Cyclic AMP and mechanisms of vasolidation

Cyclic AMP and the mechanism of vasodilation have been reviewed by first discussing the enzymes involved (adenyl cyclase, cyclic nucleotide phosphodiesterases, cyclic AMP-dependent protein kinase) and then agents that increase cAMP in smooth muscle. Two mechanisms of vasodilation are described: (i) effects on contractile proteins; (ii) effects on Ca2+ levels. Evidence for compartments of cAMP is also presented.

[1]  M. Blaustein.  Sodium/Calcium Exchange and the Control of Contractility in Cardiac Muscle and Vascular Smooth Muscle , 1988, Journal of cardiovascular pharmacology.

[2]  H. Hidaka,et al.  Selective inhibitors of three forms of cyclic nucleotide phosphodiesterases , 1984 .

[3]  Silver Pj.  Regulation of contractile activity in vascular smooth muscle by protein kinases. , 1985 .

[4]  G. Stiles,et al.  Adenosine receptors: clinical implications and biochemical mechanisms. , 1988, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

[5]  Takahiro Matsumoto,et al.  8‐Bromoguanosine 3′:5′‐cyclic monophosphate decreases intracellular free calcium concentrations in cultured vascular smooth muscle cells from rat aorta , 1987, FEBS letters.

[6]  P. Silver,et al.  Ca2+, calmodulin and cyclic AMP-dependent modulation of actin-myosin interactions in aorta. , 1981, Biochimica et biophysica acta.

[7]  C. Cooper,et al.  Cyclic AMP and the vascular action of parathyroid hormone. , 1986, Canadian journal of physiology and pharmacology.

[8]  W. Feniuk,et al.  Further characterization of the 5‐HT receptor mediating vascular relaxation and elevation of cyclic AMP in porcine isolated vena cava , 1989, British journal of pharmacology.

[9]  L. Iacopino,et al.  Vasoactive intestinal polypeptide-sensitive cyclic adenosine monophosphate generating system in the rat portal vein. , 1988, Archives internationales de pharmacodynamie et de therapie.

[10]  T. Lincoln,et al.  Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[11]  T. Lincoln,et al.  A comparison of the effects of forskolin and nitroprusside on cyclic nucleotides and relaxation in the rat aorta. , 1984, European journal of pharmacology.

[12]  L. Raeymaekers,et al.  Ca2+‐Transport ATPases of Vascular Smooth Muscle , 1988, Circulation research.

[13]  M. Shahid,et al.  Effects of forskolin on contractile responses and protein phosphorylation in the isolated perfused rat heart. , 1987, The Biochemical journal.

[14]  G. A. Charbon.  A rapid and selective vasodialtor effect of parathyroid hormone. , 1968, European journal of pharmacology.

[15]  R. Paul,et al.  Vascular Smooth Muscle: Calmodulin and Cyclic AMP‐Dependent Protein Kinase Alter Calcium Sensitivity in Porcine Carotid Skinned Fibers , 1982, Circulation research.

[16]  W. Linz,et al.  Effects of colforsin, trequinsin and isoprenaline on norepinephrine-induced contractions and cyclic nucleotide levels of isolated vascular tissue. , 1988, Arzneimittel-Forschung.

[17]  T. Lincoln,et al.  Cyclic GMP and mechanisms of vasodilation. , 1989, Pharmacology & therapeutics.

[18]  C. Lugnier,et al.  Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta. , 1986, Biochemical pharmacology.

[19]  L. Raeymaekers,et al.  Evidence for the presence of phospholamban in the endoplasmic reticulum of smooth muscle. , 1986, Biochimica et biophysica acta.

[20]  M. Uhler,et al.  Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches. , 1988, Recent progress in hormone research.

[21]  R. A. Murphy,et al.  Ca2+, crossbridge phosphorylation, and contraction. , 1989, Annual review of physiology.

[22]  R. Edwards,et al.  Comparison of the effects of fenoldopam, SK & F R-87516 and dopamine on renal arterioles in vitro. , 1986, European journal of pharmacology.

[23]  E. Krebs,et al.  Phosphorylation-dephosphorylation of enzymes. , 1979, Annual review of biochemistry.

