Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours
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David T. W. Jones | F. Westermann | M. Kool | T. Pugh | N. Jäger | S. Pfister | Malcolm A. Smith | J. Molenaar | M. Haber | T. Milde | G. Schleiermacher | A. Banito | T. G. Grünewald | A. Nabbi
[1] I. Pollack,et al. LGG-04. A PHASE II RE-TREATMENT STUDY OF SELUMETINIB FOR RECURRENT OR PROGRESSIVE PEDIATRIC LOW-GRADE GLIOMA (pLGG): A PEDIATRIC BRAIN TUMOR CONSORTIUM (PBTC) STUDY , 2020, Neuro-Oncology.
[2] P. Sorensen,et al. Ewing Sarcoma , 2020, Sarcomas.
[3] R. Russell,et al. EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma. , 2019, Neuro-oncology.
[4] S. Grupp,et al. Naïve T-cell Deficits at Diagnosis and after Chemotherapy Impair Cell Therapy Potential in Pediatric Cancers. , 2019, Cancer discovery.
[5] P. Agius,et al. Immunogenic neoantigens derived from gene fusions stimulate T cell responses , 2019, Nature Medicine.
[6] Katharine L. Diehl,et al. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism , 2019, Nature Communications.
[7] K. Stegmaier,et al. Ushering in the next generation of precision trials for pediatric cancer , 2019, Science.
[8] Jessica L. Davis,et al. TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening. , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[9] P. Northcott,et al. Medulloblastoma , 2019, Nature Reviews Disease Primers.
[10] T. Chan,et al. The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy , 2019, Nature Reviews Cancer.
[11] Thomas P. Howard,et al. MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. , 2019, Cancer research.
[12] G. Curigliano,et al. Safety and Tolerability of Phosphatidylinositol-3-Kinase (PI3K) Inhibitors in Oncology , 2019, Drug Safety.
[13] P. Sorensen,et al. CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors , 2019, Clinical Cancer Research.
[14] C. Brennan,et al. Tumor mutational load predicts survival after immunotherapy across multiple cancer types , 2019, Nature Genetics.
[15] S. PlantAshley,et al. Immunotherapy and the Immune Infiltrate in Pediatric Brain Tumors: An Illustration and Review of the Unique Challenges Facing Immunotherapy for Pediatric Oncology , 2018 .
[16] Plant Ashley S,et al. Immunotherapy and the Immune Infiltrate in Pediatric Brain Tumors: An Illustration and Review of the Unique Challenges Facing Immunotherapy for Pediatric Oncology , 2018, International Journal of Immunology and Immunotherapy.
[17] F. Westermann,et al. A mechanistic classification of clinical phenotypes in neuroblastoma , 2018, Science.
[18] Dirk Mossmann,et al. mTOR signalling and cellular metabolism are mutual determinants in cancer , 2018, Nature Reviews Cancer.
[19] J. Sicklick,et al. Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted Therapeutics. , 2018, JCO precision oncology.
[20] David T. W. Jones,et al. A biobank of patient-derived pediatric brain tumor models , 2018, Nature Medicine.
[21] David T. W. Jones,et al. Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[22] R. Siebert,et al. Family-based germline sequencing in children with cancer , 2018, Oncogene.
[23] Jill S Barnholtz-Sloan,et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015. , 2018, Neuro-oncology.
[24] Xiaotu Ma,et al. Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome , 2018, Nature Communications.
[25] Nicholas Light,et al. Ewing‐like sarcoma: An emerging family of round cell sarcomas , 2018, Journal of cellular physiology.
[26] N. Schultz,et al. A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT) , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[27] B. Dickson,et al. Response to Immune Checkpoint Inhibition in Two Patients with Alveolar Soft-Part Sarcoma , 2018, Cancer Immunology Research.
[28] S. Raimondi,et al. Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high‐grade and diffuse intrinsic pontine glioma , 2018, Pediatric blood & cancer.
[29] J. Maris,et al. Abstract LB-136: Pediatric Preclinical Testing Consortium evaluation of a DLL3-targeted antibody drug conjugate rovalpituzumab tesirine, in neuroblastoma , 2018, Clinical Research (Excluding Clinical Trials).
[30] Mariella G. Filbin,et al. Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma , 2018, Acta Neuropathologica Communications.
[31] David T. W. Jones,et al. Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas , 2018, Acta Neuropathologica.
