Risk factors for bilateral testicular germ cell tumors. Does heredity play a role?

Twenty‐three bilateral testicular germ cell tumors (four synchronous and 19 sequential tumors) were investigated for potential risk factors. The incidence of maldescensus testis was not found to be higher than in patients with unilateral disease. The histologic findings of the first tumor did not have any effect on the incidence of the second tumor. In 21 patients (four synchronous and 17 sequential tumors), histocompatibility antigens (HLA) were determined; HLA‐B14 was increased significantly in the sequential tumor group. Tendencies toward an increase of HLA‐DR5 and HLA‐DR7 also were found. The HLA‐DR1, HLA‐DR3, and HLA‐DR4 showed a tendency toward a decreased frequency. Therefore genetic factors might be important in the development of sequential bilateral testicular cancers.

[1]  L. Weissbach,et al.  [Early detection of a contralateral second carcinoma in patients with testicular tumors caused by testicular carcinoma in situ]. , 1989, Der Urologe. Ausg. A.

[2]  H. Huland,et al.  [Carcinoma in situ of the testis: clinical significance, diagnosis and therapy]. , 1989, Der Urologe. Ausg. A.

[3]  S. Fosså,et al.  Cisplatin-based chemotherapy does not eliminate the risk of a second testicular cancer. , 1989, British journal of urology.

[4]  F. Christiansen,et al.  Antigen Society #7 Report (B8, w59, B14, w64, w65) , 1989 .

[5]  D. Forman,et al.  SIB-Pair Analyses in the Assessment of MHC Involvement in Germ Cell Tumor Pathogenesis , 1989 .

[6]  C. Bornhof,et al.  Impalpable testicular tumors diagnosed by scrotal ultrasonography. , 1988, Urology.

[7]  G. Mead,et al.  Bilateral testicular germ cell tumours: an increasing incidence and prevention by chemotherapy. , 1988, British journal of urology.

[8]  C. Hedinger,et al.  [Bilateral germ cell tumors of the testis]. , 1988, Schweizerische medizinische Wochenschrift.

[9]  K. Dieckmann,et al.  Simultaneous bilateral testicular germ cell tumors with dissimilar histology. Case report and review of the literature. , 1988, Urologia internationalis.

[10]  Y. Senturia,et al.  The epidemiology of testicular cancer. , 1987, British journal of urology.

[11]  D. Ackermann,et al.  Bilateral testicular germ cell tumors: a report of 20 cases. , 1987, The Journal of urology.

[12]  C. Kruse.  [Bilateral and familial occurrence of germ cell tumors of the testis]. , 1987, Der Urologe. Ausg. A.

[13]  W. Mayr,et al.  HLA ANTIGENS AND GERM-CELL TUMOURS , 1987, The Lancet.

[14]  K. Dieckmann,et al.  Inheritance and Testicular Cancer , 1987 .

[15]  D. Forman,et al.  GERM CELL TUMOURS OF THE TESTICLE AS A MODEL OF MHC INFLUENCE ON HUMAN MALIGNANCY , 1986, The Lancet.

[16]  W Boeckmann,et al.  Bilateral testicular germ cell tumors. Report of nine cases and review of the literature , 1986, Cancer.

[17]  J. Cuzick,et al.  THE PREVENTION OF BREAST CANCER , 1986, The Lancet.

[18]  M. Pollack,et al.  HLA and DR antigen frequencies in melanoma patients: possible relation to disease prognosis. , 2008, Tissue antigens.

[19]  M. Badzioch,et al.  Bilaterality in familial breast cancer patients , 1985, Cancer.

[20]  W. Blattner,et al.  Familial testicular cancer and urogenital developmental anomalies , 1985, Cancer.

[21]  B. Miles,et al.  Bilateral synchronous germ cell tumors. , 1985, The Journal of urology.

[22]  W D Dupont,et al.  Risk factors for breast cancer in women with proliferative breast disease. , 1985, The New England journal of medicine.

[23]  P. Terasaki,et al.  Mechanisms of HLA and Disease Associations , 1985 .

[24]  M. Badzioch,et al.  RISK OF FAMILIAL BREAST CANCER , 1984, The Lancet.

[25]  M. Hartmann,et al.  Doppelseitige Hodentumoren: Fallpräsentation und Therapiekonzept , 1984 .

