BACE: Therapeutic target and potential biomarker for Alzheimer's disease.
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[1] Christopher G. Wilson,et al. BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration , 2010, The Journal of Neuroscience.
[2] G. Tesco,et al. Ubiquitin Regulates GGA3-mediated Degradation of BACE1* , 2010, The Journal of Biological Chemistry.
[3] M. Weiner,et al. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease , 2010, Nature Reviews Neurology.
[4] P. Wong,et al. The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential , 2009, The Journal of Neuroscience.
[5] A. Turner,et al. Cell biology, regulation and inhibition of β‐secretase (BACE‐1) , 2009, The FEBS journal.
[6] Marc Tessier-Lavigne,et al. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases , 2009, Nature.
[7] J. Stockley,et al. Understanding BACE1: essential protease for amyloid-β production in Alzheimer’s disease , 2008, Cellular and Molecular Life Sciences.
[8] M. Wolfe,et al. Promotion of BACE1 mRNA Alternative Splicing Reduces Amyloid β-Peptide Production* , 2008, Journal of Biological Chemistry.
[9] D. Price,et al. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice , 2008, Proceedings of the National Academy of Sciences.
[10] G. Evin,et al. BACE inhibitors as potential therapeutics for Alzheimer's disease. , 2007, Recent patents on CNS drug discovery.
[11] P. Wong,et al. Bace1 modulates myelination in the central and peripheral nervous system , 2006, Nature Neuroscience.
[12] Colin L Masters,et al. Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway. , 2006, Brain : a journal of neurology.
[13] J. Walter. Control of Amyloid-β-Peptide Generation by Subcellular Trafficking of the β-Amyloid Precursor Protein and β-Secretase , 2006, Neurodegenerative Diseases.
[14] Inder M Verma,et al. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model , 2005, Nature Neuroscience.
[15] Wanpin Chang,et al. GGA Proteins Mediate the Recycling Pathway of Memapsin 2 (BACE)* , 2005, Journal of Biological Chemistry.
[16] B. Hyman,et al. Beta-secretase activity increases with aging in human, monkey, and mouse brain. , 2004, The American journal of pathology.
[17] M. Ohno,et al. BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease , 2004, Neuron.
[18] Colin L Masters,et al. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets , 2003, Journal of neuroscience research.
[19] M. Pangalos,et al. BACE1 (β-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes , 2003, Molecular and Cellular Neuroscience.
[20] N. Hooper,et al. Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[21] P. Wong,et al. Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease , 2003, Nature Medicine.
[22] B. Hyman,et al. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. , 2002, Archives of neurology.
[23] C. Masters,et al. Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease , 2002 .
[24] R. Vassar. The beta-secretase, BACE: a prime drug target for Alzheimer's disease. , 2001, Journal of molecular neuroscience : MN.
[25] G. Multhaup,et al. A Splice Variant of β-Secretase Deficient in the Amyloidogenic Processing of the Amyloid Precursor Protein* , 2001, The Journal of Biological Chemistry.
[26] L Hong,et al. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. , 2000, Science.
[27] M. Citron,et al. Expression Analysis of BACE2 in Brain and Peripheral Tissues* , 2000, The Journal of Biological Chemistry.
[28] J. Tang,et al. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[29] Alfredo G. Tomasselli,et al. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity , 1999, Nature.
[30] R. Barbour,et al. Purification and cloning of amyloid precursor protein β-secretase from human brain , 1999, Nature.
[31] David G. Tew,et al. Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase , 1999, Molecular and Cellular Neuroscience.
[32] J. Treanor,et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. , 1999, Science.