[32] T. Cripe,et al. Pediatric Cancer Immunotherapy: Opportunities and Challenges , 2018, Pediatric Drugs.
[33] R. Young,et al. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry , 2018, Nature Genetics.
[34] E. de Álava,et al. Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas? , 2018, Modern Pathology.
[35] David T. W. Jones,et al. Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial. , 2018, The Lancet. Oncology.
[36] Gang Liu,et al. A cohort study , 2018 .
[37] S. Jason,et al. Neuroblastoma , 2018, Definitions.
[38] O. Delattre,et al. Transcriptomic definition of molecular subgroups of small round cell sarcomas , 2018, The Journal of pathology.
[39] Jessica L. Davis,et al. Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study. , 2018, The Lancet. Oncology.
[40] C. Klein,et al. CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies , 2018, Clinical Cancer Research.
[41] W. Foulkes,et al. Hereditary SWI/SNF complex deficiency syndromes. , 2018, Seminars in diagnostic pathology.
[42] Jaewhan Song,et al. Regulatory Network of ARF in Cancer Development , 2018, Molecules and cells.
[43] Steven J. M. Jones,et al. Pathogenic Germline Variants in 10,389 Adult Cancers. , 2018, Cell.
[44] H. Lo,et al. Inhibiting TRK Proteins in Clinical Cancer Therapy , 2018, Cancers.
[45] David T. W. Jones,et al. Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information , 2018, Modern Pathology.
[46] Michael C. Heinold,et al. The landscape of genomic alterations across childhood cancers , 2018, Nature.
[47] David T. W. Jones,et al. DNA methylation-based classification of central nervous system tumours , 2018, Nature.
[48] S. Pfister,et al. Response in a child with a BRAF V600E mutated desmoplastic infantile astrocytoma upon retreatment with vemurafenib , 2018, Pediatric blood & cancer.
[49] Funda Meric-Bernstam,et al. Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children , 2018, The New England journal of medicine.
[50] Christopher W Mount,et al. Potent antitumor efficacy of anti-GD2 CAR T-cells in H3K27M+ diffuse midline gliomas , 2018, Nature Medicine.
[51] Xin Zhou,et al. Pan-cancer genome and transcriptome analyses of 1,699 pediatric leukemias and solid tumors , 2018, Nature.
[52] D. Nowis,et al. Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis , 2018, PLoS medicine.
[53] M. Roussel,et al. Establishing a Preclinical Multidisciplinary Board for Brain Tumors , 2018, Clinical Cancer Research.
[54] Birgit Geoerger,et al. Precision medicine in pediatric oncology , 2017, Current opinion in pediatrics.
[55] Navaneethan Radhakrishnan,et al. Identifying synthetic lethal targets using CRISPR/Cas9 system. , 2017, Methods.
[56] K. Hess,et al. Characteristics and outcomes of patients with advanced sarcoma enrolled in early phase immunotherapy trials , 2017, Journal of Immunotherapy for Cancer.
[57] Anne Song,et al. Therapeutic Targeting of Ependymoma as Informed by Oncogenic Enhancer Profiling , 2017, Nature.
[58] Steven B. Neuhauser,et al. PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. , 2017, Cancer research.
[59] Kun Mu,et al. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma , 2017, Cancer cell.
[60] A. Manabe,et al. Phase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors , 2017, Oncoimmunology.
[61] D. Busch,et al. Systematic identification of cancer-specific MHC-binding peptides with RAVEN , 2017, bioRxiv.
[62] J. Khan,et al. Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. , 2017, Cancer cell.
[63] J. Foster,et al. Dinutuximab for the treatment of pediatric patients with neuroblastoma. , 2017, Drugs of today.
[64] S. Kaste,et al. Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor , 2017, Oncotarget.
[65] Qing-Rong Chen,et al. A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor , 2017, Nature Genetics.
[66] M. Lim,et al. Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children's Oncology Group Study. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[67] J. Huse,et al. Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy , 2017, Neuro-oncology.
[68] M. Prados,et al. A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study , 2017, Neuro-oncology.
[69] Anang A. Shelat,et al. Orthotopic Patient-Derived Xenografts of Pediatric Solid Tumors , 2017, Nature.
[70] P. Varlet,et al. Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial , 2017, Clinical Cancer Research.
[71] D. Johnston,et al. Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome , 2017, Acta Neuropathologica.
[72] F. Speleman,et al. Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma , 2017, Oncotarget.
