Additively Manufactured Open-Cell Porous Biomaterials Made from Six Different Space-Filling Unit Cells: The Mechanical and Morphological Properties

It is known that the mechanical properties of bone-mimicking porous biomaterials are a function of the morphological properties of the porous structure, including the configuration and size of the repeating unit cell from which they are made. However, the literature on this topic is limited, primarily because of the challenge in fabricating porous biomaterials with arbitrarily complex morphological designs. In the present work, we studied the relationship between relative density (RD) of porous Ti6Al4V EFI alloy and five compressive properties of the material, namely elastic gradient or modulus (Es20–70), first maximum stress, plateau stress, yield stress, and energy absorption. Porous structures with different RD and six different unit cell configurations (cubic (C), diamond (D), truncated cube (TC), truncated cuboctahedron (TCO), rhombic dodecahedron (RD), and rhombicuboctahedron (RCO)) were fabricated using selective laser melting. Each of the compressive properties increased with increase in RD, the relationship being of a power law type. Clear trends were seen in the influence of unit cell configuration and porosity on each of the compressive properties. For example, in terms of Es20–70, the structures may be divided into two groups: those that are stiff (comprising those made using C, TC, TCO, and RCO unit cell) and those that are compliant (comprising those made using D and RD unit cell).

[1]  C. Engh,et al.  Porous-coated hip replacement. The factors governing bone ingrowth, stress shielding, and clinical results. , 1987, The Journal of bone and joint surgery. British volume.

[2]  C. Engh,et al.  THE FACTORS GOVERNING BONE INGROWTH, STRESS SHIELDING, AND CLINICAL RESULTS , 1987 .

[3]  张哉根,et al.  Leu-M , 1991 .

[4]  Cook Sd,et al.  Biocompatibility and biofunctionality of implanted materials. , 1992 .

[5]  R. Huiskes,et al.  The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials. , 1992, Clinical orthopaedics and related research.

[6]  S. Cook,et al.  Biocompatibility and biofunctionality of implanted materials. , 1992, The Alpha omegan.

[7]  S A Goldstein,et al.  The relationship between the structural and orthogonal compressive properties of trabecular bone. , 1994, Journal of biomechanics.

[8]  W C Hayes,et al.  Mechanical behavior of damaged trabecular bone. , 1994, Journal of biomechanics.

[9]  S. Cummings,et al.  Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures , 1996, The Lancet.

[10]  I Gotman,et al.  Characteristics of metals used in implants. , 1997, Journal of endourology.

[11]  Y. Yeni,et al.  The influence of bone morphology on fracture toughness of the human femur and tibia. , 1997, Bone.

[12]  Mitsuo Niinomi,et al.  Mechanical properties of biomedical titanium alloys , 1998 .

[13]  Dennis R. Carter,et al.  Mechanobiology of Skeletal Regeneration , 1998, Clinical orthopaedics and related research.

[14]  A. Meunier,et al.  Tissue-engineered bone regeneration , 2000, Nature Biotechnology.

[15]  Dietmar W. Hutmacher,et al.  Scaffold design and fabrication technologies for engineering tissues — state of the art and future perspectives , 2001, Journal of biomaterials science. Polymer edition.

[16]  B. Wattrisse,et al.  Analysis of strain localization during tensile tests by digital image correlation , 2001 .

[17]  Jochem Nagels,et al.  Stress shielding and bone resorption in shoulder arthroplasty. , 2003, Journal of shoulder and elbow surgery.

[18]  L. Gibson,et al.  Fatigue microdamage in bovine trabecular bone. , 2003, Journal of biomechanical engineering.

[19]  John Tyson,et al.  Pull-field dynamic displacement and strain measurement using advanced 3D image correlation photogrammetry: Part 1 , 2003 .

[20]  C. Engh,et al.  Clinical Consequences of Stress Shielding After Porous-Coated Total Hip Arthroplasty , 2003, Clinical orthopaedics and related research.

[21]  Keguang Wang,et al.  Apatite formation on porous titanium by alkali and heat-treatment , 2003 .

[22]  P. Kenesei,et al.  The influence of cell-size distribution on the plastic deformation in metal foams , 2004 .

[23]  D. Arola,et al.  Applications of digital image correlation to biological tissues. , 2004, Journal of biomedical optics.

