Tissue plasminogen activator reduces neurological damage after cerebral embolism.

Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots into the carotid circulation in rabbit embolic stroke model animals caused a significant reduction in neurological damage. In vitro studies indicate that tissue plasminogen activator produced substantial lysis of clots at concentrations comparable to those expected in vivo, suggesting that this may be the mechanism of action of this drug. Drug-induced hemorrhages were not demonstrable. Tissue plasminogen activator may be of value for the immediate treatment of embolic stroke.

[1]  M. Ter-pogossian,et al.  Clot-selective coronary thrombolysis with tissue-type plasminogen activator. , 1983, Science.

[2]  O. Matsuo,et al.  Thrombolysis by human tissue plasminogen activator and urokinase in rabbits with experimental pulmonary embolus , 1981, Nature.

[3]  R. W. Brower,et al.  RANDOMISED TRIAL OF INTRAVENOUS RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION Report from the European Cooperative Study Group for Recombinant Tissue-type Plasminogen Activator , 1985, The Lancet.

[4]  M. Hoylaerts,et al.  Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. , 1982, The Journal of biological chemistry.

[5]  M. Raichle,et al.  A Pilot Study of Urokinase Therapy in Cerebral Infarction , 1976, Stroke.

[6]  Waud Dr.  ON BIOLOGICAL ASSAYS INVOLVING QUANTAL RESPONSES , 1972 .

[7]  H. S. Mueller,et al.  The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. , 1985, The New England journal of medicine.

[8]  W. Landau,et al.  Intracranial Bleeding Associated With Urokinase Therapy for Acute Ischemic Hemispheral Stroke , 1976, Stroke.

[9]  U. Degirolami,et al.  Spectrum of neurological deficits in experimental CNS ischemia. A quantitative study. , 1982, Archives of neurology.

[10]  D. Pennica,et al.  Biological properties of human tissue-type plasminogen activator obtained by expression of recombinant DNA in mammalian cells. , 1984, The Journal of pharmacology and experimental therapeutics.

[11]  R. Busto,et al.  Energy metabolites and water content in rat brain during the early stage of development of cerebral infarction. , 1974, Brain : a journal of neurology.