[73] Sirintra Nakjang,et al. Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study , 2017, The Lancet. Oncology.
[74] Roland Eils,et al. The whole-genome landscape of medulloblastoma subtypes , 2017, Nature.
[75] David T. W. Jones,et al. From class waivers to precision medicine in paediatric oncology. , 2017, The Lancet. Oncology.
[76] P. Iversen,et al. Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations , 2017, Clinical Cancer Research.
[77] A. Goldenberg,et al. Intertumoral Heterogeneity within Medulloblastoma Subgroups. , 2017, Cancer cell.
[78] M. Loh,et al. Precision Medicine in Pediatric Oncology: Translating Genomic Discoveries into Optimized Therapies , 2017, Clinical Cancer Research.
[79] O. Delattre,et al. Feasibility and clinical integration of molecular profiling for target identification in pediatric solid tumors , 2017, Pediatric blood & cancer.
[80] S. Plon,et al. Pediatric Cancer Predisposition and Surveillance: An Overview, and a Tribute to Alfred G. Knudson Jr , 2017, Clinical Cancer Research.
[81] K. Davis,et al. ADVL1412: Initial results of a phase I/II study of nivolumab and ipilimumab in pediatric patients with relapsed/refractory solid tumors—A COG study. , 2017 .
[82] B. Geoerger,et al. Phase 1/2 KEYNOTE-051 study of pembrolizumab (pembro) in pediatric patients (pts) with advanced melanoma or a PD-L1+ advanced, relapsed, or refractory solid tumor or lymphoma. , 2017 .
[83] M. Kowgier,et al. A phase I/II study of atezolizumab in pediatric and young adult patients with refractory/relapsed solid tumors (iMATRIX-Atezolizumab). , 2017 .
[84] M. Ladanyi,et al. DNA Methylation-Based Classifier for Accurate Molecular Diagnosis of Bone Sarcomas. , 2017, JCO precision oncology.
[85] S. Pfister,et al. Early phase clinical trials of anticancer agents in children and adolescents — an ITCC perspective , 2017, Nature Reviews Clinical Oncology.
[86] T. Mcclanahan,et al. Patterns of PD‐1, PD‐L1, and PD‐L2 expression in pediatric solid tumors , 2017, Pediatric blood & cancer.
[87] M. Lim,et al. Target and Agent Prioritization for the Children’s Oncology Group—National Cancer Institute Pediatric MATCH Trial , 2017, Journal of the National Cancer Institute.
[88] M. Fischer,et al. A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors , 2017, Clinical Cancer Research.
[89] David T. W. Jones,et al. H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers , 2017, Acta Neuropathologica.
[90] C. Mackall,et al. Harnessing the Immunotherapy Revolution for the Treatment of Childhood Cancers. , 2017, Cancer cell.
[91] D. Steinemann,et al. Childhood cancer predisposition syndromes—A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology , 2017, American journal of medical genetics. Part A.
[92] James D. Brenton,et al. Liquid biopsies come of age: towards implementation of circulating tumour DNA , 2017, Nature Reviews Cancer.
[93] N. Ratner,et al. Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas. , 2016, The New England journal of medicine.
[94] Stuart J. Andrews,et al. Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations , 2016, Genome Medicine.
[95] Jonathan M Marron,et al. Patient/parent perspectives on genomic tumor profiling of pediatric solid tumors: The Individualized Cancer Therapy (iCat) experience , 2016, Pediatric blood & cancer.
[96] Richard C. McEachin,et al. Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas , 2016, Science Translational Medicine.
[97] Roland Eils,et al. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma , 2016, Nature Medicine.
[98] Peter J Houghton,et al. Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis. , 2016, Cancer research.
[99] D. Merico,et al. Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[100] A. Panigrahy,et al. Antigen-specific immunoreactivity and clinical outcome following vaccination with glioma-associated antigen peptides in children with recurrent high-grade gliomas: results of a pilot study , 2016, Journal of Neuro-Oncology.
[101] M. Frühwald,et al. Immunotherapy in atypical teratoid-rhabdoid tumors: Data from a survey of the HGG-Immuno Group. , 2016, Cytotherapy.
[102] David T. W. Jones,et al. Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. , 2016, European journal of cancer.
[103] A. Panigrahy,et al. Immune responses and outcome after vaccination with glioma-associated antigen peptides and poly-ICLC in a pilot study for pediatric recurrent low-grade gliomas. , 2016, Neuro-oncology.
