Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death.
暂无分享,去创建一个
R. Schmidt-Ullrich | P. Dent | K. Valerie | D. Reardon | G. Bowers | J. Park | C. Logsdon | C. Logsdon | R. Schmidt‐Ullrich | J. Park
[1] J. Minna,et al. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity. , 1987, Cancer research.
[2] P. Hamilton,et al. Modulation of transforming growth factor alpha‐dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid , 1989, Journal of cellular biochemistry.
[3] K. Valerie,et al. Expression of oestrogen receptor and transforming growth factor-alpha in MCF-7 cells after exposure to fractionated irradiation. , 1992, International journal of radiation biology.
[4] G L Johnson,et al. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. , 1994, Science.
[5] G. Prévost,et al. Evidence for a growth effect of epidermal growth factor on MDA-MB-231 breast cancer cells. , 1994, European journal of cancer.
[6] K. Valerie,et al. Host-cell reactivation of reporter genes introduced into cells by adenovirus as a convenient way to measure cellular DNA repair. , 1995, Mutation research.
[7] Stephen J. Elledge,et al. Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control , 1995, Cell.
[8] K. Kinzler,et al. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. , 1995, Genes & development.
[9] Michael E. Greenberg,et al. Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis , 1995, Science.
[10] G. Johnson,et al. Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase* , 1996, The Journal of Biological Chemistry.
[11] Seamus J. Martin,et al. Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis , 1996, Cell.
[12] E. Adamson,et al. UV activates growth factor receptors via reactive oxygen intermediates , 1996, The Journal of cell biology.
[13] J. Baselga,et al. Autocrine Regulation of Membrane Transforming Growth Factor- Cleavage (*) , 1996, The Journal of Biological Chemistry.
[14] J. Lunec,et al. Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumour cells. , 1996, European journal of cancer.
[15] H. Warenius,et al. Exit from G2 phase after 2 Gy gamma irradiation is faster in radiosensitive human cells with high expression of the RAF1 proto-oncogene. , 1996, Radiation research.
[16] W. A. Yeudall,et al. Growth inhibitory concentrations of EGF induce p21 (WAF1/Cip1) and alter cell cycle control in squamous carcinoma cells. , 1996, Oncogene.
[17] Michael Karin,et al. Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors , 1996, Science.
[18] M. Shannon,et al. The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation. , 1996, Biochimica et biophysica acta.
[19] T. Whiteside,et al. Activation of Raf by ionizing radiation , 1996, Nature.
[20] D. McConkey,et al. Ras signaling in tumor necrosis factor‐induced apoptosis. , 1996, The EMBO journal.
[21] V. Soldatenkov,et al. Antisense raf oligodeoxyribonucleotide is protected by liposomal encapsulation and inhibits Raf-1 protein expression in vitro and in vivo: implication for gene therapy of radioresistant cancer , 1997, Gene Therapy.
[22] M. Shannon,et al. EGF receptor phosphorylation is affected by ionizing radiation. , 1997, Biochimica et Biophysica Acta.
[23] J. Mendelsohn,et al. Epidermal growth factor receptor family and chemosensitization. , 1997, Journal of the National Cancer Institute.
[24] B. Kavanagh,et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation , 1997, Oncogene.
[25] P. Dent,et al. Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast cancer cells , 1997, Oncogene.
[26] E. Lees,et al. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1 , 1997, Molecular and cellular biology.
[27] N. Goldstein,et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. , 1997, The American journal of pathology.
[28] A Sewing,et al. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1 , 1997, Molecular and cellular biology.
[29] P. Leder,et al. Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[30] G. Cooper,et al. Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1 , 1997, Molecular and cellular biology.
[31] J. Baldassare,et al. Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. , 1997, The Biochemical journal.
[32] K. Ellem,et al. UVC activation of the HeLa cell membrane “TGFαASE,” a metalloenzyme , 1997 .
[33] R. Weichselbaum,et al. Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. , 1997, Cancer research.
[34] F. Hobbs,et al. Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase* , 1998, The Journal of Biological Chemistry.
[35] T. Takeuchi,et al. Correlation of epidermal growth factor receptor and radiosensitivity in human maxillary carcinoma cell lines. , 1998, Acta oto-laryngologica.
[36] T. Jacks,et al. Involvement of p53 and p21 in Cellular Defects and Tumorigenesis in Atm−/− Mice , 1998, Molecular and Cellular Biology.
[37] P. Fisher,et al. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells , 1998, Oncogene.
[38] A. Fornace,et al. Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1 , 1998, Oncogene.
[39] D Tripathy,et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[40] M. Ewen,et al. Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest induced by ionizing radiation , 1998, Oncogene.
[41] H. Handa,et al. Involvement of MAP kinase-independent protein kinase C signaling pathway in the EGF-induced p21(WAF1/Cip1) expression and growth inhibition of A431 cells. , 1998, Biochemical and biophysical research communications.
[42] R. DePinho,et al. Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice. , 1998, The Biochemical journal.
[43] R. Schmidt-Ullrich,et al. The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity , 1998, Leukemia.
[44] R. Schmidt-Ullrich,et al. Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation. , 1998, Radiation research.
[45] S. Ménard,et al. Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation , 1998, Oncogene.
[46] S. Hartman,et al. Involvement of Ras in Bruton’s Tyrosine Kinase-mediated JNK Activation* , 1998, The Journal of Biological Chemistry.
[47] L. Pirola,et al. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. , 1998, Molecular biology of the cell.
[48] P. W. Janes,et al. Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells , 1998, Oncogene.
[49] V. Jordan,et al. The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming growth factor alpha mRNA in MDA-MB-231 breast cancer cells stably expressing the oestrogen receptor. , 1998, British Journal of Cancer.
[50] A. Haimovitz-Friedman. Radiation-induced signal transduction and stress response. , 1998, Radiation research.
[51] P. Dent,et al. The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. , 1998, The Biochemical journal.
[52] J E Darnell,et al. Epidermal growth factor-induced growth inhibition requires Stat1 activation. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[53] M. Silvy,et al. Differential dose-dependent effects of epidermal growth factor on gene expression in A431 cells: evidence for a signal transduction pathway that can bypass Raf-1 activation. , 1998, Endocrinology.
[54] L. Norton,et al. Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. , 1998, Cancer research.
[55] P. Dent,et al. Inhibition of the MAPK pathway abrogates BCL2-mediated survival of leukemia cells after exposure to low-dose ionizing radiation. , 1999, Radiation research.
[56] Derek W. Abbott,et al. Mitogen-activated Protein Kinase Kinase 2 Activation Is Essential for Progression through the G2/M Checkpoint Arrest in Cells Exposed to Ionizing Radiation* , 1999, The Journal of Biological Chemistry.
[57] P. Harari,et al. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. , 1999, Cancer research.
[58] R. Schmidt-Ullrich,et al. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[59] J. Contessa,et al. Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells , 1999, Oncogene.