Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.
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J. Downward | M. Sudol | S. Basu | N. Totty | M. Irwin
[1] P. Hornbeck,et al. Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs* , 2002, The Journal of Biological Chemistry.
[2] J. Downward,et al. The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif* , 2002, The Journal of Biological Chemistry.
[3] B. Pützer,et al. p73 in apoptosis , 2001, Apoptosis.
[4] E. Rosen,et al. Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage. , 2001, Cancer research.
[5] Yong Liao,et al. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation , 2001, Nature Cell Biology.
[6] B. Hemmings,et al. Ten years of protein kinase B signalling: a hard Akt to follow. , 2001, Trends in biochemical sciences.
[7] Xin Lu,et al. ASPP proteins specifically stimulate the apoptotic function of p53. , 2001, Molecular cell.
[8] J. Woodgett,et al. PKB/AKT: functional insights from genetic models , 2001, Nature Reviews Molecular Cell Biology.
[9] L. Mayo,et al. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[10] T. Tuschl,et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.
[11] M. DePamphilis,et al. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. , 2001, Genes & development.
[12] L. Castagnoli,et al. Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity* , 2001, The Journal of Biological Chemistry.
[13] M. Sudol,et al. Yes-associated Protein and p53-binding Protein-2 Interact through Their WW and SH3 Domains* , 2001, The Journal of Biological Chemistry.
[14] G. Blandino,et al. From p63 to p53 across p73 , 2001, FEBS letters.
[15] M. Yaffe,et al. TAZ: a novel transcriptional co‐activator regulated by interactions with 14‐3‐3 and PDZ domain proteins , 2000, The EMBO journal.
[16] Toshiyuki Obata,et al. Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB* , 2000, The Journal of Biological Chemistry.
[17] M. Sudol,et al. Yes-Associated Protein 65 Localizes P62c-Yes to the Apical Compartment of Airway Epithelia by Association with Ebp50 , 1999, The Journal of cell biology.
[18] S. R. Datta,et al. Cellular survival: a play in three Akts. , 1999, Genes & development.
[19] B. Séraphin,et al. A generic protein purification method for protein complex characterization and proteome exploration , 1999, Nature Biotechnology.
[20] Jijie Gu,et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage , 1999, Nature.
[21] Antonio Costanzo,et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage , 1999, Nature.
[22] J. Downward,et al. Role of Phosphoinositide 3-Kinase in Activation of Ras and Mitogen-Activated Protein Kinase by Epidermal Growth Factor , 1999, Molecular and Cellular Biology.
[23] Lin-Feng Chen,et al. A WW domain‐containing Yes‐associated protein (YAP) is a novel transcriptional co‐activator , 1999, The EMBO journal.
[24] Julian Downward,et al. Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell–matrix and cell–cell interaction , 1999, Current Biology.
[25] Geert J. P. L. Kops,et al. Direct control of the Forkhead transcription factor AFX by protein kinase B , 1999, Nature.
[26] M. Greenberg,et al. Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.
[27] A. Giaccia,et al. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. , 1998, Genes & development.
[28] M. Birnbaum,et al. Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt* , 1998, The Journal of Biological Chemistry.
[29] C. Harley,et al. Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.
[30] M. Yaffe,et al. The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity , 1997, Cell.
[31] L. Peso,et al. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.
[32] S. R. Datta,et al. Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.
[33] Asim Khwaja,et al. Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway , 1997, The EMBO journal.
[34] P. Cohen,et al. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase , 1996, FEBS letters.
[35] P. Cohen,et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.
[36] P. Bork,et al. Characterization of the Mammalian YAP (Yes-associated Protein) Gene and Its Role in Defining a Novel Protein Module, the WW Domain (*) , 1995, The Journal of Biological Chemistry.
[37] M. Sudol,et al. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. , 1994, Oncogene.
[38] K Y Hui,et al. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). , 1994, The Journal of biological chemistry.
[39] N. Nonomura,et al. Loss of p73 induction in a cisplatin-resistant bladder cancer cell line. , 2001, Molecular urology.
[40] Xu-Rong Jiang,et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype , 1999, Nature Genetics.