyassé,et al.  A 7,8-dihydro-8-hydroxypalmatine from Enantia chlorantha , 1999 .

[42]  G. Kelly,et al.  Berberine: Therapeutic Potential of an Alkaloid Found in Several Medicinal Plants , 1997 .

[43]  N. Ivanovska,et al.  Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. , 1996, International journal of immunopharmacology.

[44]  A. Palmer,et al.  Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease , 1994, Brain Research.

[45]  M. Mattson,et al.  β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease , 1994 .

[46]  C. Olanow A radical hypothesis for neurodegeneration , 1993, Trends in Neurosciences.

[47]  G. Cordell,et al.  Carbon 13 nmr assignments of berberine and sanguinarine , 1988 .