Low molecular weight intracellular iron transport compounds.

Evidence is presented for the existence of an intracellular pool of low molecular weight iron compounds which acts as an intermediate between extracellular iron and a wide variety of intracellular processes. It is in equilibrium with storage iron and iron enzymes and is of major importance in iron toxicity and chelation therapy.

[1]  J. A. Smith,et al.  Effect of phenylhydrazine-induced haemolysis on the urinary excretion of iron after desferrioxamine. , 1967, Lancet.

[2]  A. Mazur,et al.  Relation of ferritin iron to heme synthesis in marrow and reticulocytes. , 1963, The Journal of biological chemistry.

[3]  A. Jacobs,et al.  The effect of chelating agents on cellular iron metabolism. , 1976, Clinical science and molecular medicine.

[4]  O. Jones,et al.  The utilization of iron and its complexes by mammalian mitochondria. , 1972, The Biochemical journal.

[5]  D. J. Perkins,et al.  Model experiments for the study of iron transfer from transferrin to ferritin. , 2005, European journal of biochemistry.

[6]  E. Wills.  Lipid peroxide formation in microsomes. The role of non-haem iron. , 1969, The Biochemical journal.

[7]  G. R. Bartlett.  Phosphate compounds in rat erythrocytes and reticulocytes. , 1976, Biochemical and biophysical research communications.

[8]  S. Lynch,et al.  Some Factors Affecting the Release of Iron from Reticuloendothelial Cells , 1971, British journal of haematology.

[9]  A. Barnekow,et al.  Microbial iron chelates with iron donor properties in hemoglobin-synthesizing cells. , 1976, Experimental hematology.

[10]  M. Rabinovitz,et al.  Dependence of Polyribosome Structure in Reticulocytes on Iron ; Implication on the Tape Theory of Haemoglobin Synthesis , 1965, Nature.

[11]  M. Youdim,et al.  Biogenic monoamine metabolism and functional activity in iron-deficient rats: behavioural correlates. , 2008, Ciba Foundation symposium.

[12]  T. Peters,et al.  An intracellular protein intermediate for hemoglobin formation. , 1962, The Journal of clinical investigation.

[13]  J. Halliday,et al.  Iron Absorption in the Rat: The Search for Possible Intestinal Mucosal Carriers , 1976, British journal of haematology.

[14]  E. Thomas,et al.  Studies on the partition of iron in bone marrow cells. , 1968, The Journal of clinical investigation.

[15]  T. Bothwell,et al.  STUDIES ON THE FORMATION OF FERRITIN IN RED CELL PRECURSORS. , 1964, The Journal of clinical investigation.

[16]  I. Cavill,et al.  Internal regulation of iron absorption , 1975, Nature.

[17]  R. Person,et al.  Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction. , 1976, The Journal of clinical investigation.

[18]  J. Davis,et al.  Interactions of iron with biogenic amines and ATP , 1976 .

[19]  P. Ponka,et al.  Study of intracellular iron distribution in rabbit reticulocytes with normal and inhibited heme synthesis. , 1973, Biochimica et biophysica acta.

[20]  M. Kaye,et al.  The chelation of iron during intestinal absorption. , 1969, The Journal of laboratory and clinical medicine.

[21]  M. Worwood,et al.  Iron Absorption: Present State of the Art , 1975 .

[22]  K. Konopka,et al.  Studies on the compounds of ATP and iron, isolated from human erythrocytes. , 1969, Clinica chimica acta; international journal of clinical chemistry.

[23]  J. Dominic,et al.  Tyrosine hydroxylase inhibitors. , 1971, Federation proceedings.

[24]  A. Cerami,et al.  The effect of chelating agents on iron mobilization in Chang cell cultures. , 1976, Blood.

[25]  L. Hedenberg.  Studies on iron metabolism with desferrioxamine in man. Experimental and clinical studies. , 1969, Scandinavian journal of haematology. Supplementum.

[26]  A. Carleton,et al.  Mechanism of Plasma Iron Incorporation into Hepatic Ferritin , 1960 .

[27]  T. Bothwell,et al.  The Site of Action of Desferrioxamine , 1971, British journal of haematology.

[28]  A. Jacobs,et al.  Iron Uptake and Ferritin Synthesis by Peripheral Blood Leucocytes from Normal Subjects and Patients with Iron Deficiency and the Anaemia of Chronic Disease , 1976, British journal of haematology.

[29]  L. Blayney,et al.  The effects of iron deficiency on rat liver enzymes. , 1975, British journal of experimental pathology.

[30]  D. Prockop.  Role of iron in the synthesis of collagen in connective tissue. , 1971, Federation proceedings.

[31]  E. Morgan.  A study of iron transfer from rabbit transferrin to reticulocytes using synthetic chelating agents. , 1971, Biochimica et biophysica acta.

[32]  G. R. Bartlett.  Iron nucleotides in human and rat red cells. , 1976, Biochemical and biophysical research communications.

[33]  P. Storring,et al.  Erythropoietin effects on iron metabolism in rat bone marrow cells. , 1975, Biochimica et biophysica acta.

[34]  I. Chanarin,et al.  Reversal of Ineffective Erythropoiesis in Pernicious Anaemia following Vitamin B12 Therapy , 1977, British journal of haematology.

[35]  T. Flatmark,et al.  Energy-dependent accumulation of iron by isolated rat liver mitochondria. I. General features. , 1973, Biochimica et biophysica acta.

[36]  P. Saltman.  The role of chelation in iron metabolism. , 1965, Journal of chemical education.

[37]  J. Fielding,et al.  Desferrioxamine Chelatable Iron in Haemolytic, Megaloblastic and Sideroblastic Anaemias* , 1967, British journal of haematology.

[38]  E. H. Strickland,et al.  Fe3+ uptake by rat-liver mitochondria. , 1965, Biochimica et biophysica acta.