Association of Childhood Oral Infections With Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood

Key Points Question Are childhood oral infections or inflammatory conditions associated with the risk of adulthood subclinical atherosclerosis? Findings In this cohort study of 755 participants followed up for 27 years into adulthood, a number of clinical signs of oral infections in childhood were associated with both cumulative exposure to cardiovascular risk factors during the follow-up and subclinical atherosclerosis in adulthood. Meaning Childhood oral infections may be a modifiable risk factor for adult cardiovascular disease.

[1]  P. Pussinen,et al.  Mediators between oral dysbiosis and cardiovascular diseases , 2018, European journal of oral sciences.

[2]  T. Laitinen,et al.  Childhood socioeconomic status and lifetime health behaviors: The Young Finns Study. , 2018, International journal of cardiology.

[3]  A. Nordblad,et al.  Dental and periodontal health in Finnish adults in 2000 and 2011 , 2018, Acta odontologica Scandinavica.

[4]  Tyler J. VanderWeele,et al.  Sensitivity Analysis in Observational Research: Introducing the E-Value , 2017, Annals of Internal Medicine.

[5]  T. Lehtimäki,et al.  Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance: The Young Finns Study. , 2017, Journal of the American College of Cardiology.

[6]  D. Jacobs,et al.  The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study , 2017, Journal of clinical periodontology.

[7]  H. Becher,et al.  Association between infectious burden, socioeconomic status, and ischemic stroke. , 2016, Atherosclerosis.

[8]  J. Sinisalo,et al.  Association of Endodontic Lesions with Coronary Artery Disease , 2016, Journal of dental research.

[9]  Jun Wang,et al.  Metagenome-wide association studies: fine-mining the microbiome , 2016, Nature Reviews Microbiology.

[10]  T. Lehtimäki,et al.  Childhood Infections, Socioeconomic Status, and Adult Cardiometabolic Risk , 2016, Pediatrics.

[11]  D. Maahs,et al.  Periodontal Microorganisms and Cardiovascular Risk Markers in Youth With Type 1 Diabetes and Without Diabetes. , 2016, Journal of periodontology.

[12]  B. D. de Mol,et al.  Infections in early life and premature acute coronary syndrome: A case-control study , 2016, European journal of preventive cardiology.

[13]  Tamotsu Kato,et al.  Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver , 2015, PloS one.

[14]  J. Viikari,et al.  Lifetime measures of ideal cardiovascular health and their association with subclinical atherosclerosis: The Cardiovascular Risk in Young Finns Study. , 2015, International journal of cardiology.

[15]  T. Lehtimäki,et al.  Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: the Cardiovascular Risk in Young Finns Study. , 2015, Atherosclerosis.

[16]  C. Marcus,et al.  Pathological periodontal pockets are associated with raised diastolic blood pressure in obese adolescents , 2015, BMC oral health.

[17]  K. Froberg,et al.  Association between body mass index and caries among children and adolescents. , 2014, Community dentistry and oral epidemiology.

[18]  D. E. Slot,et al.  Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. , 2014, Journal of clinical periodontology.

[19]  R. Sacco,et al.  Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima‐Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study , 2013, Journal of the American Heart Association.

[20]  M. Järvelin,et al.  Geographical Distribution of Dental Caries Prevalence and Associated Factors in Young Adults in Finland , 2013, Caries Research.

[21]  Christiane,et al.  World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. , 2013, JAMA.

[22]  J. Ebersole,et al.  The potential lifespan impact of gingivitis and periodontitis in children. , 2013, The Journal of clinical pediatric dentistry.

[23]  Panos N Papapanou,et al.  Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association?: a scientific statement from the American Heart Association. , 2012, Circulation.

[24]  W. Osika,et al.  Age- and sex-related differences in vascular function and vascular response to mental stress. Longitudinal and cross-sectional studies in a cohort of healthy children and adolescents. , 2012, Atherosclerosis.

[25]  R. Volkmann,et al.  Sex differences in peripheral artery intima, media and intima media thickness in children and adolescents. , 2008, Atherosclerosis.

[26]  Risto Telama,et al.  Cohort profile: the cardiovascular risk in Young Finns Study. , 2008, International journal of epidemiology.

[27]  H. Ohlin,et al.  Dual role of infections as risk factors for coronary heart disease. , 2007, Atherosclerosis.

[28]  J. Viikari,et al.  Increased Aortic Intima-Media Thickness in 11-Year-Old Healthy Children With Persistent Chlamydia pneumoniae Seropositivity , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[29]  T. Laitinen,et al.  Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. , 2003, JAMA.

[30]  S. Ylä-Herttuala,et al.  Acute infections in children are accompanied by oxidative modification of LDL and decrease of HDL cholesterol, and are followed by thickening of carotid intima-media. , 2003, European heart journal.

[31]  Wolzt,et al.  World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. , 2003, The Journal of the American College of Dentists.

[32]  R. Page,et al.  Risk assessment for periodontal diseases. , 1997, International dental journal.

[33]  G. Hallmans,et al.  Relationship between dental caries and risk factors for atherosclerosis in Swedish adolescents? , 1995, Community dentistry and oral epidemiology.