FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds.

[1]  J. Milaire.  A new interpretation of the necrotic changes occurring in the developing limb bud paddle of mouse embryos based upon recent observations in four different phenotypes. , 1992, The International journal of developmental biology.

[2]  C. Tabin,et al.  Sonic hedgehog mediates the polarizing activity of the ZPA , 1993, Cell.

[3]  C. Tickle,et al.  A positive feedback loop coordinates growth and patterning in the vertebrate limb , 1994, Nature.

[4]  M. Landry,et al.  Conversion of anterior limb bud cells to ZPA signaling cells in vitro and in vivo. , 1994, Developmental biology.

[5]  C. Tabin,et al.  Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud , 1994, Cell.

[6]  D. Monté,et al.  Molecular characterization of the ets-related human transcription factor ER81. , 1995, Oncogene.

[7]  M. Magnuson,et al.  Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. , 1997, Development.

[8]  B. Hogan,et al.  Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. , 1997, Developmental biology.

[9]  R. Balling,et al.  Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation , 1997, Cell.

[10]  A. Bloch-Zupan,et al.  The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome. , 1998, Human molecular genetics.

[11]  E. S. Hunter,et al.  Apoptosis and morphology in mouse embryos by confocal laser scanning microscopy. , 1999, Methods.

[12]  E. Olson,et al.  The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. , 2000, Development.

[13]  C. Tickle,et al.  Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. , 2000, Development.

[14]  I. S. Kathiriya,et al.  Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. , 2000, Development.

[15]  M. Rudnicki,et al.  Male Sexual Dysfunction in Mice Bearing Targeted Mutant Alleles of the PEA3 ets Gene , 2000, Molecular and Cellular Biology.

[16]  P. Kraus,et al.  Some distal limb structures develop in mice lacking Sonic hedgehog signaling , 2001, Mechanisms of Development.

[17]  P. Beachy,et al.  Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. , 2001, Developmental biology.

[18]  R. Zeller,et al.  Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. , 2002, Genes & development.

[19]  C. Deng,et al.  Generation of Fgfr1 conditional knockout mice , 2002, Genesis.

[20]  Vincenzo De Paola,et al.  ETS Gene Pea3 Controls the Central Position and Terminal Arborization of Specific Motor Neuron Pools , 2002, Neuron.

[21]  G. Martin,et al.  Functions of FGF signalling from the apical ectodermal ridge in limb development , 2002, Nature.

[22]  C. Tabin,et al.  Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer , 2002, Genesis.

[23]  C. Deng,et al.  Generation of Fgfr1 conditional knockout mice , 2002 .

[24]  Rolf Zeller,et al.  Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3 , 2002, Science.

[25]  M. Pines,et al.  The IIIc alternative of Fgfr2 is a positive regulator of bone formation. , 2002, Development.

[26]  L. Niswander.  Interplay between the molecular signals that control vertebrate limb development. , 2002, The International journal of developmental biology.

[27]  Yina Li,et al.  Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity , 2002, Nature.

[28]  G. Martin,et al.  Deciphering skeletal patterning: clues from the limb , 2003, Nature.

[29]  Benjamin R. Arenkiel,et al.  The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. , 2004, Developmental biology.

[30]  D. Duboule,et al.  A Dual Role for Hox Genes in Limb Anterior-Posterior Asymmetry , 2004, Science.

[31]  Michael Tsang,et al.  Promotion and Attenuation of FGF Signaling Through the Ras-MAPK Pathway , 2004, Science's STKE.

[32]  Christof Niehrs,et al.  Fibroblast growth factor signaling during early vertebrate development. , 2005, Endocrine reviews.

[33]  S. Arber,et al.  ERM is required for transcriptional control of the spermatogonial stem cell niche , 2005, Nature.

[34]  V. Centonze,et al.  Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities , 2005, Nature Genetics.

[35]  M. Lewandoski,et al.  Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development , 2005, Development.

[36]  Jamie M. Verheyden,et al.  Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning , 2005, Development.

[37]  G. Martin,et al.  Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function , 2006, Development.

[38]  J. Hinchliffe,et al.  Birth and death of cells in limb development: A mapping study , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[39]  C. Tabin,et al.  Mechanistic insight into how Shh patterns the vertebrate limb. , 2006, Current opinion in genetics & development.

[40]  G. Martin,et al.  Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning , 2008, Nature.

[41]  Jianjian Zhu,et al.  Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. , 2008, Developmental cell.

[42]  D. Ornitz,et al.  FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis , 2008, Development.

[43]  Xin Sun,et al.  An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth , 2008, Nature.

[44]  C. Tickle,et al.  Integration of growth and specification in chick wing digit-patterning , 2008, Nature.

[45]  C. Tabin,et al.  Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. , 2009, Developmental cell.