[26]  A. Sandberg,et al.  Malignant teratoma of the testis with an isochromosome no. 12, i(12p), as the sole structural cytogenetic abnormality. , 1984, The Journal of urology.

[27]  B. Safai,et al.  Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma. , 2008, Tissue antigens.

[28]  M. Pike,et al.  Estrogen exposure during gestation and risk of testicular cancer. , 1983, Journal of the National Cancer Institute.

[29]  M. King,et al.  PRACTICAL GUIDE FOR ESTIMATING RISK FOR FAMILIAL BREAST CANCER , 1983, The Lancet.

[30]  W. Whitmore,et al.  Second primary germ cell tumors in patients with seminoma of the testis. , 1983, Journal of Urology.

[31]  V. Miller,et al.  Murine natural antitumor antibodies. III. Interferon treatment of a natural killer-resistant lymphoma: augmentation of natural antibody reactivity and susceptibility to in vivo natural resistance. , 1983, Journal of the National Cancer Institute.

[32]  L. Weissbach,et al.  Bilateral testicular tumor. , 1983, The Journal of urology.

[33]  N. B. Atkin,et al.  SPECIFIC CHROMOSOME CHANGE, i(12p), IN TESTICULAR TUMOURS? , 1982, The Lancet.

[34]  A. Coldman,et al.  Sports activities and risk of testicular cancer , 1982, British Journal of Cancer.

[35]  W. Whitmore,et al.  HLA antigens in patients with germ cell cancers of the testis. , 1982, Cancer research.

[36]  S. Ware,et al.  Bilateral testicular germ cell malignancy. , 1982, Urology.

[37]  W. Whitmore,et al.  Testicular cancer in cryptorchids , 1982, Cancer.

[38]  T. Wobbes,et al.  Bilateral primary germ cell tumors of testis. , 1981, Urology.

[39]  B. Kohn,et al.  HLA linkage and B14, DR1, BfS haplotype association with the genes for late onset and cryptic 21-hydroxylase deficiency. , 1981, American journal of human genetics.

[40]  W. Hendry,et al.  Bilateral germ cell tumours of the testis. , 1980, British journal of urology.

[41]  T. Jelihovsky,et al.  Father‐son testicular malignancy does genetic anticipation occur? , 1980, Cancer.

[42]  W. Ehrengut,et al.  [Testicular underlying pathology, especially mumps orchitis in patients developing testicular tumors (author's transl)]. , 1980, Der Urologe. Ausg. A.

[43]  W. Whitmore,et al.  Sequential bilateral germ cell tumors of the testis despite interval chemotherapy. , 1979, The Journal of urology.

[44]  M. Pike,et al.  Risk factors for cancer of the testis in young men , 1979, International journal of cancer.

[45]  P. Lange,et al.  HLA and testicular cancer , 1979, Nature.

[46]  J. Davis,et al.  Bilateral primary germ cell testicular tumors. Report of four cases and review of the literature , 1978, Cancer.

[47]  L. Iozzi,et al.  Familial testicular cancer in a father (bilateral seminoma‐embryonal cell carcinoma) and son (teratocarcinoma). A case report and review of the literature , 1977, Cancer.

[48]  A. Morrison.  Cryptorchidism, hernia, and cancer of the testis. , 1976, Journal of the National Cancer Institute.

[49]  H. Levin,et al.  Bilateral testicular tumors of germ cell origin. , 1975, The Journal of urology.

[50]  D. MacLaren,et al.  Letter: Pyelonephritis and coliform infections of the urinary tract. , 1975, Lancet.

[51]  P. W. Adams,et al.  VITAMIN B6, DEPRESSION, AND ORAL CONTRACEPTION , 1974 .

[52]  F. Mostofi,et al.  Testicular tumors. Epidemiologic, etiologic, and pathologic features , 1973 .

[53]  N. Skakkebæk.  POSSIBLE CARCINOMA-IN-SITU OF THE TESTIS , 1972 .

[54]  P. Koehler,et al.  Observations on the behavior of testicular tumors with comments on racial incidence. , 1962, The Journal of urology.

[55]  H. Fleischhacker.  [Blood dyscrasias in old aged people]. , 1952, Wiener klinische Wochenschrift.

[56]  Howard W. Champlin.  SIMILAR TUMORS OF TESTIS OCCURRING IN IDENTICAL TWINS , 1930 .