Development of a printed impedance based electrochemical sensor on paper substrate

A novel printed impedance based electrochemical sensor has been successfully developed on a paper substrate for the detection of various bio/chemicals. This flexible analytical device was fabricated by screen printing a two electrode sensor configuration on a wax-printed chromatography paper substrate. Silver (Ag) ink was used for screen printing the working and circular electrodes. The capability of the fabricated electrochemical sensor for detecting trace concentrations of bio/chemicals such potassium chloride (KCl) and glucose (C6H12O6) was investigated. The electrical impedance spectroscopy (EIS) based response of the printed sensor revealed detection levels as low as picomolar (pM) concentrations as well as the capability of the sensor to distinguish among varying levels (pico, nano, micro and milli) of sample concentrations. The response of the developed electrochemical sensor has been analyzed and is presented in this paper.

[1]  Josiane P Lafleur,et al.  Recent advances in lab-on-a-chip for biosensing applications. , 2016, Biosensors & bioelectronics.

[2]  Aydogan Ozcan,et al.  Emerging Technologies for Next-Generation Point-of-Care Testing. , 2015, Trends in biotechnology.

[3]  Bradley J. Bazuin,et al.  A novel flexographic printed strain gauge on paper platform , 2015, 2015 IEEE SENSORS.

[4]  B. B. Narakathu,et al.  Screen Printing of Multilayered Hybrid Printed Circuit Boards on Different Substrates , 2015, IEEE Transactions on Components, Packaging and Manufacturing Technology.

[5]  Á. Ríos,et al.  Miniaturization through lab-on-a-chip: utopia or reality for routine laboratories? A review. , 2012, Analytica chimica acta.

[6]  Lauro T. Kubota,et al.  Separation and electrochemical detection of paracetamol and 4-aminophenol in a paper-based microfluidic device. , 2012, Analytica chimica acta.

[7]  Shenguang Ge,et al.  Paper-based chemiluminescence ELISA: lab-on-paper based on chitosan modified paper device and wax-screen-printing. , 2012, Biosensors & bioelectronics.

[8]  Peter B. Luppa,et al.  Point-of-care testing (POCT): Current techniques and future perspectives , 2011, TrAC Trends in Analytical Chemistry.

[9]  Shenguang Ge,et al.  A novel chemiluminescence paper microfluidic biosensor based on enzymatic reaction for uric acid determination. , 2011, Biosensors & bioelectronics.

[10]  C. Culbertson,et al.  Paper-based microfluidic devices for analysis of clinically relevant analytes present in urine and saliva , 2010, Analytical and bioanalytical chemistry.

[11]  Emanuel Carrilho,et al.  Paper microzone plates. , 2009, Analytical chemistry.

[12]  Robert Pelton,et al.  Bioactive paper provides a low-cost platform for diagnostics , 2009, TrAC Trends in Analytical Chemistry.

[13]  Axel Warsinke,et al.  Point-of-care testing of proteins , 2009, Analytical and bioanalytical chemistry.

[14]  G. Whitesides,et al.  Patterned paper as a platform for inexpensive, low-volume, portable bioassays. , 2007, Angewandte Chemie.

[15]  G. Whitesides.  The origins and the future of microfluidics , 2006, Nature.

[16]  D. Figeys,et al.  Lab-on-a-chip: a revolution in biological and medical sciences , 2000, Analytical chemistry.