Molecular characterization of the tumor microenvironment in breast cancer.

[1]  S. Barsky,et al.  The myoepithelial defense: a host defense against cancer. , 1997, Medical hypotheses.

[2]  David E. Misek,et al.  Analysis of Tumor-Host Interactions by Gene Expression Profiling of Lung Adenocarcinoma Xenografts Identifies Genes Involved in Tumor Formation , 2005, Molecular Cancer Research.

[3]  K. Korach,et al.  Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. , 2003, Molecular endocrinology.

[4]  M J Bissell,et al.  Tumors are unique organs defined by abnormal signaling and context. , 2001, Seminars in cancer biology.

[5]  Mina J Bissell,et al.  The organizing principle: microenvironmental influences in the normal and malignant breast. , 2002, Differentiation; research in biological diversity.

[6]  A. Otaka,et al.  T140 analogs as CXCR4 antagonists identified as anti‐metastatic agents in the treatment of breast cancer , 2003, FEBS letters.

[7]  R. Callahan Genetic alterations in primary breast cancer , 1989, Breast Cancer Research and Treatment.

[8]  K. Kinzler,et al.  Genes expressed in human tumor endothelium. , 2000, Science.

[9]  Cheng Li,et al.  dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data , 2004, Bioinform..

[10]  P. Piccioli,et al.  Expression of the Chemokine Receptor CXCR4 and Its Ligand Stromal Cell‐Derived Factor 1 in Human Brain Tumors and Their Involvement in Glial Proliferation in Vitro , 2002, Annals of the New York Academy of Sciences.

[11]  M. Shekhar,et al.  Host microenvironment in breast cancer development: Extracellular matrix–stromal cell contribution to neoplastic phenotype of epithelial cells in the breast , 2003, Breast Cancer Research.

[12]  Hermann Herbst,et al.  Common Adult Stem Cells in the Human Breast Give Rise to Glandular and Myoepithelial Cell Lineages: A New Cell Biological Concept , 2002, Laboratory Investigation.

[13]  Andrew L Kung,et al.  A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[14]  A. Zlotnik,et al.  The biology of chemokines and their receptors. , 2000, Annual review of immunology.

[15]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[16]  R. Ádány,et al.  Hypomethylation of the decorin proteoglycan gene in human colon cancer. , 1991, The Biochemical journal.

[17]  Olivier De Wever,et al.  Role of tissue stroma in cancer cell invasion , 2003, The Journal of pathology.

[18]  Ana M Soto,et al.  The stroma as a crucial target in rat mammary gland carcinogenesis , 2004, Journal of Cell Science.

[19]  S. Devries,et al.  Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences. , 2000, Journal of the National Cancer Institute.

[20]  T. Ochiya,et al.  Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. , 2003, Biochemical and biophysical research communications.

[21]  Andy J. Minn,et al.  Genes that mediate breast cancer metastasis to lung , 2005, Nature.

[22]  R. Tibshirani,et al.  Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[23]  H. Berman,et al.  Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis. , 2005, Cold Spring Harbor symposia on quantitative biology.

[24]  Cynthia A Afshari,et al.  Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. , 2004, Cancer cell.

[25]  Sanford H Barsky,et al.  Myoepithelial mRNA expression profiling reveals a common tumor-suppressor phenotype. , 2003, Experimental and molecular pathology.

[26]  C. Plass,et al.  Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors , 2005, British Journal of Cancer.

[27]  B. Teicher,et al.  Myofibroblasts enable invasion of endothelial cells into three-dimensional tumor cell clusters: a novel in vitro tumor model , 2003, Cancer Chemotherapy and Pharmacology.

[28]  Xiaobing Fu,et al.  Analysis of differentially expressed genes in keloids and normal skin with cDNA microarray. , 2003, The Journal of surgical research.

[29]  I. Kurth,et al.  Monocyte Selectivity and Tissue Localization Suggests a Role for Breast and Kidney–Expressed Chemokine (Brak) in Macrophage Development , 2001, The Journal of experimental medicine.

[30]  G. Stamatoyannopoulos,et al.  Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. , 2003, Cancer research.

[31]  Ronald W. Davis,et al.  Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray , 1995, Science.

[32]  G. Gabbiani Some historical and philosophical reflections on the myofibroblast concept. , 1999, Current topics in pathology. Ergebnisse der Pathologie.

[33]  John R Yates,et al.  Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  G. Bratthauer,et al.  Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. , 2000, Cancer research.

[35]  Satoshi Matsumoto,et al.  Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas , 2002, Nature Genetics.

[36]  P. Leder,et al.  The kit ligand: A cell surface molecule altered in steel mutant fibroblasts , 1990, Cell.

[37]  T. Tlsty,et al.  Know thy neighbor: stromal cells can contribute oncogenic signals. , 2001, Current opinion in genetics & development.

[38]  B. Fingleton,et al.  Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. , 2004, Cancer cell.