[104] M. Yalon,et al. Pembrolizumab: first experience with recurrent primary central nervous system (CNS) tumors , 2016, Journal of Neuro-Oncology.
[105] Mei Lu,et al. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. , 2016, Cancer cell.
[106] Tao Wang,et al. Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors. , 2016, JAMA oncology.
[107] B. Crompton,et al. Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study. , 2016, JAMA oncology.
[108] C. Bult,et al. Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop. , 2016, Cancer genetics.
[109] H. Meijers-Heijboer,et al. Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes , 2016, Scientific Reports.
[110] R. Versteeg,et al. High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition , 2016, Oncotarget.
[111] C. Antonescu,et al. Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes , 2016, Genes, chromosomes & cancer.
[112] Sara M. Federico,et al. The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities. , 2016, Developmental biology.
[113] Roland Eils,et al. Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. , 2016, Cancer cell.
[114] Birgit Kasch,et al. Next Generation , 2005, Im OP.
[115] Roland Eils,et al. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs , 2016, Cell.
[116] S. Steinberg,et al. Adjuvant Immunotherapy to Improve Outcome in High-Risk Pediatric Sarcomas , 2016, Clinical Cancer Research.
[117] Roland Eils,et al. Active medulloblastoma enhancers reveal subgroup-specific cellular origins , 2016, Nature.
[118] Liliana Goumnerova,et al. MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism , 2016, Nature Genetics.
[119] Alan Ashworth,et al. BRCAness revisited , 2016, Nature Reviews Cancer.
[120] L. Zitvogel,et al. Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. , 2015, Cancer cell.
[121] Li Ding,et al. Germline Mutations in Predisposition Genes in Pediatric Cancer. , 2015, The New England journal of medicine.
[122] Joshua A. Bittker,et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action , 2015, Nature chemical biology.
[123] D. Wheeler,et al. Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney , 2015, Nature Communications.
[124] Thomas P. Howard,et al. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 , 2015, Nature Medicine.
[125] J. Wolchok,et al. Phase I Clinical Trial of Ipilimumab in Pediatric Patients with Advanced Solid Tumors , 2015, Clinical Cancer Research.
[126] Joshua A. Bittker,et al. Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. , 2015, Cancer discovery.
[127] M. Yalon,et al. IMCT-01PEMBROLIZUMAB: FIRST EXPERIENCE WITH RECURRENT PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS , 2015 .
[128] A. Pession,et al. Whole transcriptome sequencing identifies BCOR internal tandem duplication as a common feature of clear cell sarcoma of the kidney , 2015, OncoTarget.
[129] Joshua M. Korn,et al. High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response , 2015, Nature Medicine.
[130] Simon C Watkins,et al. Telomerase activation by genomic rearrangements in high-risk neuroblastoma , 2015, Nature.
[131] Nallasivam Palanisamy,et al. Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth. , 2015, JAMA.
[132] P. Houghton,et al. Inhibition of MDM2 by RG7388 confers hypersensitivity to X‐radiation in xenograft models of childhood sarcoma , 2015, Pediatric blood & cancer.
[133] Michael C. Rusch,et al. Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[134] Gudrun Schleiermacher,et al. Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations , 2015, Nature Genetics.
[135] M. Fukuzawa,et al. Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney , 2015, Nature Genetics.
[136] T. Garrington,et al. Non-Rhabdomyosarcoma Soft Tissue Sarcomas in Children: A Surveillance, Epidemiology, and End Results Analysis Validating COG Risk Stratifications. , 2015, International journal of radiation oncology, biology, physics.
[137] S. Wootton-Gorges,et al. Malignant renal tumors in children , 2015, Journal of kidney cancer and VHL.
[138] Sohita Dhillon. Dinutuximab: First Global Approval , 2015, Drugs.
[139] Gary D Bader,et al. Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. , 2015, Cancer cell.
[140] Bo Wen,et al. Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo. , 2015, Cancer cell.
[141] M. Kool,et al. Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma , 2015, Acta neuropathologica communications.
[142] Richard A. Moore,et al. Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors. , 2015, Cancer cell.
[143] Eckart Meese,et al. Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. , 2015, Cancer cell.
[144] Florence I. Raynaud,et al. Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease , 2015, Cancer cell.
[145] Bandana Sharma,et al. CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer , 2014, Cell.
[146] Chris Jones,et al. Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma , 2014, Nature Reviews Cancer.
[147] Li Ding,et al. Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. , 2014, Cancer discovery.