[24]  C. Lugnier,et al.  Role of cyclic AMP- and cyclic GMP-phosphodiesterases in the control of cyclic nucleotide levels and smooth muscle tone in rat isolated aorta. A study with selective inhibitors. , 1987, Biochemical pharmacology.

[25]  T. Yanagisawa,et al.  Nitroglycerin relaxes canine coronary arterial smooth muscle without reducing intracellular Ca2+ concentrations measured with fura‐2 , 1989, British journal of pharmacology.

[26]  C. van Breemen,et al.  Cellular mechanisms regulating [Ca2+]i smooth muscle. , 1989, Annual review of physiology.

[27]  W. Feniuk,et al.  5-hydroxytryptamine-induced relaxation of neonatal porcine vena cava in vitro. , 1984, Life sciences.

[28]  J. Stull,et al.  The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. , 1985, Annual review of pharmacology and toxicology.

[29]  J. Corbin,et al.  Characterization and regulation of heart adenosine 3':5'-monophosphate-dependent protein kinase isozymes. , 1977, The Journal of biological chemistry.

[30]  Ram V. Sharma,et al.  Isolation of two myosin light-chain kinases from bovine carotid artery and their regulation by phosphorylation mediated by cyclic AMP-dependent protein kinase. , 1982, The Biochemical journal.

[31]  G. Johnson,et al.  The G-protein family and their interaction with receptors. , 1989, Endocrine reviews.

[32]  P. Silver,et al.  Adenosine-mediated relaxation and activation of cyclic AMP-dependent protein kinase in coronary arterial smooth muscle. , 1984, The Journal of pharmacology and experimental therapeutics.

[33]  L. Ignarro,et al.  Relaxation of bovine coronary arterial smooth muscle by cyclic GMP, cyclic AMP and analogs. , 1980, The Journal of pharmacology and experimental therapeutics.

[34]  J. Stull,et al.  The role of myosin light chain kinase phosphorylation in beta-adrenergic relaxation of tracheal smooth muscle. , 1983, Molecular pharmacology.

[35]  J. Lowenstein,et al.  Metabolic control of the circulation. Effects of acetate and pyruvate. , 1978, The Journal of clinical investigation.

[36]  R. Paul,et al.  Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP. , 1986, The American journal of physiology.

[37]  R. Loutzenhiser,et al.  Calcium Compartments and Mobilization During Contraction of Smooth Muscle , 1985 .

[38]  J. Beavo,et al.  Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets. , 1988, The Journal of biological chemistry.

[39]  C. Lugnier,et al.  Comparison of cyclic nucleotide phosphodiesterase isoforms from rat heart and bovine aorta. Separation and inhibition by selective reference phosphodiesterase inhibitors. , 1988, Biochemical pharmacology.

[40]  J. N. Wells,et al.  Effects of phosphodiesterase inhibitors on cyclic nucleotide levels and relaxation of pig coronary arteries. , 1979, Molecular pharmacology.

[41]  T. Clark,et al.  Vascular smooth muscle caldesmon. , 1986, The Journal of biological chemistry.

[42]  E. Bülbring,et al.  Catecholamine action on smooth muscle. , 1987, Pharmacological reviews.

[43]  Karaki Hideaki.  Ca2+ localization and sensitivity in vascular smooth muscle , 1989 .

[44]  L. Brunton,et al.  Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes. , 1983, The Journal of biological chemistry.

[45]  G. A. Nickols,et al.  Endothelium-independent linkage of parathyroid hormone receptors of rat vascular tissue with increased adenosine 3',5'-monophosphate and relaxation of vascular smooth muscle. , 1986, Endocrinology.

[46]  R. Paul,et al.  Effects of forskolin and cyclic nucleotides on isometric force in rat aorta. , 1986, The American journal of physiology.

[47]  J. C. Stoof,et al.  Two dopamine receptors: biochemistry, physiology and pharmacology. , 1984, Life sciences.

[48]  C. W. Scott,et al.  Phosphorylation of type II regulatory subunit of cAMP-dependent protein kinase in intact smooth muscle. , 1985, The Journal of biological chemistry.

[49]  J. Diamond,et al.  Comparison of the effects of forskolin and isoproterenol on cyclic AMP levels and tension in bovine coronary artery. , 1983, Canadian journal of physiology and pharmacology.