[39]  Jing Huang,et al.  Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array. , 2004, Genome research.

[40]  J. Pringle,et al.  There is more than one kind of myofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions , 2003, Journal of clinical pathology.

[41]  J. Marks,et al.  A SAGE (serial analysis of gene expression) view of breast tumor progression. , 2001, Cancer research.

[42]  B. Unsworth,et al.  Breast Cancer: Induction of Differentiation by Embryonic Tissue , 1973, Science.

[43]  M J O'Hare,et al.  Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. Kidron,et al.  Application of comparative genomic hybridization in search for genetic aberrations in fibroadenomas of the breast. , 2003, Cancer genetics and cytogenetics.

[45]  G. Cunha,et al.  Mesenchymal reprogramming of adult human epithelial differentiation. , 1999, Differentiation; research in biological diversity.

[46]  C. Eng,et al.  Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation. , 2006, American journal of human genetics.

[47]  S. Barsky,et al.  Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells. , 2000, Experimental cell research.

[48]  J. Garlick,et al.  Cell interactions control the fate of malignant keratinocytes in an organotypic model of early neoplasia. , 1999, The Journal of investigative dermatology.

[49]  M J Bissell,et al.  Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. , 1996, Physiological reviews.

[50]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[51]  Ash A. Alizadeh,et al.  Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays , 1999, Nature Genetics.

[52]  Mina J Bissell,et al.  Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. , 2010, Journal of cell science.

[53]  H. Dvorak Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. , 1986, The New England journal of medicine.

[54]  Martin A. Nowak,et al.  The significance of unstable chromosomes in colorectal cancer , 2003, Nature Reviews Cancer.

[55]  Jun S. Liu,et al.  Clustering analysis of SAGE data using a Poisson approach , 2004, Genome Biology.

[56]  C. Cordon-Cardo,et al.  A multigenic program mediating breast cancer metastasis to bone. , 2003, Cancer cell.

[57]  K. Chew,et al.  p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. , 2005, Cancer research.

[58]  S. Barsky,et al.  The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype , 2000, Oncogene.

[59]  Z. Shao,et al.  The human myoepithelial cell exerts antiproliferative effects on breast carcinoma cells characterized by p21WAF1/CIP1 induction, G2/M arrest, and apoptosis. , 1998, Experimental cell research.

[60]  M. Bissell,et al.  The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells. , 1995, The Journal of clinical investigation.

[61]  K. Hemminki,et al.  Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer. , 2001, European journal of cancer.

[62]  J. Foekens,et al.  Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer , 2005, The Lancet.

[63]  A. Thor,et al.  Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas , 1996, Science.

[64]  E. Lander,et al.  A molecular signature of metastasis in primary solid tumors , 2003, Nature Genetics.

[65]  R. Weinberg,et al.  Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. , 2001, Experimental cell research.

[66]  Anthony J. Guidi,et al.  Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[67]  K. Chew,et al.  Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. , 2003, Cancer research.

[68]  J. Sebat,et al.  Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. , 2003, Genome research.

[69]  K. Hunter,et al.  Host genetics and tumour metastasis , 2004, British Journal of Cancer.

[70]  Mina J Bissell,et al.  Tumor reversion: Correction of malignant behavior by microenvironmental cues , 2003, International journal of cancer.

[71]  Ash A. Alizadeh,et al.  Genome-wide analysis of DNA copy-number changes using cDNA microarrays , 1999, Nature Genetics.

[72]  J. Thiery,et al.  The importance of being a myoepithelial cell , 2002, Breast Cancer Research.

[73]  W. Schürch The myofibroblast in neoplasia. , 1999, Current topics in pathology. Ergebnisse der Pathologie.

[74]  K. Sano,et al.  Inhibition of induction of myofibroblasts by interferon γ in a human fibroblast cell line , 2003 .

[75]  R. Coombes,et al.  A paracrine role for myoepithelial cell-derived FGF2 in the normal human breast. , 1997, Experimental cell research.

[76]  L. Coussens,et al.  Inflammation and cancer , 2002, Nature.

[77]  S. Frisch,et al.  Disruption of epithelial cell-matrix interactions induces apoptosis , 1994, The Journal of cell biology.

[78]  Cheng Li,et al.  Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate cancer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformatics platform dChipSNP. , 2003, Cancer research.

[79]  A. Sahin,et al.  In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. , 2000, The American journal of pathology.

[80]  A. Wellmann,et al.  Presence of genetic alterations in microdissected stroma of human colon and breast cancers. , 2001, Journal of molecular medicine.

[81]  Zena Werb,et al.  Stromal Effects on Mammary Gland Development and Breast Cancer , 2002, Science.

[82]  E. Lander,et al.  Construction of multilocus genetic linkage maps in humans. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[83]  Mina J. Bissell,et al.  Putting tumours in context , 2001, Nature Reviews Cancer.