[148] Jill S. Barnholtz-Sloan,et al. Childhood Brain Tumor Epidemiology: A Brain Tumor Epidemiology Consortium Review , 2014, Cancer Epidemiology, Biomarkers & Prevention.
[149] A. McKenna,et al. The genomic landscape of pediatric Ewing sarcoma. , 2014, Cancer discovery.
[150] Narasimhan P. Agaram,et al. Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: Evidence for a common pathogenesis , 2014, Genes, chromosomes & cancer.
[151] C. Stewart,et al. Deriving therapies for children with primary CNS tumors using pharmacokinetic modeling and simulation of cerebral microdialysis data. , 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[152] P. Grundy,et al. Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour , 2014, Nature Communications.
[153] David M. Thomas,et al. Li-Fraumeni syndrome: cancer risk assessment and clinical management , 2014, Nature Reviews Clinical Oncology.
[154] Stephen Yip,et al. Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma , 2014, Nature Genetics.
[155] Liliana Goumnerova,et al. Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma , 2014, Nature Genetics.
[156] Amar Gajjar,et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma , 2014, Nature Genetics.
[157] Michael Brudno,et al. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations , 2014, Nature Genetics.
[158] G. Getz,et al. Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. , 2014, Cancer discovery.
[159] David T. W. Jones,et al. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge , 2014, Nature Reviews Cancer.
[160] C. French. NUT midline carcinoma , 2014, Nature Reviews Cancer.
[161] Roland Eils,et al. Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas , 2013, Genome Biology.
[162] V. Amani,et al. Characterization of Distinct Immunophenotypes across Pediatric Brain Tumor Types , 2013, The Journal of Immunology.
[163] J. Khan,et al. Targeting Wild-Type and Mutationally Activated FGFR4 in Rhabdomyosarcoma with the Inhibitor Ponatinib (AP24534) , 2013, PloS one.
[164] Ricardo Araya,et al. Results: pilot study , 2013 .
[165] Dongfang Li,et al. Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance , 2013, Nature Genetics.
[166] David T. W. Jones,et al. Signatures of mutational processes in human cancer , 2013, Nature.
[167] Roland Eils,et al. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma , 2013, Nature Genetics.
[168] Liliana Goumnerova,et al. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1 , 2013, Proceedings of the National Academy of Sciences.
[169] Heather L. Mulder,et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas , 2013, Nature Genetics.
[170] Peter Houghton,et al. A Proposal Regarding Reporting of In Vitro Testing Results , 2013, Clinical Cancer Research.
[171] W. Lam,et al. Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. , 2013, The Lancet. Oncology.
[172] K. Stegmaier,et al. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. , 2013, Cancer discovery.
[173] J. Tabernero,et al. Development of PI3K inhibitors: lessons learned from early clinical trials , 2013, Nature Reviews Clinical Oncology.
[174] Sridhar Ramaswamy,et al. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells , 2012, Nucleic Acids Res..
[175] J. Barnholtz-Sloan,et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. , 2012, Neuro-oncology.
[176] Sven Diederichs,et al. The hallmarks of cancer , 2012, RNA biology.
[177] J. Squire,et al. The Genetics of Osteosarcoma , 2012, Sarcoma.
[178] Drew M. Pardoll,et al. The blockade of immune checkpoints in cancer immunotherapy , 2012, Nature Reviews Cancer.
[179] Jinghui Zhang,et al. Association of age at diagnosis and genetic mutations in patients with neuroblastoma. , 2012, JAMA.
[180] O. Delattre,et al. A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion , 2012, Nature Genetics.
[181] D. Zwijnenburg,et al. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes , 2012, Nature.
[182] David T. W. Jones,et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma , 2012, Nature.
[183] Li Ding,et al. Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas , 2012, Nature Genetics.
[184] A. Fojo,et al. Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale , 2012, Clinical Cancer Research.
[185] D. Gisselsson,et al. Copy number defects of G1‐Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis , 2012, Genes, chromosomes & cancer.
[186] Scott L. Pomeroy,et al. Molecular subgroups of medulloblastoma: the current consensus , 2011, Acta Neuropathologica.
[187] Matthew W. Wilson,et al. A Novel Retinoblastoma Therapy from Genomic and Epigenetic Analyses , 2011, Nature.
[188] P. Houghton,et al. The Anti-CD19 Antibody–Drug Conjugate SAR3419 Prevents Hematolymphoid Relapse Postinduction Therapy in Preclinical Models of Pediatric Acute Lymphoblastic Leukemia , 2011, Clinical Cancer Research.
