This paper aims to understand the chronic toxicity and carcinogencity of Huahui No. 1 rice, especially the progressive or unreversal toxicity and carcinogencity. Sprague-Dawley (SD) rats were selected in the 106-week chronic toxicity test. Compared with rats of non-gene modified rice group and basic feed group, no statistical difference and toxicological changes in clinical symptoms, body weight, food utilization efficiency, hematological and biochemical index, organ weight and index, gross anatomy and histopathological observation were found in rats fed low, medium and high dosages of Huahui No. 1 rice. Tumor incidences of old rats in different groups were between 8.3% and 10% and mostly observed in subcutaneous site, and no dose-response relationship was observed. The results were in accordance with the spontaneous tumor incidence by NIH Rodent 1980 catalogur SD rats. In conclusion, no chronic toxicity and carcinogencity were found in SD rats after they were fed with Huahui No. 1 rice for 106 weeks in the experiment.