[84]  T. Hsu,et al.  Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[85]  Jun Yao,et al.  Distinct epigenetic changes in the stromal cells of breast cancers , 2005, Nature Genetics.

[86]  L. Chin,et al.  High-Resolution Global Profiling of Genomic Alterations with Long Oligonucleotide Microarray , 2004, Cancer Research.

[87]  I. Ellis,et al.  Molecular analysis of phyllodes tumors reveals distinct changes in the epithelial and stromal components. , 2000, The American journal of pathology.

[88]  Yudong D. He,et al.  A Gene-Expression Signature as a Predictor of Survival in Breast Cancer , 2002 .

[89]  S. Lemeshow,et al.  Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions. , 2001, Human molecular genetics.

[90]  M. Stratton,et al.  Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations. , 1998, Journal of the National Cancer Institute.

[91]  Dennis C. Sgroi,et al.  Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion , 2005, Cell.

[92]  H. Kurz,et al.  Platelet-derived growth factor-B induces transformation of fibrocytes into spindle-shaped myofibroblasts in vivo , 1998, Histochemistry and Cell Biology.

[93]  J. Foidart,et al.  Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts. , 1993, British Journal of Cancer.

[94]  Takafumi Nishizaki,et al.  Genetic alterations in primary breast cancers and their metastases: Direct comparison using modified comparative genomic hybridization , 1997, Genes, chromosomes & cancer.

[95]  R. D'Amato,et al.  Genetic heterogeneity of angiogenesis in mice , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[96]  J. Ni,et al.  Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[97]  Z. Shao,et al.  The human myoepithelial cell is a natural tumor suppressor. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

[98]  Gordon Stamp,et al.  Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. , 2002, Cancer research.

[99]  M. Stratton,et al.  Genetic alterations in ‘normal’ luminal and myoepithelial cells of the breast , 1999, The Journal of pathology.

[100]  T. Tlsty,et al.  Stromal cells can contribute oncogenic signals. , 2001, Seminars in cancer biology.

[101]  B. Rollins,et al.  Chemokines and disease , 2001, Nature Immunology.

[102]  G. Bratthauer,et al.  A subset of morphologically distinct mammary myoepithelial cells lacks corresponding immunophenotypic markers , 2003, Breast Cancer Research.

[103]  M. Washington,et al.  TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia , 2004, Science.

[104]  G. Dontu,et al.  In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. , 2003, Genes & development.

[105]  I. Ellis,et al.  The Wnt pathway, epithelial–stromal interactions, and malignant progression in phyllodes tumours , 2002, The Journal of pathology.

[106]  Russell Vang,et al.  Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion , 2003, Breast Cancer Research.

[107]  T. Murrell,et al.  The potential for oxytocin (OT) to prevent breast cancer: a hypothesis , 1995, Breast Cancer Research and Treatment.

[108]  Tatjana Crnogorac-Jurcevic,et al.  Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer , 2003, Oncogene.

[109]  C. Morrison,et al.  Combined Total Genome Loss of Heterozygosity Scan of Breast Cancer Stroma and Epithelium Reveals Multiplicity of Stromal Targets , 2004, Cancer Research.

[110]  H. Nakshatri,et al.  Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. , 1999, Biochemical and biophysical research communications.

[111]  S. Rafii,et al.  VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche , 2005, Nature.

[112]  Kornelia Polyak,et al.  Molecular markers in ductal carcinoma in situ of the breast. , 2003, Molecular cancer research : MCR.

[113]  M. Goggins,et al.  Gene Expression Profiling of Tumor–Stromal Interactions between Pancreatic Cancer Cells and Stromal Fibroblasts , 2004, Cancer Research.

[114]  R. Coombes,et al.  Separated human breast epithelial and myoepithelial cells have different growth factor requirements in vitro but can reconstitute normal breast lobuloalveolar structure , 1997, Journal of cellular physiology.

[115]  B. Unsworth,et al.  Embryonic inductive tissues that cause histologic differentiation of murine mammary carcinoma in vitro. , 1975, Journal of the National Cancer Institute.

[116]  R. Ádány,et al.  Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels. , 1990, The Journal of biological chemistry.

[117]  M J Bissell,et al.  The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. , 1996, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[118]  J. Watson,et al.  B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR α-chemokine , 2000 .

[119]  D. Piwnica-Worms,et al.  CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer , 2004, Cancer Research.

[120]  Jennifer Chan,et al.  A neural survival factor is a candidate oncogene in breast cancer , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[121]  H. Moses,et al.  Conditional inactivation of the TGF‐β type II receptor using Cre:Lox , 2002, Genesis.

[122]  R. Ádány,et al.  Altered methylation of versican proteoglycan gene in human colon carcinoma. , 1990, Biochemical and biophysical research communications.

[123]  S. Hayward,et al.  Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks , 2005, Oncogene.