[189] R. Siebert,et al. Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression. , 2011, The American journal of surgical pathology.
[190] F. Westermann,et al. High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma , 2011, Clinical Cancer Research.
[191] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[192] A. Byars,et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. , 2010, The New England journal of medicine.
[193] R. Siebert,et al. Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome. , 2010, American journal of human genetics.
[194] S. Keir,et al. Stage 2 Combination Testing of Rapamycin with Cytotoxic Agents by the Pediatric Preclinical Testing Program , 2010, Molecular Cancer Therapeutics.
[195] R. McLendon,et al. IDH1 and IDH2 mutations in gliomas. , 2009, The New England journal of medicine.
[196] H. Tanke,et al. The NFATc2 Gene Is Involved in a Novel Cloned Translocation in a Ewing Sarcoma Variant That Couples Its Function in Immunology to Oncology , 2009, Clinical Cancer Research.
[197] O. Witt,et al. Targeting histone deacetylases in neuroblastoma. , 2009, Current pharmaceutical design.
[198] John M. Maris,et al. Identification of ALK as a major familial neuroblastoma predisposition gene , 2008, Nature.
[199] Gudrun Schleiermacher,et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma , 2008, Nature.
[200] S. Spunt,et al. Pediatric nonrhabdomyosarcoma soft tissue sarcomas. , 2008, The oncologist.
[201] J. Ross,et al. Trends in childhood cancer incidence in the U.S. (1992–2004) , 2008, Cancer.
[202] A. Feinberg,et al. An X Chromosome Gene, WTX, Is Commonly Inactivated in Wilms Tumor , 2007, Science.
[203] Michael A. Dyer,et al. Inactivation of the p53 pathway in retinoblastoma , 2006, Nature.
[204] N. Rahman,et al. Surveillance for Wilms tumour in at-risk children: pragmatic recommendations for best practice , 2006, Archives of Disease in Childhood.
[205] H. Aburatani,et al. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. , 2006, Human molecular genetics.
[206] P. Lichter,et al. Detection of chromosomal imbalances in retinoblastoma by matrix‐based comparative genomic hybridization , 2005, Genes, chromosomes & cancer.
[207] W. Rose,et al. Therapeutic Synergy of Oral Taxane BMS-275183 and Cetuximab versus Human Tumor Xenografts , 2004, Clinical Cancer Research.
[208] P. Marks,et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[209] Barbara Hero,et al. Neuroblastoma: biology and molecular and chromosomal pathology. , 2003, The Lancet. Oncology.
[210] Alfons Meindl,et al. The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25 , 2001, Oncogene.
[211] P. Houghton,et al. Direct translation of a protracted irinotecan schedule from a xenograft model to a phase I trial in children. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[212] Olivier Delattre,et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer , 1998, Nature.
[213] P. Sorensen,et al. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma , 1998, Nature Genetics.
[214] M. Greaves. Aetiology of acute leukaemia , 1997, The Lancet.
[215] C. Cooper,et al. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma , 1994, Nature Genetics.
[216] W. Gerald,et al. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. , 1994, Cancer research.
[217] P. Sorensen,et al. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG , 1994, Nature Genetics.
[218] J. Downing,et al. Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. , 1993, Cancer research.
[219] B. Emanuel,et al. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma , 1993, Nature Genetics.
[220] N. Mandahl,et al. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma , 1993, Nature.
[221] G. Thomas,et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours , 1992, Nature.
[222] C. Shields,et al. Retinoblastoma , 1992, Nature Reviews Disease Primers.
[223] B. Gallie,et al. Identification of germline and somatic mutations affecting the retinoblastoma gene. , 1988, Science.
[224] N. Copeland,et al. Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism , 1985, Nature.
[225] Pembrolizumab Approved for Hodgkin Lymphoma. , 2017, Cancer discovery.
[226] Jerad M. Gardner,et al. Ewing sarcoma. , 2014, Seminars in diagnostic pathology.
[227] J. Stockman,et al. Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis , 2012 .
[228] A. Alavi,et al. Opportunities and Challenges , 1998, In Vitro Diagnostic Industry in China.
[229] Ashton C. Berger,et al. "Lineage addiction" in human cancer: lessons from integrated genomics. , 2005, Cold Spring Harbor symposia on quantitative biology.