Pyrroloquinoline Quinone Slows Down the Progression of Osteoarthritis by Inhibiting Nitric Oxide Production and Metalloproteinase Synthesis

[1]  H. Weinans,et al.  Hsp90 inhibition protects against biomechanically induced osteoarthritis in rats. , 2013, Arthritis and rheumatism.

[2]  F. Morel,et al.  Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes , 2013, PloS one.

[3]  E. Papadimitriou,et al.  Subchondral cyst development and MMP-1 expression during progression of osteoarthritis: an immunohistochemical study. , 2013, Orthopaedics & traumatology, surgery & research : OTSR.

[4]  H. Im,et al.  MMP13 is a critical target gene during the progression of osteoarthritis , 2013, Arthritis Research & Therapy.

[5]  T. Ishii,et al.  Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-A(y) mice. , 2012, Biochemical and biophysical research communications.

[6]  T. Ishii,et al.  Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling. , 2012, Free radical biology & medicine.

[7]  S. Goldring,et al.  Osteoarthritis: a disease of the joint as an organ. , 2012, Arthritis and rheumatism.

[8]  Chun Cheng,et al.  The neuroprotective effect of pyrroloquinoline quinone on traumatic brain injury. , 2012, Journal of neurotrauma.

[9]  C. Beck,et al.  Establishment of an index with increased sensitivity for assessing murine arthritis , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[10]  J. Karliner,et al.  Altering Pyrroloquinoline Quinone Nutritional Status Modulates Mitochondrial, Lipid, and Energy Metabolism in Rats , 2011, PloS one.

[11]  Yoshiro Kobayashi The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation , 2010, Journal of leukocyte biology.

[12]  T. Shiomi,et al.  Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non‐neoplastic diseases , 2010, Pathology international.

[13]  M. Goldring,et al.  NF-kappaB signaling: multiple angles to target OA. , 2010, Current drug targets.

[14]  M. Daheshia,et al.  The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis , 2008, The Journal of Rheumatology.

[15]  J. Saklatvala Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis. , 2007, Current drug targets.

[16]  R. Rucker,et al.  Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat. , 2006, Biochimica et biophysica acta.

[17]  C. Lavalle,et al.  Do chondrocytes undergo "activation" and "transdifferentiation" during the pathogenesis of osteoarthritis? A review of the ultrastructural and immunohistochemical evidence. , 2006, Histology and histopathology.

[18]  R. Rucker,et al.  and Nutrient-Nutrient Interactions Pyrroloquinoline Quinone Modulates Mitochondrial Quantity and Function in Mice 1 , 2005 .

[19]  H. Roach,et al.  Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. , 2005, Arthritis and rheumatism.

[20]  C. Anthony,et al.  Biochemistry: Role of PQQ as a mammalian enzyme cofactor? , 2005, Nature.

[21]  R. Appleyard,et al.  Topical administration of the nitric oxide donor glyceryl trinitrate modifies the structural and biomechanical properties of ovine articular cartilage. , 2003, Osteoarthritis and cartilage.

[22]  P. Anderson,et al.  Pyrroloquinoline Quinone Improves Growth and Reproductive Performance in Mice Fed Chemically Defined Diets , 2003, Experimental biology and medicine.

[23]  J. Ju,et al.  ERK-1/2 and p38 Kinase Oppositely Regulate Nitric Oxide-induced Apoptosis of Chondrocytes in Association with p53, Caspase-3, and Differentiation Status* , 2002, The Journal of Biological Chemistry.

[24]  M. Goldring,et al.  The role of the chondrocyte in osteoarthritis. , 2000, Arthritis and rheumatism.

[25]  A. Mitchell,et al.  Physiological importance of quinoenzymes and the O-quinone family of cofactors. , 2000, The Journal of nutrition.

[26]  R. Borzì,et al.  Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. , 1998, Arthritis and rheumatism.

[27]  R. Rucker,et al.  Nutritional importance of pyrroloquinoline quinone. , 1989, Science.

[28]  O. Kennard,et al.  A novel coenzyme from bacterial primary alcohol dehydrogenases , 1979, Nature.

[29]  M. Goldring,et al.  NF-kappaB signaling: multiple angles to target OA. , 2010, Current drug targets.

[30]  C. Brinckerhoff,et al.  Matrix metalloproteinases: role in arthritis. , 2006, Frontiers in bioscience : a journal and virtual library.

[31]  E. Sato,et al.  Nitric oxide regulates mitochondrial respiration and functions of articular chondrocytes. , 2001, Arthritis and rheumatism.