[50]  V. Mutt,et al.  Potent Peripheral and Splanchnic Vasodilator Peptide from Normal Gut , 1970, Nature.

[51]  J. Diamond,et al.  Effects of isoproterenol and forskolin on tension, cyclic AMP levels, and cyclic AMP dependent protein kinase activity in bovine coronary artery. , 1984, Canadian journal of physiology and pharmacology.

[52]  J. Nishimura,et al.  Direct regulation of smooth muscle contractile elements by second messengers. , 1989, Biochemical and biophysical research communications.

[53]  F. Hofmann,et al.  Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle. , 1988, The Biochemical journal.

[54]  D. McCarron,et al.  cAMP response of vascular smooth muscle cells to bovine parathyroid hormone. , 1984, The American journal of physiology.

[55]  F. Hofmann,et al.  Phosphorylation of cGMP-dependent protein kinase increases the affinity for cyclic AMP. , 1986, European journal of biochemistry.

[56]  N. Akaike,et al.  Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aortas. , 1988, The American journal of physiology.

[57]  J. Watras.  Regulation of calcium uptake in bovine aortic sarcoplasmic reticulum by cyclic AMP-dependent protein kinase. , 1988, Journal of molecular and cellular cardiology.

[58]  J. P. Huggins,et al.  Phospholamban is a good substrate for cyclic GMP-dependent protein kinase in vitro, but not in intact cardiac or smooth muscle. , 1989, The Biochemical journal.

[59]  J. Souness,et al.  Characterization of 5'-N-ethylcarboxamido[3H]adenosine binding to pig aorta smooth muscle membranes. , 1987, Biochemical pharmacology.

[60]  Bär Hp.  Cyclic nucleotides and smooth muscle. , 1974 .

[61]  M. Hirata,et al.  Effects of cAMP- and cGMP-dependent protein kinases, and calmodulin on Ca2+ uptake by highly purified sarcolemmal vesicles of vascular smooth muscle. , 1984, Biochimica et biophysica acta.

[62]  P. Silver,et al.  Differential Vasorelaxant Effects of Milrinone and Amrinone on Contractile Responses of Canine Coronary, Cerebral, and Renal Arteries , 1989, Journal of cardiovascular pharmacology.

[63]  J. Corbin,et al.  Use of synergistic pairs of site-selective cAMP analogs in intact cells. , 1988, Methods in enzymology.

[64]  A. Kurtz.  Adenosine stimulates guanylate cyclase activity in vascular smooth muscle cells. , 1987, The Journal of biological chemistry.

[65]  H. Morris,et al.  Calcitonin gene-related peptide is a potent vasodilator , 1985, Nature.

[66]  D. Hathaway,et al.  Phosphorylation of myosin light chain kinase from vascular smooth muscle by cAMP- and cGMP-dependent protein kinases. , 1985, Journal of molecular and cellular cardiology.

[67]  G. Pfitzer,et al.  Effect of calmodulin, Ca2+, and cAMP protein kinase on skinned tracheal smooth muscle. , 1984, The American journal of physiology.

[68]  G. Stiles,et al.  Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi. , 1988, Molecular pharmacology.

[69]  M. Hagiwara,et al.  Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. , 1984, Biochemical pharmacology.

[70]  P. Schoeffter,et al.  Effect of parathyroid hormone and antagonist on aortic cAMP levels. , 1987, Canadian journal of physiology and pharmacology.

[71]  P. Schoeffter,et al.  Effect of vasoactive intestinal polypeptide (VIP) on cyclic AMP level and relaxation in rat isolated aorta. , 1985, European journal of pharmacology.

[72]  G. Schultz,et al.  Control of voltage‐dependent Ca2+ channels by G protein‐coupled receptors , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[73]  A. Katz,et al.  Phosphorylation of the sarcoplasmic reticulum and sarcolemma. , 1982, Annual review of physiology.

[74]  M. Kirchberger,et al.  Effects of adenosine 3':5'-monophosphate-dependent protein kinase on sarcoplasmic reticulum isolated from cardiac and slow and fast contracting skeletal muscles. , 1976, The Journal of biological chemistry.