[24]  R. Huiskes,et al.  A three-dimensional digital image correlation technique for strain measurements in microstructures. , 2004, Journal of biomechanics.

[25]  Hyoun‐Ee Kim,et al.  Hydroxyapatite porous scaffold engineered with biological polymer hybrid coating for antibiotic Vancomycin release , 2005, Journal of materials science. Materials in medicine.

[26]  Franccois Hild,et al.  Digital Image Correlation: from Displacement Measurement to Identification of Elastic Properties – a Review , 2006 .

[27]  S. Hollister Porous scaffold design for tissue engineering , 2005, Nature materials.

[28]  T. Adachi,et al.  Framework for optimal design of porous scaffold microstructure by computational simulation of bone regeneration. , 2006, Biomaterials.

[29]  J. Kruth,et al.  Selective laser melting of biocompatible metals for rapid manufacturing of medical parts , 2006 .

[30]  O. Harrysson,et al.  Custom-designed orthopedic implants evaluated using finite element analysis of patient-specific computed tomography data: femoral-component case study , 2007, BMC musculoskeletal disorders.

[31]  Avi Pfeffer,et al.  INFLUENCE OF , 2014 .

[32]  G N Duda,et al.  Digital image correlation: a technique for determining local mechanical conditions within early bone callus. , 2007, Medical engineering & physics.

[33]  B Vamsi Krishna,et al.  Low stiffness porous Ti structures for load-bearing implants. , 2007, Acta biomaterialia.

[34]  Huimin Xie,et al.  Full-field strain measurement using a two-dimensional Savitzky-Golay digital differentiator in digital image correlation , 2007 .

[35]  Thomas Imwinkelried,et al.  Mechanical properties of open-pore titanium foam. , 2007, Journal of biomedical materials research. Part A.

[36]  Marco Viceconti,et al.  Subject-specific finite element models can accurately predict strain levels in long bones. , 2007, Journal of biomechanics.

[37]  Rinze Benedictus,et al.  Experimental and numerical study of machined aluminum tailor-made blanks , 2008 .

[38]  Pierre Layrolle,et al.  Rapid prototyped porous titanium coated with calcium phosphate as a scaffold for bone tissue engineering. , 2008, Biomaterials.

[39]  Ignace Verpoest,et al.  Full-field strain measurements in textile deformability studies , 2008 .

[40]  M. Bouxsein,et al.  Biomechanics of Bone and Age-Related Fractures , 2008 .

[41]  R. Singer,et al.  Cellular Ti-6Al-4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam melting. , 2008, Acta biomaterialia.

[42]  S. Hollister Scaffold Design and Manufacturing: From Concept to Clinic , 2009, Advanced materials.

[43]  C. Wen,et al.  Influence of calcium ion deposition on apatite-inducing ability of porous titanium for biomedical applications. , 2009, Acta biomaterialia.

[44]  Lewis Mullen,et al.  Selective Laser Melting: a regular unit cell approach for the manufacture of porous, titanium, bone in-growth constructs, suitable for orthopedic applications. , 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

[45]  V Mironov,et al.  Biofabrication: a 21st century manufacturing paradigm , 2009, Biofabrication.

[46]  Wenguang Zhang,et al.  Fabrication and characterization of porous Ti6Al4V parts for biomedical applications using electron beam melting process , 2009 .

[47]  A. A. Zadpoor,et al.  Elastoplastic deformation of dissimilar-alloy adhesively-bonded tailor-made blanks , 2010 .

[48]  Emeka Nkenke,et al.  In vivo performance of selective electron beam-melted Ti-6Al-4V structures. , 2010, Journal of biomedical materials research. Part A.

[49]  Lewis Mullen,et al.  Selective laser melting: a unit cell approach for the manufacture of porous, titanium, bone in-growth constructs, suitable for orthopedic applications. II. Randomized structures. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[50]  L. Murr,et al.  Next-generation biomedical implants using additive manufacturing of complex, cellular and functional mesh arrays , 2010, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[51]  Sandra J Shefelbine,et al.  BoneJ: Free and extensible bone image analysis in ImageJ. , 2010, Bone.

[52]  Shivakumar Raman,et al.  Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM). , 2010, Journal of the mechanical behavior of biomedical materials.

[53]  Joshua A. Gargac,et al.  Shear strength and toughness of trabecular bone are more sensitive to density than damage. , 2011, Journal of biomechanics.

