Ultrasound-navigated radiofrequency ablation of thyroid nodules with integrated electromagnetic tracking: comparison with conventional ultrasound guidance in gelatin models

PurposeA thyroid-like gelatin model was used to determine potential superiority of a new navigation system for ultrasound (US)-guided electrode insertion called EchoTrack, featuring a US probe with an integrated electromagnetic field generator, in comparison with conventional US when performing radiofrequency ablation.MethodsIn order to compare 20 navigated ablations with 20 ablations under conventional US guidance, a thyroid-like gelatin model was used. In each group, 10 in-plane and 10 out-of-plane punctures were performed. Metal seeds measuring 8.5 $$\times $$× 1.8 mm served as ablation targets. The number of redirections until final electrode placement, targeting accuracy and electrode placement time were measured.ResultsThe number of redirections could be significantly ($$p{<}0.0001$$p<0.0001) reduced from 2.7 ± 1.3 in the conventional group to 0.2 ± 0.5 in the EchoTrack group. Accuracy increased from 3.9 ± 4.7 to 2.0 ± 1.9 mm. The total placement time increased from 39 ± 20.5 to 79.2 ± 26 s.ConclusionsEchoTrack is able to reduce the redirections needed to place the electrode in comparison with conventional US and provides high placement accuracy. Our new navigation system has high potential to reduce the risk of harming critical structures and to improve guidance during ablation of difficult nodules, as treatment planning as well as the safety of out-of-plane punctures are improved.

[1]  Luca Brunese,et al.  Vascular and interventional radiology radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: literature review , 2014, La radiologia medica.

[2]  Dong Gyu Na,et al.  Thermal Ablation for Benign Thyroid Nodules: Radiofrequency and Laser , 2011, Korean journal of radiology.

[3]  Ankur Kapoor,et al.  Navigation systems for ablation. , 2010, Journal of vascular and interventional radiology : JVIR.

[4]  John B Martinie,et al.  Novel 3-D laparoscopic magnetic ultrasound image guidance for lesion targeting. , 2010, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[5]  Fen Chen,et al.  Radiofrequency ablation for treatment of benign thyroid nodules , 2016, Medicine.

[6]  A. M. Franz,et al.  Navigated targeting of liver lesions: pitfalls of electromagnetic tracking , 2012 .

[7]  Jeong Hyun Lee,et al.  Radiofrequency Ablation of Thyroid Nodules: Basic Principles and Clinical Application , 2012, International journal of endocrinology.

[8]  A M Franz,et al.  Standardized assessment of new electromagnetic field generators in an interventional radiology setting. , 2012, Medical physics.

[9]  Wolfgang Birkfellner,et al.  Electromagnetic Tracking in Medicine—A Review of Technology, Validation, and Applications , 2014, IEEE Transactions on Medical Imaging.

[10]  D. Sindram,et al.  Real-time three-dimensional guided ultrasound targeting system for microwave ablation of liver tumours: a human pilot study. , 2011, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[11]  Keno März,et al.  Interventional real-time ultrasound imaging with an integrated electromagnetic field generator , 2014, International Journal of Computer Assisted Radiology and Surgery.

[12]  Riccardo Sartoris,et al.  Percutaneous radiofrequency ablation of benign thyroid nodules assisted by a virtual needle tracking system. , 2014, Ultrasound in medicine & biology.

[13]  Wolfgang Birkfellner,et al.  Electromagnetic tracking for US-guided interventions: standardized assessment of a new compact field generator , 2012, International Journal of Computer Assisted Radiology and Surgery.

[14]  Jung Yin Huh,et al.  Benign predominantly solid thyroid nodules: prospective study of efficacy of sonographically guided radiofrequency ablation versus control condition. , 2010, AJR. American journal of roentgenology.

[15]  François Poulin,et al.  Interference during the use of an electromagnetic tracking system under OR conditions. , 2002, Journal of biomechanics.

[16]  Luigi Solbiati,et al.  Virtual navigation and fusion imaging in percutaneous ablations in the neck. , 2015, Ultrasound in medicine & biology.

[17]  I Bricault,et al.  Phantom evaluation of a navigation system for out-of-plane CT-guided puncture. , 2015, Diagnostic and interventional imaging.

[18]  Davide Orlandi,et al.  Reply regarding Virtual navigation and fusion imaging in percutaneous ablations in the neck. , 2015, Ultrasound in medicine & biology.

[19]  Jung Hwan Baek,et al.  Radiofrequency ablation of benign thyroid nodules: safety and imaging follow-up in 236 patients , 2008, European Radiology.

[20]  Keno März,et al.  MITK-US: real-time ultrasound support within MITK , 2013, International Journal of Computer Assisted Radiology and Surgery.

[21]  A. Pontecorvi,et al.  Male Fertility and Reduction in Semen Parameters: A Single Tertiary-Care Center Experience , 2012, International journal of endocrinology.

[22]  S. Nguyen,et al.  Radiofrequency ablation for treatment of benign thyroid nodules: Systematic review , 2014, The Laryngoscope.

[23]  Klaus H. Maier-Hein,et al.  The Medical Imaging Interaction Toolkit: challenges and advances , 2013, International Journal of Computer Assisted Radiology and Surgery.

[24]  G. Gazelle,et al.  Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. , 2000, AJR. American journal of roentgenology.

[25]  Dong Gyu Na,et al.  Radiofrequency Ablation of Benign Thyroid Nodules and Recurrent Thyroid Cancers: Consensus Statement and Recommendations , 2012, Korean journal of radiology.

[26]  W Luboldt,et al.  Bipolar Radiofrequency Ablation of Benign Symptomatic Thyroid Nodules: Initial Experience , 2015, Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren.

[27]  Qingling Xu,et al.  Ultrasound guided percutaneous microwave ablation of benign thyroid nodules: safety and imaging follow-up in 222 patients. , 2013, European journal of radiology.