Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation.

[1]  D. Mansuy,et al.  Hydroxylation of the thiophene ring by hepatic monooxygenases. Evidence for 5-hydroxylation of 2-aroylthiophenes as a general metabolic pathway using a simple UV-visible assay. , 1990, Biochemical pharmacology.

[2]  D. Mansuy,et al.  Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes. , 1990, Biochemical pharmacology.

[3]  U. Meyer,et al.  Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency. , 1987, Biochemistry.

[4]  U. Meyer,et al.  Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation. , 1986, Biochimica et biophysica acta.

[5]  T. Shimada,et al.  Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. , 1986, The Journal of biological chemistry.

[6]  Y. Mori,et al.  Further structural analysis of urinary metabolites of suprofen in the rat. , 1984, Drug metabolism and disposition: the biological fate of chemicals.

[7]  D. Mansuy,et al.  Metabolic hydroxylation of the thiophene ring: isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat. , 1984, Biochemical pharmacology.

[8]  N. Abuaf,et al.  A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis. , 1984, Clinical and experimental immunology.

[9]  P. Beaune,et al.  Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes. , 1983, Biochemistry.

[10]  H. Wallin,et al.  A rapid and sensitive method for determination of covalent binding of benzo[a]pyrene to proteins. , 1981, Chemico-biological interactions.

[11]  P. Beaune,et al.  Cytochrome P-450 monooxygenase activities in human and rat liver microsomes. , 1981, European journal of biochemistry.

[12]  M. Herbert,et al.  Synthese d'un diuretique marque au carbone 14: Acide dichloro‐2,3 [thenoyl‐2 (14C = 0)]‐4 phenoxy acetique (D.C.I. acide tiénilique) , 1976 .

[13]  H. G. Bray,et al.  The metabolism of thiophen in the rabbit and the rat. , 1971, Xenobiotica; the fate of foreign compounds in biological systems.

[14]  A. Fenselau Nicotinamide adenine dinucleotide as an active site director in glyceraldehyde 3-phosphate dehydrogenase modification. , 1970, The Journal of biological chemistry.

[15]  T. Omura,et al.  A new cytochrome in liver microsomes. , 1962, The Journal of biological chemistry.

[16]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[17]  M. J. Coon,et al.  The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. , 1989, DNA.

[18]  P. Beaune,et al.  Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[19]  M. Lynch,et al.  The in vitro and in vivo metabolism of morantel in cattle and toxicology species. , 1987, Drug metabolism reviews.

[20]  M. Tateishi,et al.  Metabolism of tenoxicam in rats. , 1984, Xenobiotica; the fate of foreign compounds in biological systems.