[75]  B. Hoffman,et al.  Role of cyclic AMP-dependent protein kinase in the diminished beta adrenergic responsiveness of vascular smooth muscle with increasing age. , 1989, The Journal of pharmacology and experimental therapeutics.

[76]  E. Carafoli,et al.  Properties of the Ca-pumping ATPase of sarcoplasmic reticulum from vascular smooth muscle. , 1984, Biochemical and biophysical research communications.

[77]  P. Casey,et al.  G proteins control diverse pathways of transmembrane signaling 1 , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[78]  V. Mutt,et al.  Polypeptide with Broad Biological Activity: Isolation from Small Intestine , 1970, Science.

[79]  R. A. Murphy,et al.  Myoplasmic [Ca2+] Determines Myosin Phosphorylation and Isometric Stress in Agonist‐Stimulated Swine Arterial Smooth Muscle , 1988, Journal of cardiovascular pharmacology.

[80]  P. J. England,et al.  The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. , 1987, The Biochemical journal.

[81]  C. Twort,et al.  Cyclic Guanosine Monophosphate‐Enhanced Sequestration of Ca2+ by Sarcoplasmic Reticulum in Vascular Smooth Muscle , 1988, Circulation research.

[82]  W. Kerrick,et al.  Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase , 1981, Nature.

[83]  J. Scott.  Cyclic nucleotide-dependent protein kinases. , 1991, Pharmacology & therapeutics.

[84]  C. van Breemen,et al.  Cyclic AMP modulation of adrenoreceptor-mediated arterial smooth muscle contraction , 1984, The Journal of general physiology.

[85]  H. Rasmussen,et al.  The effects of isoproterenol on intracellular calcium concentration. , 1988, The Journal of biological chemistry.

[86]  T. Fujita,et al.  Calcitonin gene-related peptide receptor in cultured vascular smooth muscle and endothelial cells. , 1988, Biochemical and biophysical research communications.

[87]  L. Jones,et al.  Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation. , 1989, The Journal of biological chemistry.

[88]  R. Olsson.  Local factors regulating cardiac and skeletal muscle blood flow. , 1981, Annual review of physiology.

[89]  K. Morgan,et al.  Calcium‐force coupling mechanisms during vasodilator‐induced relaxation of ferret aorta. , 1989, The Journal of physiology.

[90]  F. Fay,et al.  Beta-adrenergic effects on transmembrane 45Ca fluxes in isolated smooth muscle cells. , 1984, The American journal of physiology.

[91]  L. Adam,et al.  Phosphorylation of caldesmon in arterial smooth muscle. , 1989, The Journal of biological chemistry.

[92]  R. Bentley,et al.  Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle. , 1988, European journal of pharmacology.

[93]  L. Raeymaekers,et al.  The (Ca2+ ‐Mg2+)‐ATPases of the Plasma Membrane and of the Endoplasmic Reticulum in Smooth Muscle Cells and Their Regulation , 1988, Journal of cardiovascular pharmacology.

[94]  J. Corbin,et al.  3 Cyclic Nucleotide-Dependent Protein Kinases , 1986 .

[95]  J. Corbin.  Determination of the cAMP-dependent protein kinase activity ratio in intact tissues. , 1983, Methods in enzymology.

[96]  D. Richards,et al.  A vasodilator action of acetates , 1928, The Journal of physiology.

[97]  J. N. Wells,et al.  Phosphodiesterase inhibitors as tools in cyclic nucleotide research: A precautionary comment , 1981, Molecular and Cellular Endocrinology.

[98]  R. A. Murphy,et al.  Myosin Phosphorylation and Cyclic Adenosine 3′,5′‐Monophosphate in Relaxation of Arterial Smooth Muscle by Vasodilators , 1984, Circulation research.

[99]  J. Felbel,et al.  Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea. , 1988, The Journal of biological chemistry.

[100]  C. van Breemen,et al.  Effect of dB-c-AMP and forskolin on the 45Ca influx, net Ca uptake and tension in rabbit aortic smooth muscle. , 1987, European journal of pharmacology.

[101]  J. Rüegg,et al.  Cyclic AMP‐dependent inhibition of smooth muscle actomyosin , 1979, FEBS letters.