[54]  Christopher J. Sutcliffe,et al.  Selective laser melting of aluminium components , 2011 .

[55]  Van Baela,et al.  Micro-CT-based improvement of geometrical and mechanical controllability of selective laser melted Ti6Al4V porous structures , 2011 .

[56]  J. Kruth,et al.  Micro-CT-based improvement of geometrical and mechanical controllability of selective laser melted Ti6Al4V porous structures , 2011 .

[57]  Zhimeng Guo,et al.  Preparation and properties of biomedical porous titanium alloys by gelcasting , 2011, Biomedical materials.

[58]  M Bohner,et al.  Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing. , 2011, Acta biomaterialia.

[59]  Satoru Yoneyama,et al.  DIGITAL IMAGE CORRELATION , 2011 .

[60]  P R Fernandes,et al.  Permeability analysis of scaffolds for bone tissue engineering. , 2012, Journal of biomechanics.

[61]  Martine Wevers,et al.  Surface Modification of Ti6Al4V Open Porous Structures Produced by Additive Manufacturing , 2012 .

[62]  Jan Wieding,et al.  The Effect of Structural Design on Mechanical Properties and Cellular Response of Additive Manufactured Titanium Scaffolds , 2012, Materials.

[63]  J. Ciurana,et al.  Biomedical production of implants by additive electro-chemical and physical processes , 2012 .

[64]  Yadir Torres,et al.  Processing and characterization of porous titanium for implants by using NaCl as space holder , 2012 .

[65]  R. Poprawe,et al.  Laser additive manufacturing of metallic components: materials, processes and mechanisms , 2012 .

[66]  Gladius Lewis,et al.  Properties of open-cell porous metals and alloys for orthopaedic applications , 2013, Journal of Materials Science: Materials in Medicine.

[67]  Amir A Zadpoor,et al.  Patient-specific finite element modeling of bones , 2013, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[68]  A. A. Zadpoor,et al.  Mechanical properties of open-cell metallic biomaterials manufactured using additive manufacturing , 2013 .

[69]  A. A. Zadpoor,et al.  Selective laser melting‐produced porous titanium scaffolds regenerate bone in critical size cortical bone defects , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[70]  A. A. Zadpoor,et al.  Enhanced bone regeneration of cortical segmental bone defects using porous titanium scaffolds incorporated with colloidal gelatin gels for time- and dose-controlled delivery of dual growth factors. , 2013, Tissue engineering. Part A.

[71]  Amir Abbas Zadpoor,et al.  Open forward and inverse problems in theoretical modeling of bone tissue adaptation. , 2013, Journal of the mechanical behavior of biomedical materials.

[72]  S. Hollister,et al.  Optimization of scaffold design for bone tissue engineering: A computational and experimental study. , 2014, Medical engineering & physics.

[73]  Jan Wieding,et al.  Numerical optimization of open-porous bone scaffold structures to match the elastic properties of human cortical bone. , 2014, Journal of the mechanical behavior of biomedical materials.

[74]  S. M. Ahmadi,et al.  Effects of bio-functionalizing surface treatments on the mechanical behavior of open porous titanium biomaterials. , 2014, Journal of the mechanical behavior of biomedical materials.

[75]  S. Ahmadia,et al.  Mechanical behavior of regular open-cell porous biomaterials made of diamond lattice unit cells , 2014 .

[76]  Mariana Calin,et al.  Manufacture by selective laser melting and mechanical behavior of commercially pure titanium , 2014 .

[77]  A. A. Zadpoor,et al.  Crystal structure and nanotopographical features on the surface of heat-treated and anodized porous titanium biomaterials produced using selective laser melting , 2014 .

[78]  M. Stanford,et al.  A numerical investigation into the influence of the properties of cobalt chrome cellular structures on the load transfer to the periprosthetic femur following total hip arthroplasty. , 2014, Medical engineering & physics.

[79]  L. Murr,et al.  Influence of cell shape on mechanical properties of Ti-6Al-4V meshes fabricated by electron beam melting method. , 2014, Acta biomaterialia.

[80]  S. M. Ahmadi,et al.  Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials. , 2015, Journal of the mechanical behavior of biomedical materials.

[81]  J. Kruth,et al.  Effects of build orientation and heat treatment on the microstructure and mechanical properties of selective laser melted Ti6Al4V lattice structures , 2015 .