论文信息 - False perception of visual verticality in multiple sclerosis

False perception of visual verticality in multiple sclerosis

We wanted to investigate to what extent patients with multiple sclerosis (MS), not complaining of dizziness or disequilibrium, may have problems with the estimation of gravidity. Therefore, we studied the static ‘subjective visual vertical’ (SVV), a test that is thought to reflect mainly otolith function. Further, we correlated SVV measures with the degree of disease disability. A group of outpatients was compared with a group of age‐ and sex‐matched healthy volunteers. The deviations of SVV in patients were significantly larger than in controls. Overall, SVV was abnormal in 48% of individual patients. There was a significant correlation between SVV and the global disability score. The same held true for correlation with the subscores of brainstem and cerebellar complaints. The SVV test proved to be a simple method that was well tolerated by the patients. It can be considered a complementary otoneurological tool for evaluating MS patients. Further, these findings suggest that misperception of the verticality parallels the disability in MS patients.

[1] D. Caputo,et al. Vertigo and multiple sclerosis: aspects of differential diagnosis , 2001, Neurological Sciences.

[2] T. Brandt,et al. Vestibular syndromes in the roll plane: Topographic diagnosis from brainstem to cortex , 1994, Annals of neurology.

[3] T. Brandt,et al. Ocular torsion and tilt of subjective visual vertical are sensitive brainstem signs , 1993, Annals of neurology.

[4] Marousa Pavlou,et al. Effect of semicircular canal stimulation on the perception of the visual vertical. , 2003, Journal of neurophysiology.

[5] M. Versino,et al. Vestibular evoked myogenic potentials in multiple sclerosis patients , 2002, Clinical Neurophysiology.

[6] G. Friedmann. The judgement of the visual vertical and horizontal with peripheral and central vestibular lesions. , 1970, Brain : a journal of neurology.

[7] R. John Leigh,et al. Role of eye movement examination and subjective visual vertical in clinical evaluation of multiple sclerosis , 2003, Journal of Neurology.

[8] J. Kurtzke. Rating neurologic impairment in multiple sclerosis , 1983, Neurology.

[9] A. Compston,et al. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis , 2001, Annals of neurology.

[10] T. Brandt,et al. Ocular torsion and perceived vertical in oculomotor, trochlear and abducens nerve palsies. , 1993, Brain : a journal of neurology.