[102]  M. Walsh,et al.  Isolation of the native form of chicken gizzard myosin light-chain kinase. , 1984, The Biochemical journal.

[103]  C. Schmitz‐Peiffer,et al.  Use of a synthetic dodecapeptide (malantide) to measure the cyclic AMP-dependent protein kinase activity ratio in a variety of tissues. , 1990, The Biochemical journal.

[104]  T. Lincoln.  Effects of nitroprusside and 8-bromo-cyclic GMP on the contractile activity of the rat aorta. , 1983, The Journal of pharmacology and experimental therapeutics.

[105]  D. B. Evans,et al.  Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents. , 1986, Biochemical pharmacology.

[106]  G. A. Nickols,et al.  Increased cyclic AMP in cultured vascular smooth muscle cells and relaxation of aortic strips by parathyroid hormone. , 1985, European journal of pharmacology.

[107]  E. Carafoli,et al.  The Ca2+-pumping ATPase and the major substrates of the cGMP-dependent protein kinase in smooth muscle sarcolemma are distinct entities. , 1988, European journal of biochemistry.

[108]  C. Nutting,et al.  Acetate causes endothelium-independent increases in cyclic AMP in rat caudal artery. , 1988, The American journal of physiology.

[109]  J. H. Wang,et al.  Effect of phosphorylation by cyclic AMP-dependent protein kinase on the smooth muscle actomyosin Mg2+-ATPase stimulatory activity of fodrin. , 1987, Journal of Biological Chemistry.

[110]  T. Sasaguri,et al.  Nitroglycerine‐ and isoprenaline‐induced vasodilatation: assessment from the actions of cyclic nucleotides , 1985, British journal of pharmacology.

[111]  T. Martin,et al.  Calcitonin gene-related peptide stimulates cyclic AMP formation in rat aortic smooth muscle cells. , 1985, Biochemical and biophysical research communications.

[112]  B. Fredholm,et al.  Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat , 1985, Neuroscience Letters.

[113]  B. Himpens,et al.  Cell calcium and its regulation in smooth muscle , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[114]  T. Bolton,et al.  Actions of guanine nucleotides and cyclic nucleotides on calcium stores in single patch‐clamped smooth muscle cells from rabbit portal vein , 1989, British journal of pharmacology.

[115]  L. Iversen,et al.  Calcitonin gene-related peptide: novel neuropeptide. , 1986, Life sciences.

[116]  H. Karaki,et al.  Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle. , 1989, The Journal of pharmacology and experimental therapeutics.

[117]  K. King,et al.  Evidence for selective regulation of the phosphorylation of myocyte proteins by isoproterenol and prostaglandin E1. , 1982, Biochimica et biophysica acta.

[118]  B. Vallet,et al.  Cyclic adenosine 3',5'-monophosphate-dependent regulation of purified bovine aortic calcium/calmodulin-dependent myosin light chain kinase. , 1981, Biochimica et biophysica acta.

[119]  M. Cohen,et al.  In vitro vascular relaxation by new inotropic agents: relationship to phosphodiesterase inhibition and cyclic nucleotides. , 1987, The Journal of pharmacology and experimental therapeutics.

[120]  Y. Tawada,et al.  Regulation of the plasma membrane Ca2+ pump by cyclic nucleotides in cultured vascular smooth muscle cells. , 1988, The Journal of biological chemistry.

[121]  D. Bohr,et al.  Relaxation of vascular smooth muscle by isoproterenol, dibutyryl-cyclic AMP and theophylline. , 1981, The Journal of pharmacology and experimental therapeutics.

[122]  C. van Breemen,et al.  Effects of β‐adrenergic stimulation on calcium movements in rabbit aortic smooth muscle: relationship with cyclic AMP , 1982, The Journal of physiology.

[123]  P. Silver.  Biochemical aspects of inhibition of cardiovascular low (Km) cyclic adenosine monophosphate phosphodiesterase. , 1989, The American journal of cardiology.

[124]  H. Niznik.  Dopamine receptors: molecular structure and function , 1987, Molecular and Cellular Endocrinology.

