Structure–activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides
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Ling Wang | Xin Ming | Ling Wang | R. Juliano | X. Ming | F. Tavares | M. Suto | Chengqiong Mao | Rudolph L Juliano | Francis Tavares | Edward G Brown | Lindsey James | Yamuna Ariyarathna | Chengqiong Mao | Mark Suto | L. James | Yamuna Ariyarathna | Edward G. Brown | Francis X. Tavares | Xin Ming
[1] Hong Cao,et al. Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs , 2015, Nucleic acids research.
[2] Judy Lieberman,et al. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown , 2015, Nature Biotechnology.
[3] V. Venditto,et al. Designer lipids for drug delivery: from heads to tails. , 2014, Journal of controlled release : official journal of the Controlled Release Society.
[4] D. Corey,et al. Silencing disease genes in the laboratory and the clinic , 2012, The Journal of pathology.
[5] Sarah Seifert,et al. Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape , 2013, Nature Biotechnology.
[6] Peter Vandenabeele,et al. Determination of apoptotic and necrotic cell death in vitro and in vivo. , 2013, Methods.
[7] A. Krainer,et al. RNA therapeutics: beyond RNA interference and antisense oligonucleotides , 2012, Nature Reviews Drug Discovery.
[8] M. Jäättelä,et al. Lysosomal cell death at a glance , 2013, Journal of Cell Science.
[9] J. Gruenberg,et al. Lipid sorting and multivesicular endosome biogenesis. , 2013, Cold Spring Harbor perspectives in biology.
[10] S. Crooke,et al. Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides , 2017, Nucleic acids research.
[11] E. Wickstrom. DNA and RNA derivatives to optimize distribution and delivery. , 2015, Advanced drug delivery reviews.
[12] H. Cai,et al. Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. , 2007, Developmental cell.
[13] Shimeng Liu,et al. Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine. , 2014, Nanomedicine.
[14] G. Kroemer,et al. Lysosomal membrane permeabilization in cell death , 2008, Oncogene.
[15] R. L. Juliano,et al. High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides , 2015, Nucleic acids research.
[16] Shi Xu,et al. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. , 2013, Advanced drug delivery reviews.
[17] R. Juliano,et al. Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides. , 2012, Bioconjugate chemistry.
[18] G. Salvesen,et al. Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues* , 2008, Journal of Biological Chemistry.
[19] D. Green,et al. Die another way – non-apoptotic mechanisms of cell death , 2014, Journal of Cell Science.
[20] S. Dowdy. Overcoming cellular barriers for RNA therapeutics , 2017, Nature Biotechnology.
[21] Herbert Waldmann,et al. Identification of siRNA delivery enhancers by a chemical library screen , 2015, Nucleic acids research.
[22] M. Abrahamson,et al. Inhibition of lipopolysaccharide‐induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors , 2017, Journal of leukocyte biology.
[23] Madelyn Light,et al. Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells , 2014, Nucleic acids research.
[24] G. Cheng,et al. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses , 2013, Proceedings of the National Academy of Sciences.
[25] C. Ungermann,et al. Principles of membrane tethering and fusion in endosome and lysosome biogenesis. , 2014, Current opinion in cell biology.
[26] Stanley T Crooke,et al. Cellular uptake and trafficking of antisense oligonucleotides , 2017, Nature Biotechnology.
[27] S. Emr,et al. A Nobel Prize for membrane traffic: Vesicles find their journey’s end , 2013, The Journal of cell biology.
[28] C. Stein,et al. FDA-Approved Oligonucleotide Therapies in 2017. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.
[29] B. Shutinoski,et al. Cathepsins Limit Macrophage Necroptosis through Cleavage of Rip1 Kinase , 2014, The Journal of Immunology.
[30] S. Kornbluth,et al. Cellular mechanisms controlling caspase activation and function. , 2013, Cold Spring Harbor perspectives in biology.
[31] G. Robertson,et al. Effect of lysosomotropic molecules on cellular homeostasis , 2017, Pharmacological research.
[32] B. Sullenger,et al. From the RNA world to the clinic , 2016, Science.
[33] Gert Storm,et al. Endosomal escape pathways for delivery of biologicals. , 2011, Journal of controlled release : official journal of the Controlled Release Society.
[34] H. Soifer,et al. Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents , 2009, Nucleic acids research.
[35] M. Manoharan,et al. Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes , 2011, Nucleic acids research.
[36] R. Juliano,et al. The delivery of therapeutic oligonucleotides , 2016, Nucleic acids research.
[37] P. Boisguérin,et al. Delivery of therapeutic oligonucleotides with cell penetrating peptides☆ , 2015, Advanced Drug Delivery Reviews.
[38] John J Rossi,et al. RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise? , 2016, Annual review of pharmacology and toxicology.
[39] Ari Helenius,et al. Endosome maturation , 2011, The EMBO journal.
[40] Thomas Farkas,et al. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. , 2005, Cancer research.
[41] Maria Markaki,et al. Crosstalk between apoptosis, necrosis and autophagy. , 2013, Biochimica et biophysica acta.
[42] J. Cintrat,et al. The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides , 2013, Nucleic acids research.
[43] W. Janzen,et al. A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides. , 2017, ACS chemical biology.
[44] J. Gruenberg,et al. Endosome maturation, transport and functions. , 2014, Seminars in cell & developmental biology.
[45] B. Chazotte. Labeling lysosomes in live cells with LysoTracker. , 2011, Cold Spring Harbor protocols.
[46] B. Brodská,et al. Dose‐dependent effects of the caspase inhibitor Q‐VD‐OPh on different apoptosis‐related processes , 2011, Journal of cellular biochemistry.
[47] V. Haucke,et al. At the Crossroads of Chemistry and Cell Biology: Inhibiting Membrane Traffic by Small Molecules , 2012, Traffic.
[48] P. Angus,et al. Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis. , 2014, The Journal of general virology.
[49] Xiaoyuan Chen,et al. Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis , 2008, Nucleic acids research.
[50] Wenqing Gao,et al. Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. , 2017, Trends in biochemical sciences.
[51] George A. Calin,et al. RNAi Therapies: Drugging the Undruggable , 2014, Science Translational Medicine.
[52] S. Pfeffer. Rab GTPase regulation of membrane identity. , 2013, Current opinion in cell biology.
[53] B. Baker,et al. Pharmacology of Antisense Drugs. , 2017, Annual review of pharmacology and toxicology.
[54] Samir El Andaloussi,et al. Delivery is key: lessons learnt from developing splice‐switching antisense therapies , 2017, EMBO molecular medicine.