论文信息 - Glycosidic Flavonoids as Rat-Liver Injury Preventing Compounds from Green Tea

Glycosidic Flavonoids as Rat-Liver Injury Preventing Compounds from Green Tea

A glycosidic flavonoids-rich fraction from green tea leaves was purified to isolate five glycosidic flavonoids, guided by the detection of a preventive effect on D-galactosamine-induced liver injury in rats. These were identified as a flavone C-glycoside (1) and trisaccharide flavonols (2-5) based on the spectroscopic analyses. These compounds suppressed the D-galactosamine-induced increase of plasma alanine aminotransferase and asparatate aminotransferase activities in rats.

[1] T. Mabry,et al. C-galactosylflavones from Polygonatum multiflorum , 1977 .

[2] D. Segerbäck,et al. Chemical Studies on Bryophytes. 22. Flavonoid C-Glycosides of Mnium undulatum. , 1979 .

[3] N. Watanabe,et al. Hepatoprotective compounds from Canarium album and Euphorbia nematocypha. , 1990, Chemical & pharmaceutical bulletin.

[4] V. Wray,et al. Flavonol glycosides in teakaempferol and quercetin rhamnodiglucosides , 1991 .

[5] S. Iwasaki,et al. Two flavonol glycosides from seeds of Camellia sinensis. , 1991, Phytochemistry.

[6] V. Wray,et al. Flavonol triglycosides containing galactose in tea. , 1991, Phytochemistry.

[7] P. He,et al. Green tea suppresses D-galactosamine-induced liver injury in rats. , 1998, Bioscience, biotechnology, and biochemistry.

[8] P. He,et al. Suppression of D-galactosamine-induced rat liver injury by glycosidic flavonoids-rich fraction from green tea. , 1999, Bioscience, biotechnology, and biochemistry.

[9] N. Watanabe,et al. Liver injury-preventive effect of tea theanine in rats , 2000 .