[125]  F. Murad,et al.  Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[126]  K. I. Williams,et al.  Endothelial-dependent relaxant effects of vaso-active intestinal polypeptide and arachidonic acid in rat aortic strips. , 1984, Prostaglandins.

[127]  R. Butcher,et al.  Some Aspects of the Biological Role of Adenosine 3′,5′‐monophosphate (Cyclic AMP) , 1968 .

[128]  M. Blaustein,et al.  Effects of Activation on Distribution of Ca2+ in Single Arterial Smooth Muscle Cells: Determination With Fura‐2 and Digital Imaging Microscopy , 1989, Circulation research.

[129]  J. Corbin,et al.  Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. , 1988, Molecular pharmacology.

[130]  A. Farah.  Glucagon and the circulation. , 1983, Pharmacological reviews.

[131]  M. Lokhandwala,et al.  Activation of DA1 receptors by dopamine or fenoldopam increases cyclic AMP levels in the renal artery but not in the superior cervical ganglion of the rat. , 1986, The Journal of pharmacology and experimental therapeutics.

[132]  E. Sybertz,et al.  Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta. , 1989, Biochemical pharmacology.

[133]  A. Takai,et al.  Regulation of Ca2+ -dependent K+ -channel activity in tracheal myocytes by phosphorylation , 1989, Nature.

[134]  L. I. Goldberg,et al.  Dopamine receptors: applications in clinical cardiology. , 1985, Circulation.

[135]  P. Silver,et al.  beta-Adrenergic relaxation and cAMP kinase activation in coronary arterial smooth muscle. , 1982, American Journal of Physiology.

[136]  S. Korenman,et al.  Myometrial protein kinase: hormone-stimulated translocation and membrane binding of the soluble enzyme. , 1978, Archives of biochemistry and biophysics.

[137]  R. Bentley,et al.  Inhibition of the low Km cyclic AMP phosphodiesterase and activation of the cyclic AMP system in vascular smooth muscle by milrinone. , 1988, The Journal of pharmacology and experimental therapeutics.

[138]  T. Tamaki,et al.  Dopamine stimulates cAMP production in canine afferent arterioles via DA1 receptors. , 1989, The American journal of physiology.

[139]  J. Diamond,et al.  Effects of prostaglandin E1, isoproterenol and forskolin on cyclic AMP levels and tension in rabbit aortic rings. , 1986, Life sciences.

[140]  N. Ishikawa,et al.  Different types of relationship between beta-adrenergic relaxation and activation of cyclic AMP-dependent protein kinase in canine saphenous and portal veins. , 1986, European journal of pharmacology.

[141]  D. Øgreid,et al.  Activation of protein kinase isozymes by cyclic nucleotide analogs used singly or in combination. Principles for optimizing the isozyme specificity of analog combinations. , 1985, European journal of biochemistry.

[142]  M. Cantin,et al.  Presence of "Ra" and "P"-site receptors for adenosine coupled to adenylate cyclase in cultured vascular smooth muscle cells. , 1982, Biochemical and biophysical research communications.

[143]  P. Silver,et al.  Role of cyclic AMP protein kinase in decreased arterial cyclic AMP responsiveness in hypertension. , 1985, The Journal of pharmacology and experimental therapeutics.

[144]  K. Lorenz,et al.  Potentiation of the effects of sodium nitroprusside and of isoproterenol by selective phosphodiesterase inhibitors. , 1983, Molecular pharmacology.

[145]  R. Adelstein,et al.  Increased phosphorylation of myosin light chain kinase after an increase in cyclic AMP in intact smooth muscle. , 1984, Science.

[146]  B. Fredholm,et al.  Are methylxanthine effects due to antagonism of endogenous adenosine , 1979 .

[147]  P. Silver,et al.  Adenosine 3':5'-monophosphate-mediated inhibition of myosin light chain phosphorylation in bovine aortic actomyosin. , 1979, The Journal of biological chemistry.

[148]  A. Gilman,et al.  G proteins: transducers of receptor-generated signals. , 1987, Annual review of biochemistry.

[149]  J. Sellers,et al.  13 Regulation of Contractile Activity , 1987 .

[150]  M. Miyazaki,et al.  Responses of isolated dog blood vessels to glucagon. , 1986, European journal of pharmacology.